2012
Low-Grade Gliomas When and How to Treat
Omay SB, Piepmeier JM, Knisely JP. Low-Grade Gliomas When and How to Treat. Hematology/Oncology Clinics Of North America 2012, 26: 797-809. PMID: 22794284, DOI: 10.1016/j.hoc.2012.05.001.Peer-Reviewed Original ResearchConceptsSurgical resectionLow-grade gliomasPatient-specific variablesSame imaging techniqueRadiotherapeutic managementUncommon tumorClinical trialsOperative techniqueHistopathologic characterizationGrade gliomasOptimal managementAdditional studiesGliomasResectionAdequate samplesImaging techniquesPatientsPrognosisManagementTumorsTrials
2009
Current concepts in the evaluation and management of WHO grade II gliomas
Piepmeier JM. Current concepts in the evaluation and management of WHO grade II gliomas. Journal Of Neuro-Oncology 2009, 92: 253-259. PMID: 19357953, DOI: 10.1007/s11060-009-9870-z.Peer-Reviewed Original ResearchConceptsHigh-grade lesionsGrade II gliomasRandomized clinical trialsLow-grade lesionsAdditional genetic mutationsAdjuvant treatmentAppropriate therapyClinical trialsClinical reportsFatal diseaseLesionsUnique lesionGenetic mutationsCurrent conceptsContinued investigationGliomasRecent findingsSelection criteriaPatientsTherapyTumorsDiseaseTrials
1998
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. Journal Of Neurosurgery 1998, 89: 699-706. PMID: 9817404, DOI: 10.3171/jns.1998.89.5.0699.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryHours of injuryCord injuryFunctional recoveryRandomized double-blind clinical trialMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-CareMethylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Neurosurgical FOCUS 1998, 5: e1. DOI: 10.3171/foc.1998.5.3.1.Peer-Reviewed Original ResearchAcute spinal cord injuryHours of injurySpinal cord injuryFunctional recoveryCord injuryMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMethods PatientsMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-Care
1990
The effect of calmodulin inhibitors with bleomycin on the treatment of patients with high grade gliomas.
Hait W, Byrne T, Piepmeier J, Durivage H, Choudhury S, Davis C, Gates J. The effect of calmodulin inhibitors with bleomycin on the treatment of patients with high grade gliomas. Cancer Research 1990, 50: 6636-40. PMID: 1698540.Peer-Reviewed Original ResearchConceptsCentral nervous systemClinical trialsNormal brainNervous systemPhase II clinical trialPhase I clinical trialFatal pulmonary toxicityObjective tumor responseTreatment of patientsHigh-grade gliomasComplete responseCombination therapyPulmonary toxicityTumor responseFatal malignancyMalignant gliomasPreclinical modelsPharmacological characteristicsGrade gliomasGlioblastoma multiformePatientsGliomasRat cerebrumCalmodulin inhibitorsBleomycin
1986
The Spinal Cord Injury Problem—A Review
COLLINS W, PIEPMEIER J, OGLE E. The Spinal Cord Injury Problem—A Review. Journal Of Neurotrauma 1986, 3: 317-331. PMID: 3555851, DOI: 10.1089/cns.1986.3.317.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryClinical trialsSingle randomized clinical trialCentral nervous system injuryRandomized clinical trialsNervous system injuryNeurological outcomeNeurological deficitsSteroid treatmentSecondary injuryNeurological functionSystem injuryTreatment regimensClinical seriesSpinal cordLow doseHigh doseTherapeutic goalsTherapeutic effectivenessInjuryInjury problemSocietal costsSignificant differencesBiochemical changes