2017
Increased Oxidative Stress and Hypoxia Inducible Factor-1 Expression during Arteriovenous Fistula Maturation
Sadaghianloo N, Yamamoto K, Bai H, Tsuneki M, Protack CD, Hall MR, Declemy S, Hassen-Khodja R, Madri J, Dardik A. Increased Oxidative Stress and Hypoxia Inducible Factor-1 Expression during Arteriovenous Fistula Maturation. Annals Of Vascular Surgery 2017, 41: 225-234. PMID: 28163173, PMCID: PMC5411319, DOI: 10.1016/j.avsg.2016.09.014.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaArteriovenous Shunt, SurgicalGene Expression RegulationHeme Oxygenase-1Hydrogen PeroxideHyperplasiaHypoxia-Inducible Factor 1, alpha SubunitMaleMembrane ProteinsMice, Inbred C57BLNADPH Oxidase 2NeointimaOxidative StressReactive Oxygen SpeciesSignal TransductionTime FactorsTyrosineVascular Endothelial Growth Factor AVascular PatencyVena Cava, InferiorConceptsHeme oxygenase-1Arteriovenous fistulaAVF maturationNOX-2HIF-1αOxidative stressHypoxia-inducible factor 1 (HIF-1) expressionSham-operated micePoor clinical resultsHIF-1α immunoreactivityInferior vena cavaArteriovenous fistula maturationVascular endothelial growth factorHypoxia-inducible factor-1 (HIF-1) pathwayFactor-1 expressionEndothelial growth factorHIF-1 pathwayHuman AVF maturationQuantitative polymerase chain reactionOxidative stress increasesAortocaval fistulaFistula maturationVena cavaClinical resultsPolymerase chain reaction
2007
PECAM-1: a multifaceted regulator of megakaryocytopoiesis
Wu Y, Welte T, Michaud M, Madri JA. PECAM-1: a multifaceted regulator of megakaryocytopoiesis. Blood 2007, 110: 851-859. PMID: 17412889, PMCID: PMC1924763, DOI: 10.1182/blood-2006-05-022087.Peer-Reviewed Original ResearchJuvenile Hyaline Fibromatosis and Infantile Systemic Hyalinosis Overlap Associated With a Novel Mutation in Capillary Morphogenesis Protein-2 Gene
Antaya RJ, Cajaiba MM, Madri J, Lopez MA, Ramirez MC, Martignetti JA, Reyes-Múgica M. Juvenile Hyaline Fibromatosis and Infantile Systemic Hyalinosis Overlap Associated With a Novel Mutation in Capillary Morphogenesis Protein-2 Gene. American Journal Of Dermatopathology 2007, 29: 99-103. PMID: 17284973, DOI: 10.1097/01.dad.0000245636.39098.e5.Peer-Reviewed Original ResearchMeSH KeywordsAllelesConnective Tissue DiseasesDNAFemaleFibromaGerm-Line MutationHumansHyalinInfantMembrane ProteinsReceptors, PeptideSkinSkin DiseasesConceptsJuvenile hyaline fibromatosisInfantile systemic hyalinosisHyaline fibromatosisCapillary morphogenesis gene 2Painful skin lesionsImpairment of movementNovel mutationsVisceral involvementClinical pictureClinicopathologic findingsRare conditionSkin lesionsSystemic hyalinosisSubcutaneous tissueProtein 2 geneSevere disabilityGermline mutationsFibromatosisDiseaseAllelic diseasesGene 2Unclear natureMutationsHyalinosisLesions
2003
The evolving roles of cell surface proteases in health and disease: Implications for developmental, adaptive, inflammatory, and neoplastic processes
Madri JA. The evolving roles of cell surface proteases in health and disease: Implications for developmental, adaptive, inflammatory, and neoplastic processes. Current Topics In Developmental Biology 2003, 54: 391-410. PMID: 12696757, DOI: 10.1016/s0070-2153(03)54016-9.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAnimalsCell MembraneEndopeptidasesHumansInflammationMembrane ProteinsNeoplasmsSignal TransductionConceptsCell surface proteolysisCell surface proteaseSurface proteolysisSurface proteaseDiversity of enzymesExtracellular matrix remodelingMaintenance of homeostasisBiological functionsMatrix remodelingAdaptive responseNormal homeostasisProteolytic responseCell proliferationProteolysisProtease activityEnzyme systemGeneral importanceHomeostasisProteaseCell attractionVascular systemDegenerative diseasesImportant processNeoplastic processComplement system
2002
Disrupted synaptic development in the hypoxic newborn brain
Curristin SM, Cao A, Stewart WB, Zhang H, Madri JA, Morrow JS, Ment LR. Disrupted synaptic development in the hypoxic newborn brain. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 15729-15734. PMID: 12438650, PMCID: PMC137784, DOI: 10.1073/pnas.232568799.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisAtmosphere Exposure ChambersBrain Damage, ChronicCell DifferentiationCytoskeletonDisease Models, AnimalDNA, ComplementaryEndothelial Growth FactorsGene Expression ProfilingHypoxiaHypoxia, BrainHypoxia-Inducible Factor 1, alpha SubunitIntercellular Signaling Peptides and ProteinsLymphokinesMembrane ProteinsMiceMice, Inbred C57BLMicrotubulesNerve Tissue ProteinsOligodendrogliaOligonucleotide Array Sequence AnalysisStress, PhysiologicalSynapsesSynaptic TransmissionTranscription FactorsTranscription, GeneticVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsPostnatal hypoxiaCerebral maturationGlial maturationNewborn brainSynaptic maturationPresynaptic functionPostsynaptic functionSublethal hypoxiaSynaptic developmentHealth crisisHypoxiaCognitive disabilitiesBrainMaturation programMaturationDysynchronyNeuropathologyInfantsNeurotransmissionCohortProtein assaysMiceHypoxic
1999
New paradigms of signaling in the vasculature: ephrins and metalloproteases
Ilan N, Madri J. New paradigms of signaling in the vasculature: ephrins and metalloproteases. Current Opinion In Biotechnology 1999, 10: 536-540. PMID: 10600686, DOI: 10.1016/s0958-1669(99)00026-9.Peer-Reviewed Original ResearchMeSH KeywordsBlood VesselsHydrolysisMembrane ProteinsMetalloendopeptidasesNeovascularization, PhysiologicSignal Transduction
1996
Restitution at the cellular level: regulation of the migrating phenotype.
Basson M, Rashid Z, Turowski G, West A, Emenaker N, Sgambati S, Hong F, Perdikis D, Datta S, Madri J. Restitution at the cellular level: regulation of the migrating phenotype. The Yale Journal Of Biology And Medicine 1996, 69: 119-29. PMID: 9112743, PMCID: PMC2588988.Peer-Reviewed Original ResearchMeSH KeywordsActinsAlkaline PhosphataseAnimalsCell DifferentiationCell MovementCells, CulturedCollagenDipeptidyl-Peptidases and Tripeptidyl-PeptidasesEnterostomyEpidermal Growth FactorEpithelial CellsEpitheliumHumansHydrogen-Ion ConcentrationIntestinal MucosaIntestinesJejunumLamininMembrane ProteinsMicrovilliPentagastrinPeptide YYPeptidesPhosphoproteinsRatsRats, Sprague-DawleyZonula Occludens-1 ProteinConceptsIntestinal epithelial cellsCell matrix proteinsIntestinal epithelial differentiationIntestinal epithelial brush borderCaco-2 intestinal epithelial cellsCaco-2 migrationEpithelial cellsEpithelial brush borderRegulatory biologyHuman Caco-2 intestinal epithelial cellsSheet migrationCell biologyCell motilityMigratory stateMatrix proteinsDipeptidyl dipeptidaseCellular levelBrush borderCaco-2 cellsEpithelial differentiationCell linesBiologyProteinDifferentiationSpecific activity
1990
Interactions of Vascular Cells with Transforming Growth Factors‐βa
MADRI J, KOCHER O, MERWIN J, BELL L, TUCKER A, BASSON C. Interactions of Vascular Cells with Transforming Growth Factors‐βa. Annals Of The New York Academy Of Sciences 1990, 593: 243-258. PMID: 1695825, DOI: 10.1111/j.1749-6632.1990.tb16116.x.Peer-Reviewed Original Research
1986
Mechanisms of cytoskeletal regulation: Modulation of aortic endothelial cell protein band 4.1 by the extracellular matrix
Leto T, Pratt B, Madri J. Mechanisms of cytoskeletal regulation: Modulation of aortic endothelial cell protein band 4.1 by the extracellular matrix. Journal Of Cellular Physiology 1986, 127: 423-431. PMID: 3519624, DOI: 10.1002/jcp.1041270311.Peer-Reviewed Original ResearchConceptsActin filamentsExtracellular matrixProtein 4.1Band 4.1Contact inhibitionCytoplasmic actin filamentsTransduction of informationCell-cell contactCortical membrane proteinsErythroid proteinCytoskeletal regulationSpecific cleavage productsMembrane proteinsSkeletal proteinsCysteine residuesCell cytoskeletonEndothelial cellsFilamentous distributionECM proteinsEndothelial cell cytoskeletonFibronectin substrateReorganization eventsCell nucleiComplex pathwaysImmunoblot analysis
1981
Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix
Engel J, Odermatt E, Engel A, Madri J, Furthmayr H, Rohde H, Timpl R. Shapes, domain organizations and flexibility of laminin and fibronectin, two multifunctional proteins of the extracellular matrix. Journal Of Molecular Biology 1981, 150: 97-120. PMID: 6795355, DOI: 10.1016/0022-2836(81)90326-0.Peer-Reviewed Original Research