1998
The synergistic activity of αvβ3 integrin and pdgf receptor increases cell migration
Woodard A, García-Cardeña G, Leong M, Madri J, Sessa W, Languino L. The synergistic activity of αvβ3 integrin and pdgf receptor increases cell migration. Journal Of Cell Science 1998, 111: 469-478. PMID: 9443896, DOI: 10.1242/jcs.111.4.469.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsAntigens, CDBecaplerminCell AdhesionCell DivisionCell MovementCells, CulturedEndothelium, VascularHumansIntegrin alphaVLamininMiceOligopeptidesPlatelet-Derived Growth FactorProto-Oncogene Proteins c-sisRatsReceptor, Platelet-Derived Growth Factor betaReceptors, Platelet-Derived Growth FactorReceptors, VitronectinVitronectinConceptsMicrovascular endothelial cellsGrowth factor receptorGrowth factorEndothelial cellsFactor receptorCell migrationSynergistic activityPlatelet-derived growth factor receptorRat microvascular endothelial cellsAlphavbeta3 integrinGrowth factor-BBNIH 3T3 cellsTissue infiltrationFactor-BBNeovessel formationDifferent antibodiesPlateletsΑvβ3 integrinReceptorsAlphavbeta3Beta1 integrinCell's abilityIntegrinsCellsNovel pathway
1996
Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1.
Lu T, Yan L, Madri J. Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 11808-11813. PMID: 8876219, PMCID: PMC38140, DOI: 10.1073/pnas.93.21.11808.Peer-Reviewed Original Research3T3 CellsAnimalsCell AdhesionCell Adhesion MoleculesCell MovementCells, CulturedEndothelium, VascularFibronectinsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesHumansMaleMiceMutagenesis, Site-DirectedPhosphorylationPhosphotyrosinePlatelet Endothelial Cell Adhesion Molecule-1Protein Tyrosine PhosphatasesProtein-Tyrosine KinasesRatsRecombinant ProteinsTransfectionTyrosineUmbilical Veins
1995
Modulation of cell spreading and migration by pp125FAK phosphorylation.
Sankar S, Mahooti-Brooks N, Hu G, Madri J. Modulation of cell spreading and migration by pp125FAK phosphorylation. American Journal Of Pathology 1995, 147: 601-8. PMID: 7677174, PMCID: PMC1870973.Peer-Reviewed Original ResearchConceptsPp125FAK tyrosine phosphorylationTyrosine phosphorylationCell migrationCell spreadingIntegrin-mediated signalingFocal adhesion kinaseKinase-negative mutantPp125FAK phosphorylationAdhesion kinaseMigration ratePhosphorylationCascade pathwayFaster migration rateControl cellsSlower migration rateType I collagenEnhanced levelsCellsI collagenFibronectinMigrationPp125FAKMutantsKinaseSignaling
1993
Characterization of distinct functional domains of transforming growth factor beta.
Burmester J, Qian S, Roberts A, Huang A, Amatayakul-Chantler S, Suardet L, Odartchenko N, Madri J, Sporn M. Characterization of distinct functional domains of transforming growth factor beta. Proceedings Of The National Academy Of Sciences Of The United States Of America 1993, 90: 8628-8632. PMID: 7690965, PMCID: PMC47411, DOI: 10.1073/pnas.90.18.8628.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAlpha-MacroglobulinsAmino Acid SequenceAnimalsCattleCHO CellsCricetinaeDose-Response Relationship, DrugEndothelium, VascularHeartHumansKineticsMiceMolecular Sequence DataReceptors, Cell SurfaceReceptors, Transforming Growth Factor betaRecombinant Fusion ProteinsRecombinant ProteinsTransforming Growth Factor betaUmbilical VeinsConceptsGrowth factor betaFactor betaHuman colorectal cancer cell linesColorectal cancer cell linesLS513 cellsCancer cell linesTGF-beta moleculesCell linesAlphaBiological potencyBetaCellsCertain cellsAmino acidsPotencyDistinct functional domainsAdditional amino acidsDifferent isoformsIsoformsDistinct isoformsFunctional domainsChimeric protein