2011
Laminar shear, but not orbital shear, has a synergistic effect with thrombin stimulation on tissue factor expression in human umbilical vein endothelial cells
Rochier A, Nixon A, Yamashita N, Abe R, Abe R, Madri JA, Sumpio BE. Laminar shear, but not orbital shear, has a synergistic effect with thrombin stimulation on tissue factor expression in human umbilical vein endothelial cells. Journal Of Vascular Surgery 2011, 54: 480-488. PMID: 21367569, DOI: 10.1016/j.jvs.2011.01.002.Peer-Reviewed Original ResearchAnalysis of VarianceBlotting, WesternCell Culture TechniquesCells, CulturedEndothelial CellsEnzyme ActivationHumansMechanotransduction, CellularMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3P38 Mitogen-Activated Protein KinasesPhosphorylationProtein Kinase InhibitorsRNA, MessengerStress, MechanicalThrombinThromboplastinTime FactorsUp-RegulationPulsatile to-fro flow induces greater and sustained expression of tissue factor RNA in HUVEC than unidirectional laminar flow
Abe R, Yamashita N, Rochier A, Abe R, Nixon A, Madri JA, Sumpio BE. Pulsatile to-fro flow induces greater and sustained expression of tissue factor RNA in HUVEC than unidirectional laminar flow. AJP Heart And Circulatory Physiology 2011, 300: h1345-h1351. PMID: 21257914, PMCID: PMC3075035, DOI: 10.1152/ajpheart.01197.2010.Peer-Reviewed Original ResearchMeSH KeywordsAtherosclerosisCells, CulturedEndothelial CellsEnzyme InhibitorsFlavonoidsHumansImidazolesMAP Kinase Kinase KinasesP38 Mitogen-Activated Protein KinasesPulsatile FlowPyridinesStress, MechanicalThrombinThromboplastin
2007
MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization
Wu Y, Zhan L, Ai Y, Hannigan M, Gaestel M, Huang CK, Madri JA. MAPKAPK2-mediated LSP1 phosphorylation and FMLP-induced neutrophil polarization. Biochemical And Biophysical Research Communications 2007, 358: 170-175. PMID: 17481585, DOI: 10.1016/j.bbrc.2007.04.104.Peer-Reviewed Original ResearchAnimalsCarrier ProteinsCell PolarityChemotaxis, LeukocyteHumansImidazolesIn Vitro TechniquesIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutMicrofilament ProteinsNeutrophil ActivationNeutrophilsN-Formylmethionine Leucyl-PhenylalanineP38 Mitogen-Activated Protein KinasesPhosphorylationProtein Serine-Threonine KinasesPseudopodiaPyridines
2005
MAPKs (ERK½, p38) and AKT Can Be Phosphorylated by Shear Stress Independently of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) in Vascular Endothelial Cells*
Sumpio BE, Yun S, Cordova AC, Haga M, Zhang J, Koh Y, Madri JA. MAPKs (ERK½, p38) and AKT Can Be Phosphorylated by Shear Stress Independently of Platelet Endothelial Cell Adhesion Molecule-1 (CD31) in Vascular Endothelial Cells*. Journal Of Biological Chemistry 2005, 280: 11185-11191. PMID: 15668248, DOI: 10.1074/jbc.m414631200.Peer-Reviewed Original ResearchAnimalsCattleCell CommunicationEndothelial CellsEnzyme ActivationHumansMechanoreceptorsMiceMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3P38 Mitogen-Activated Protein KinasesPhosphorylationPlatelet Endothelial Cell Adhesion Molecule-1Protein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktStress, MechanicalTyrosine