2006
PECAM-1 Affects GSK-3β-Mediated β-Catenin Phosphorylation and Degradation
Biswas P, Canosa S, Schoenfeld D, Schoenfeld J, Li P, Cheas LC, Zhang J, Cordova A, Sumpio B, Madri JA. PECAM-1 Affects GSK-3β-Mediated β-Catenin Phosphorylation and Degradation. American Journal Of Pathology 2006, 169: 314-324. PMID: 16816383, PMCID: PMC1698776, DOI: 10.2353/ajpath.2006.051112.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninBlotting, WesternCapillary PermeabilityCells, CulturedEndothelial CellsFluorescent Antibody TechniqueGlycogen Synthase Kinase 3Glycogen Synthase Kinase 3 betaHistamineHistamine AgentsHumansMiceModels, BiologicalPhosphatidylinositol 3-KinasesPhosphorylationPlatelet Endothelial Cell Adhesion Molecule-1Proto-Oncogene Proteins c-aktReceptors, HistamineSignal TransductionConceptsAdherens junctionsSerine phosphorylationSrc homology 2 domainBeta-catenin expression levelsAdherens junction componentsSerine phosphorylation levelEndothelial cellsΒ-catenin phosphorylationPECAM-1Cell biological responsesCytoplasmic domainSHP-2Proteosomal degradationGSK-3betaDynamic regulatorJunction componentsPhosphorylation levelsPhosphorylationEndothelial cell adhesion molecule-1Expression levelsGSK-3βBiological responsesEndothelial barrier permeabilityMice exhibitCell adhesion molecule-1
1993
Fibronectin expression correlates with U937 cell adhesion to migrating bovine aortic endothelial cells in vitro.
Hauser I, Setter E, Bell L, Madri J. Fibronectin expression correlates with U937 cell adhesion to migrating bovine aortic endothelial cells in vitro. American Journal Of Pathology 1993, 143: 173-80. PMID: 7686342, PMCID: PMC1886955.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaCattleCell AdhesionCell MovementCells, CulturedDrug ResistanceEndothelium, VascularFibronectinsFluorescent Antibody TechniqueHumansIntegrinsLeukemia, Promyelocytic, AcuteNeomycinProto-Oncogene MasProto-Oncogene Proteins pp60(c-src)Transforming Growth Factor betaTumor Cells, CulturedConceptsCell adhesionU937 cell adhesionEndothelial cell populationSRC proto-oncogeneEndothelial cellsCell populationsExtracellular matrix componentsEndothelial cell migrationBovine aortic endothelial cellsExtracellular matrix synthesisDenudation injuryFibronectin depositionCell migrationProto-oncogeneVascular endothelial cellsU937 cellsAortic endothelial cellsAmount of fibronectinMatrix componentsMigratory responseEndothelial cell monolayersMatrix synthesisCellsCell monolayersAdhesion
1992
Differential modulation of vascular cell integrin and extracellular matrix expression in vitro by TGF‐β1 correlates with reciprocal effects on cell migration+
Basson C, Kocher O, Basson M, Asis A, Madri J. Differential modulation of vascular cell integrin and extracellular matrix expression in vitro by TGF‐β1 correlates with reciprocal effects on cell migration+. Journal Of Cellular Physiology 1992, 153: 118-128. PMID: 1522126, DOI: 10.1002/jcp.1041530116.Peer-Reviewed Original Research
1991
Beagle pup germinal matrix maturation studies.
Ment L, Stewart W, Ardito T, Madri J. Beagle pup germinal matrix maturation studies. Stroke 1991, 22: 390-395. PMID: 2003309, DOI: 10.1161/01.str.22.3.390.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsAnimals, NewbornCerebral HemorrhageCerebral VentriclesCollagenDisease Models, AnimalDogsFluorescent Antibody TechniqueLamininNerve Tissue ProteinsRisk FactorsConceptsAlpha-smooth muscle actinIntraventricular hemorrhageDay 1Muscle actinRisk periodGlial fibrillary acidic proteinGerminal matrix vasculatureNewborn beagle pupsPostnatal day 1Postnatal day 4Postnatal day 10Fibrillary acidic proteinGerminal matrix vesselsGerminal matrix tissuePreterm infantsImmunohistochemical studyPerinatal maturationPostnatal dayBeagle pupsVessel densityHemorrhageExtracellular matrix componentsDay 4Day 10Basement membrane proteins
1990
Alternative splicing of endothelial cell fibronectin mRNA in the IIICS region. Functional significance.
Kocher O, Kennedy S, Madri J. Alternative splicing of endothelial cell fibronectin mRNA in the IIICS region. Functional significance. American Journal Of Pathology 1990, 137: 1509-24. PMID: 2260635, PMCID: PMC1877716.Peer-Reviewed Original ResearchConceptsAlternative splicingIIICS regionBovine aortic endothelial cellsHuman umbilical vein endothelial cell cDNA libraryRecombinant proteinsEndothelial cell cDNA libraryCell cDNA librarySpecific gene expressionSmooth muscle cellsAortic endothelial cellsEndothelial cellsMuscle cellsB16F10 melanoma cellsMelanoma cellsVascular cell functionCell attachmentFibronectin mRNACDNA clonesCDNA libraryRGDS sequenceGene expressionDNA fragmentsSplicingSequence analysisDifferent cell populationsSpatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events.
Basson C, Knowles W, Bell L, Albelda S, Castronovo V, Liotta L, Madri J. Spatiotemporal segregation of endothelial cell integrin and nonintegrin extracellular matrix-binding proteins during adhesion events. Journal Of Cell Biology 1990, 110: 789-801. PMID: 2407741, PMCID: PMC2116027, DOI: 10.1083/jcb.110.3.789.Peer-Reviewed Original ResearchConceptsMatrix-binding proteinsBeta 1 integrinLow-affinity integrinsRGD-dependent receptorExtracellular matrix-binding proteinsIntegrin beta 1Integrin subclassesBeta 1Beta 3Endothelial cell integrinsPeptide inhibitionBAECFibrinogenBAEC migrationCell integrinsLamininPerinuclear vesiclesIntegrinsAlpha subunitMatrix proteinsAdhesive eventsFibronectinPeptidesA 48 kDa collagen-binding phosphoprotein isolated from bovine aortic endothelial cells interacts with the collagenous domain, but not the globular domain, of collagen type IV
Yannariello-Brown J, Madri J. A 48 kDa collagen-binding phosphoprotein isolated from bovine aortic endothelial cells interacts with the collagenous domain, but not the globular domain, of collagen type IV. Biochemical Journal 1990, 265: 383-392. PMID: 2154186, PMCID: PMC1136898, DOI: 10.1042/bj2650383.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaCattleCell MembraneCells, CulturedChromatography, AffinityChymotrypsinCollagenElectrophoresis, Gel, Two-DimensionalElectrophoresis, Polyacrylamide GelEndothelium, VascularFluorescent Antibody TechniqueImmune SeraMolecular WeightPeptide MappingPhosphoproteinsReceptors, Cell SurfaceReceptors, CollagenConceptsBovine aortic endothelial cellsSDS/PAGENon-equilibrium pH gel electrophoresisCollagen type IVCollagenous domainTwo-dimensional gel systemAortic endothelial cellsAdhesion assaysCell surface populationIndirect immunofluorescence experimentsGlobular NC1 domainCell surface labelingCollagen-binding proteinsChymotryptic peptide mapsEndothelial cellsGlobular domainIntracellular transportMinor isoformIndividual isoformsImmunofluorescence experimentsMolecular massGolgi regionCollagenous regionCell surfacePeptide maps
1989
Modulation of actin mRNAs in cultured vascular cells by matrix components and TGF-β1
Kocher O, Madri J. Modulation of actin mRNAs in cultured vascular cells by matrix components and TGF-β1. In Vitro Cellular & Developmental Biology 1989, 25: 424-434. PMID: 2659578, DOI: 10.1007/bf02624627.Peer-Reviewed Original ResearchConceptsTwo-dimensional cultureActin mRNAEndothelial cell populationSmooth muscle cellsIndividual extracellular matrix proteinsSmooth muscle cell differentiationCell typesRat capillary endothelial cellsMuscle cell differentiationActin mRNA expressionThree-dimensional type ISkeletal muscle cellsMatrix componentsExtracellular matrix proteinsCell populationsCytoplasmic actin mRNAsMuscle actin mRNAEndothelial cellsMuscle cellsSmooth muscle cell markersExtracellular matrix componentsCultured vascular cellsΑ-SM actinBovine aortic endothelial cellsMuscle cell markers
1988
Extracellular matrix specificity for the differentiation of capillary endothelial cells
Carley W, Milici A, Madri J. Extracellular matrix specificity for the differentiation of capillary endothelial cells. Experimental Cell Research 1988, 178: 426-434. PMID: 3049122, DOI: 10.1016/0014-4827(88)90411-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCell LineEndothelium, VascularExtracellular MatrixFluorescent Antibody TechniqueMicroscopy, ElectronConceptsExtracellular matrixCapillary endothelial cellsEndothelial cellsSpecific extracellular matrixEndothelial cell migrationVivo phenotypeDifferentiated phenotypeCell migrationCell typesCell growthCell dedifferentiationEndothelial cell growthMatrix componentsMembrane structurePhenotypeCellsExpressionCulture methodCytoplasmProteinGrowthMadinDifferentiationDedifferentiationGreater numberDistribution of a 69-kD laminin-binding protein in aortic and microvascular endothelial cells: modulation during cell attachment, spreading, and migration.
Yannariello-Brown J, Wewer U, Liotta L, Madri J. Distribution of a 69-kD laminin-binding protein in aortic and microvascular endothelial cells: modulation during cell attachment, spreading, and migration. Journal Of Cell Biology 1988, 106: 1773-1786. PMID: 2967300, PMCID: PMC2115051, DOI: 10.1083/jcb.106.5.1773.Peer-Reviewed Original ResearchPhenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix.
Madri J, Pratt B, Tucker A. Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix. Journal Of Cell Biology 1988, 106: 1375-1384. PMID: 3283153, PMCID: PMC2115017, DOI: 10.1083/jcb.106.4.1375.Peer-Reviewed Original Research
1987
Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels.
Davis B, Pratt B, Madri J. Retinol and extracellular collagen matrices modulate hepatic Ito cell collagen phenotype and cellular retinol binding protein levels. Journal Of Biological Chemistry 1987, 262: 10280-10286. PMID: 3301832, DOI: 10.1016/s0021-9258(18)61109-3.Peer-Reviewed Original Research
1986
A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution*
INGBER D, MADRI J, FOLKMAN J. A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution*. Endocrinology 1986, 119: 1768-1775. PMID: 2428602, DOI: 10.1210/endo-119-4-1768.Peer-Reviewed Original ResearchMeSH KeywordsAllantoisAnimalsBasement MembraneCapillariesChick EmbryoChorionFibronectinsFluorescent Antibody TechniqueHeparinHydroxycorticosteroidsLamininNeovascularization, PathologicMechanisms of cytoskeletal regulation: Modulation of aortic endothelial cell protein band 4.1 by the extracellular matrix
Leto T, Pratt B, Madri J. Mechanisms of cytoskeletal regulation: Modulation of aortic endothelial cell protein band 4.1 by the extracellular matrix. Journal Of Cellular Physiology 1986, 127: 423-431. PMID: 3519624, DOI: 10.1002/jcp.1041270311.Peer-Reviewed Original ResearchConceptsActin filamentsExtracellular matrixProtein 4.1Band 4.1Contact inhibitionCytoplasmic actin filamentsTransduction of informationCell-cell contactCortical membrane proteinsErythroid proteinCytoskeletal regulationSpecific cleavage productsMembrane proteinsSkeletal proteinsCysteine residuesCell cytoskeletonEndothelial cellsFilamentous distributionECM proteinsEndothelial cell cytoskeletonFibronectin substrateReorganization eventsCell nucleiComplex pathwaysImmunoblot analysisRepopulation of a human alveolar matrix by adult rat type II pneumocytes in vitro A novel system for type II pneumocyte culture
Lwebuga-Mukasa J, Ingbar D, Madri J. Repopulation of a human alveolar matrix by adult rat type II pneumocytes in vitro A novel system for type II pneumocyte culture. Experimental Cell Research 1986, 162: 423-435. PMID: 3510880, DOI: 10.1016/0014-4827(86)90347-2.Peer-Reviewed Original Research
1985
Immunolocalization of type IV collagen and laminin in nonbasement membrane structures of murine corneal stroma. A light and electron microscopic study.
Pratt B, Madri J. Immunolocalization of type IV collagen and laminin in nonbasement membrane structures of murine corneal stroma. A light and electron microscopic study. Laboratory Investigation 1985, 52: 650-6. PMID: 3892156.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCollagenCorneaCorneal StromaFluorescent Antibody TechniqueHistocytochemistryMiceMicroscopy, ElectronMyofibrilsRatsConceptsElectron microscopic immunolocalizationMicrofibril bundlesInterstitial collagen types IType IV collagenPossible functionsExtracellular matrixImmunofluorescent localizationMembrane structureIV collagenCollagen type IType IType V collagenOxytalan microfibrilsImmunolocalizationCellular sourceMicrofibrilsLaminin
1984
Scar cancers of the lung: Origin and significance
Madri J, Carter D. Scar cancers of the lung: Origin and significance. Human Pathology 1984, 15: 625-631. PMID: 6378757, DOI: 10.1016/s0046-8177(84)80286-5.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCicatrixCollagenFluorescent Antibody TechniqueHumansLung NeoplasmsNecrosisPulmonary FibrosisConceptsPulmonary neoplasiaFibrotic processHost responseNontumorous areasScar cancerPulmonary tumorsColonic neoplasmsLung parenchymaFibrotic responseType III collagenCollagen antibodiesNeoplasmsCurrent conceptsType IIIDesmoplasiaLungNeoplasiaScarringTumorsScarCancerType ICollagen typesDifferent collagen typesCollagen
1982
Aortic endothelial cell migration. I. Matrix requirements and composition.
Madri J, Stenn K. Aortic endothelial cell migration. I. Matrix requirements and composition. American Journal Of Pathology 1982, 106: 180-6. PMID: 7039330, PMCID: PMC1916178.Peer-Reviewed Original Research
1981
Role of basal lamina in neoplastic disorganization of tissue architecture.
Ingber D, Madri J, Jamieson J. Role of basal lamina in neoplastic disorganization of tissue architecture. Proceedings Of The National Academy Of Sciences Of The United States Of America 1981, 78: 3901-3905. PMID: 7022458, PMCID: PMC319681, DOI: 10.1073/pnas.78.6.3901.Peer-Reviewed Original Research
1980
The collagenous components of the subendothelium. Correlation of structure and function.
Madri J, Dreyer B, Pitlick F, Furthmayr H. The collagenous components of the subendothelium. Correlation of structure and function. Laboratory Investigation 1980, 43: 303-15. PMID: 7003251.Peer-Reviewed Original ResearchConceptsCell surfaceEndothelial cell surfaceEndothelial cellsSpecific immunoprecipitation techniquesBiosynthetic incorporationImmunofluorescence microscopyImmunoelectron microscopyImmunoprecipitation techniquesAB2 collagenCellsCollagenous componentsAggregation occursCorrelation of structureCollagen typesImportant roleMonolayer of endotheliumCollagenPlatelet adhesionPlatelet aggregationImportant determinantNonthrombogenic surfaceVascular wallTreesType IVAdhesion