2008
Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades
Nath AK, Brown RM, Michaud M, Sierra-Honigmann MR, Snyder M, Madri JA. Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades. Journal Of Cell Biology 2008, 181: 367-380. PMID: 18411306, PMCID: PMC2315681, DOI: 10.1083/jcb.200708197.Peer-Reviewed Original ResearchConceptsRepertoire of factorsEndocardial cushion formationMouse embryonic heartInterleukin-6 familyEmbryonic developmentCushion formationObserved phenotypeSignal transducerAlphavbeta3 integrin receptorTranscription 3Matrix metalloprotease-2Integrin receptorsMesenchymal transitionAlphavbeta3 integrinEmbryonic heartEMTAbnormal EMTMetalloprotease-2Functional inhibitionAktLoss of leptinPathwayVivo modelReceptorsInhibition
2004
A null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels
Hallaq H, Pinter E, Enciso J, McGrath J, Zeiss C, Brueckner M, Madri J, Jacobs HC, Wilson CM, Vasavada H, Jiang X, Bogue CW. A null mutation of Hhex results in abnormal cardiac development,defective vasculogenesis and elevated Vegfa levels. Development 2004, 131: 5197-5209. PMID: 15459110, DOI: 10.1242/dev.01393.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transformationVEGFA levelsVentricular septal defectVascular endothelial growth factorDefective vasculogenesisEndothelial growth factorEndocardial cushionsInhibitor of VEGFVascular developmentTract abnormalitiesSeptal defectSFlt-1Right ventricleNormal liverVentral foregut endodermNormal cardiovascular developmentReceptor 1Abnormal cardiac developmentGrowth factorNull mutationVentral foregutAberrant developmentCompact myocardiumAV explantsE8.5-9.0
1996
Restitution at the cellular level: regulation of the migrating phenotype.
Basson M, Rashid Z, Turowski G, West A, Emenaker N, Sgambati S, Hong F, Perdikis D, Datta S, Madri J. Restitution at the cellular level: regulation of the migrating phenotype. The Yale Journal Of Biology And Medicine 1996, 69: 119-29. PMID: 9112743, PMCID: PMC2588988.Peer-Reviewed Original ResearchMeSH KeywordsActinsAlkaline PhosphataseAnimalsCell DifferentiationCell MovementCells, CulturedCollagenDipeptidyl-Peptidases and Tripeptidyl-PeptidasesEnterostomyEpidermal Growth FactorEpithelial CellsEpitheliumHumansHydrogen-Ion ConcentrationIntestinal MucosaIntestinesJejunumLamininMembrane ProteinsMicrovilliPentagastrinPeptide YYPeptidesPhosphoproteinsRatsRats, Sprague-DawleyZonula Occludens-1 ProteinConceptsIntestinal epithelial cellsCell matrix proteinsIntestinal epithelial differentiationIntestinal epithelial brush borderCaco-2 intestinal epithelial cellsCaco-2 migrationEpithelial cellsEpithelial brush borderRegulatory biologyHuman Caco-2 intestinal epithelial cellsSheet migrationCell biologyCell motilityMigratory stateMatrix proteinsDipeptidyl dipeptidaseCellular levelBrush borderCaco-2 cellsEpithelial differentiationCell linesBiologyProteinDifferentiationSpecific activity
1986
Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro.
Ingber DE, Madri JA, Jamieson JD. Basement membrane as a spatial organizer of polarized epithelia. Exogenous basement membrane reorients pancreatic epithelial tumor cells in vitro. American Journal Of Pathology 1986, 122: 129-39. PMID: 3942197, PMCID: PMC1888129.Peer-Reviewed Original ResearchConceptsDistinct membrane domainsEpithelial cell-cell interactionsCell shape changesCell-cell interactionsAcinar tumor cellsMembrane domainsTumor cellsBasement membranePolarized distributionSpatial organizersGolgi complexProtein synthesisIndividual cellsCell surfaceLipid dropletsIntracellular actinPancreatic acinar carcinomaJunctional complexesEpithelial tumor cellsCell contactCytoskeletal alterationsAmniotic basement membraneEpithelial orientationIntact basement membraneZymogen granules
1984
Bronchial Lavage Proteins as Correlates of Histopathologic Airway Changes in Healthy Smokers and Patients with Pulmonary Carcinoma1–4
Merrill W, Barwick K, Madri J, Strober W, Matthay R, Olchowski J, Naegel G, Reynolds H. Bronchial Lavage Proteins as Correlates of Histopathologic Airway Changes in Healthy Smokers and Patients with Pulmonary Carcinoma1–4. American Journal Of Respiratory And Critical Care Medicine 1984, 130: 905-9. PMID: 6208835, DOI: 10.1164/arrd.1984.130.5.905.Peer-Reviewed Original ResearchConceptsFree secretory componentSymptomatic smokersCarcinoma patientsAsymptomatic smokersLavage fluidLung diseaseCancer patientsSmoking-associated lung diseasePacks/yearHigh-risk subgroupsImportant etiologic factorNumber of smokersAirway changesAirway injuryGroups of subjectsHealthy smokersSmoking historyNormal nonsmokersLavage levelsCigarette smokingSmoking populationEtiologic factorsLavage proteinImmunohistochemical evidenceLung sections
1981
Role of basal lamina in neoplastic disorganization of tissue architecture.
Ingber D, Madri J, Jamieson J. Role of basal lamina in neoplastic disorganization of tissue architecture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1981, 78: 3901-3905. PMID: 7022458, PMCID: PMC319681, DOI: 10.1073/pnas.78.6.3901.Peer-Reviewed Original Research