Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future
Buhimschi CS, Bhandari V, Han YW, Dulay AT, Baumbusch MA, Madri JA, Buhimschi IA. Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future. Current Opinion In Infectious Diseases 2009, 22: 235-243. PMID: 19395960, PMCID: PMC2763282, DOI: 10.1097/qco.0b013e32832a5963.Peer-Reviewed Original ResearchConceptsNeonatal sepsisEarly-onset neonatal sepsisInsulin-like growth factor-binding protein-1Growth factor-binding protein-1Proteomic biomarkersAdvanced glycation end productsAmniotic fluid biomarkersAmniotic fluid inflammationFetal immune responsePoor neurodevelopmental outcomesIntra-amniotic infectionRisk of sepsisGlycation end productsHistological chorioamnionitisPreterm birthInflammatory statusNeurodevelopmental outcomesNeuroprotection strategiesInflammatory stateNeurological injuryFluid biomarkersInflammatory processImmune responseAmniotic fluidDefensin 2Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects
Nath AK, Krauthammer M, Li P, Davidov E, Butler LC, Copel J, Katajamaa M, Oresic M, Buhimschi I, Buhimschi C, Snyder M, Madri JA. Proteomic-Based Detection of a Protein Cluster Dysregulated during Cardiovascular Development Identifies Biomarkers of Congenital Heart Defects. PLOS ONE 2009, 4: e4221. PMID: 19156209, PMCID: PMC2626248, DOI: 10.1371/journal.pone.0004221.Peer-Reviewed Original ResearchConceptsCardiovascular developmentMass spectrometry-based proteomicsSpectrometry-based proteomicsNormal cardiovascular developmentAdhesion/migrationHuman CHDsProteomic datasetsHeart developmentProtein clustersMurine embryosProtein pathwayMolecular pathwaysFunctional roleProteinEmbryonic survivalYolk sacProtein levelsIdentifies biomarkersCardiovascular defectsWestern blottingPathwayNovel avenuesEmbryosComplete understandingProtein biomarkers