Characterization of RAGE, HMGB1, and S100β in Inflammation-Induced Preterm Birth and Fetal Tissue Injury
Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G, Bhandari V, Ehrenkranz RA, Weiner CP, Madri JA, Buhimschi IA. Characterization of RAGE, HMGB1, and S100β in Inflammation-Induced Preterm Birth and Fetal Tissue Injury. American Journal Of Pathology 2009, 175: 958-975. PMID: 19679874, PMCID: PMC2731116, DOI: 10.2353/ajpath.2009.090156.Peer-Reviewed Original ResearchConceptsDamage-associated molecular pattern moleculesMolecular pattern moleculesPreterm birthTissue injuryPattern moleculesInflammation-induced preterm birthBiology of RAGEExpression of RAGERole of RAGERobust inflammatory responseRelease of HMGB1Fetal inflammationFetal injuryFetal circulationFetal damageImmune activationInterleukin-6Inflammatory responseAdvanced glycationAnimal modelsCellular injuryHuman fetusesTissue damageS100 proteinInjuryUsing proteomics in perinatal and neonatal sepsis: hopes and challenges for the future
Buhimschi CS, Bhandari V, Han YW, Dulay AT, Baumbusch MA, Madri JA, Buhimschi IA. Using proteomics in perinatal and neonatal sepsis: hopes and challenges for the future. Current Opinion In Infectious Diseases 2009, 22: 235-243. PMID: 19395960, PMCID: PMC2763282, DOI: 10.1097/qco.0b013e32832a5963.Peer-Reviewed Original ResearchConceptsNeonatal sepsisEarly-onset neonatal sepsisInsulin-like growth factor-binding protein-1Growth factor-binding protein-1Proteomic biomarkersAdvanced glycation end productsAmniotic fluid biomarkersAmniotic fluid inflammationFetal immune responsePoor neurodevelopmental outcomesIntra-amniotic infectionRisk of sepsisGlycation end productsHistological chorioamnionitisPreterm birthInflammatory statusNeurodevelopmental outcomesNeuroprotection strategiesInflammatory stateNeurological injuryFluid biomarkersInflammatory processImmune responseAmniotic fluidDefensin 2