2023
Imaging metabolism of deuterated glucose in patients with primary brain tumors
Corbin Z, Liu Y, Fulbright R, Thaw-Poon S, Baehring J, Blondin N, Kim P, Omuro A, Chiang V, Moliterno J, Omay S, Piepmeier J, Rothman D, de Graaf R, De Feyter H. Imaging metabolism of deuterated glucose in patients with primary brain tumors. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/0142.Peer-Reviewed Original Research
2012
Low-Grade Gliomas When and How to Treat
Omay SB, Piepmeier JM, Knisely JP. Low-Grade Gliomas When and How to Treat. Hematology/Oncology Clinics Of North America 2012, 26: 797-809. PMID: 22794284, DOI: 10.1016/j.hoc.2012.05.001.Peer-Reviewed Original ResearchConceptsSurgical resectionLow-grade gliomasPatient-specific variablesSame imaging techniqueRadiotherapeutic managementUncommon tumorClinical trialsOperative techniqueHistopathologic characterizationGrade gliomasOptimal managementAdditional studiesGliomasResectionAdequate samplesImaging techniquesPatientsPrognosisManagementTumorsTrials
2009
Primary, non-exophytic, optic nerve germ cell tumors
DiLuna ML, Two AM, Levy GH, Patel T, Huttner AJ, Duncan CC, Piepmeier JM. Primary, non-exophytic, optic nerve germ cell tumors. Journal Of Neuro-Oncology 2009, 95: 437-443. PMID: 19554263, DOI: 10.1007/s11060-009-9941-1.Peer-Reviewed Original ResearchConceptsGerm cell tumorsOptic chiasmatic gliomasMalignant mixed germ cell tumorMixed germ cell tumorOptic chiasmCell tumorsOptic chiasm tumorAdrenal axis dysfunctionSub-frontal approachChiasm gliomaChiasmatic gliomasAxis dysfunctionBiopsy confirmationProgressive symptomsVisual lossCase seriesFirst patientTreatment regimensPterional craniotomyDiabetes insipidusTissue diagnosisTissue biopsiesTumorsPatientsChiasmCurrent concepts in the evaluation and management of WHO grade II gliomas
Piepmeier JM. Current concepts in the evaluation and management of WHO grade II gliomas. Journal Of Neuro-Oncology 2009, 92: 253-259. PMID: 19357953, DOI: 10.1007/s11060-009-9870-z.Peer-Reviewed Original ResearchConceptsHigh-grade lesionsGrade II gliomasRandomized clinical trialsLow-grade lesionsAdditional genetic mutationsAdjuvant treatmentAppropriate therapyClinical trialsClinical reportsFatal diseaseLesionsUnique lesionGenetic mutationsCurrent conceptsContinued investigationGliomasRecent findingsSelection criteriaPatientsTherapyTumorsDiseaseTrials
2006
The Interactions of Polarographic Measurements of Oxygen Tension and Histological Grade in Human Glioma
Lally BE, Rockwell S, Fischer DB, Collingridge DR, Piepmeier JM, Knisely JP. The Interactions of Polarographic Measurements of Oxygen Tension and Histological Grade in Human Glioma. The Cancer Journal 2006, 12: 461-466. PMID: 17207315, DOI: 10.1097/00130404-200611000-00005.Peer-Reviewed Original ResearchConceptsHistological gradeHigh-grade gliomasLow-grade gliomasTumor oxygen tensionUnivariate analysisOxygen tensionGrade gliomasSignificant independent prognostic indicatorExtent of surgeryType of anesthesiaIndependent prognostic indicatorEppendorf pO2 histographTissue oxygen tensionNormal brain tissueImplications of hypoxiaOverall survivalProspective trialPatient ageEntire cohortPrognostic indicatorPatient genderPoor survivalMedian pO2PatientsPO2 histograph
1999
Phase I Evaluation of Preirradiation Chemotherapy with Carmustine and Cisplatin and Accelerated Radiation Therapy in Patients with High-grade Gliomas
Piepmeier J. Phase I Evaluation of Preirradiation Chemotherapy with Carmustine and Cisplatin and Accelerated Radiation Therapy in Patients with High-grade Gliomas. Neurosurgery 1999, 44: 73-73. DOI: 10.1097/00006123-199901000-00039.Peer-Reviewed Original Research
1998
Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial.
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. Journal Of Neurosurgery 1998, 89: 699-706. PMID: 9817404, DOI: 10.3171/jns.1998.89.5.0699.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryHours of injuryCord injuryFunctional recoveryRandomized double-blind clinical trialMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-CareMethylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up
Bracken M, Shepard M, Holford T, Leo-Summers L, Aldrich E, Fazl M, Fehlings M, Herr D, Hitchon P, Marshall L, Nockels R, Pascale V, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Neurosurgical FOCUS 1998, 5: e1. DOI: 10.3171/foc.1998.5.3.1.Peer-Reviewed Original ResearchAcute spinal cord injuryHours of injurySpinal cord injuryFunctional recoveryCord injuryMortality rate 1 yearDouble-blind clinical trialMotor function recoveryMP regimenMethods PatientsMotor recoveryMP therapyTherapy 3Neurological gradeMorbidity rateSphincter controlFunction recoveryMethylprednisolone regimenClinical trialsMedical factorsTreatment groupsPatientsRegimenInjurySelf-Care
1997
Low-grade gliomas of chronic epilepsy: A distinct clinical and pathological entity
Bartolomei J, Christopher S, Vives K, Spencer D, Piepmeier J. Low-grade gliomas of chronic epilepsy: A distinct clinical and pathological entity. Journal Of Neuro-Oncology 1997, 34: 79-84. PMID: 9210054, DOI: 10.1023/a:1005711321343.Peer-Reviewed Original ResearchConceptsLow-grade gliomasChronic epilepsyDysembryoplastic neuroepithelial tumorPathological entityLong-term patient outcomesSpecific pathological entityManagement of patientsResults of patientsDistinct pathological entityLack of mortalityPreoperative seizuresNeuroepithelial tumorsTumor recurrencePatient outcomesAnaplastic transformationEpilepsySame tumorGliomasCortical locationTumorsPatientsRecurrenceSeizuresPopulationMortality
1996
Tumors and approaches to the lateral ventricles
Piepmeier J. Tumors and approaches to the lateral ventricles. Journal Of Neuro-Oncology 1996, 30: 267-274. PMID: 8943102, DOI: 10.1007/bf00177278.Peer-Reviewed Original ResearchConceptsLateral ventricular tumorsVentricular tumorsLateral ventricleSuccessful surgical therapyUnique surgical challengeVariety of tumorsSurgical therapyNonspecific symptomsSurgical challengeFurther injuryMedical attentionNeurological problemsCognitive impairmentCognitive functionTumorsOptimal outcomesLesionsVentricleHydrocephalusPatientsTherapyInjurySymptomsA phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain
Halperin E, Herndon J, Schold S, Brown M, Vick N, Cairncross J, Macdonald D, Gaspar L, Fischer B, Dropcho E, Rosenfeld S, Morowitz R, Piepmeier J, Hait W, Byrne T, Salter M, Imperato J, Khandekar J, Paleologos N, Burger P, Bentel G, Friedman A. A phase III randomized prospective trial of external beam radiotherapy, mitomycin C, carmustine, and 6-mercaptopurine for the treatment of adults with anaplastic glioma of the brain. International Journal Of Radiation Oncology • Biology • Physics 1996, 34: 793-802. PMID: 8598355, DOI: 10.1016/0360-3016(95)02025-x.Peer-Reviewed Original ResearchConceptsExternal beam radiotherapyKarnofsky performance statusMedian survivalSurvival benefitERT groupAnaplastic gliomasBeam radiotherapyMitomycin CVs. 11.4 monthsProportion of patientsSignificant survival benefitPossible survival benefitTreatment of adultsYears of ageBCNU groupPerformance statusProspective trialHistologic diagnosisMalignant gliomasMito groupStereotactic biopsyPatientsGreater riskFourth weekThird day
1992
Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study.
Bracken M, Shepard M, Collins W, Holford T, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H, Young W. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. Journal Of Neurosurgery 1992, 76: 23-31. PMID: 1727165, DOI: 10.3171/jns.1992.76.1.0023.Peer-Reviewed Original ResearchConceptsHours of injuryAcute spinal cord injurySpinal cord injuryNaloxone treatmentCord injuryMotor functionSecond National Acute Spinal Cord Injury StudyNational Acute Spinal Cord Injury StudyAcute Spinal Cord Injury StudySpinal Cord Injury StudyAcute spinal cord traumaPreservation of motorTrial of methylprednisoloneSpinal cord traumaTotal sensoryPlacebo groupCord traumaNeurological functionStudy doseEmergency roomMethylprednisoloneInjury studiesMortality ratePatientsSensory function
1991
Surgical Management of Lateral Ventricular Tumors
Piepmeier J, Sass K. Surgical Management of Lateral Ventricular Tumors. Developments In Oncology 1991, 333-335. DOI: 10.1007/978-94-011-3152-0_59.Peer-Reviewed Original ResearchLateral ventricular tumorsVentricular tumorsRisk of seizuresTranscallosal surgeryConsecutive patientsNeurologic examinationNeurologic functionSurgical treatmentSurgical managementRange of pathologiesTranscallosal approachTumor exposureCorpus callosumExcessive retractionOperative procedureTumorsCognitive functionSevere memory problemsPatientsSurgeryRelative deficitMemory problemsRelative liabilityDeficitsPerformance IQ
1990
The effect of calmodulin inhibitors with bleomycin on the treatment of patients with high grade gliomas.
Hait W, Byrne T, Piepmeier J, Durivage H, Choudhury S, Davis C, Gates J. The effect of calmodulin inhibitors with bleomycin on the treatment of patients with high grade gliomas. Cancer Research 1990, 50: 6636-40. PMID: 1698540.Peer-Reviewed Original ResearchConceptsCentral nervous systemClinical trialsNormal brainNervous systemPhase II clinical trialPhase I clinical trialFatal pulmonary toxicityObjective tumor responseTreatment of patientsHigh-grade gliomasComplete responseCombination therapyPulmonary toxicityTumor responseFatal malignancyMalignant gliomasPreclinical modelsPharmacological characteristicsGrade gliomasGlioblastoma multiformePatientsGliomasRat cerebrumCalmodulin inhibitorsBleomycinA Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury
Bracken M, Shepard M, Collins W, Holford T, Young W, Baskin D, Eisenberg H, Flamm E, Leo-Summers L, Maroon J, Marshall L, Perot P, Piepmeier J, Sonntag V, Wagner F, Wilberger J, Winn H. A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury. New England Journal Of Medicine 1990, 322: 1405-1411. PMID: 2278545, DOI: 10.1056/nejm199005173222001.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryNeurologic recoverySafety of methylprednisoloneSystematic neurological examinationPlacebo-controlled trialHours of injuryMajor morbidityNeurologic outcomeControlled TrialsNeurological examinationIncomplete lesionsMotor functionMethylprednisoloneNaloxonePatientsBody weightSensory functionInjuryPlaceboInfusionBolusEffective remainsTreatmentDose
1988
Malignant Glioma of the Optic Chiasm Eight Years After Radiotherapy for Prolactinoma
Hufnagel T, Kim J, Lesser R, Miller J, Abrahams J, Piepmeier J, Manuelidis E. Malignant Glioma of the Optic Chiasm Eight Years After Radiotherapy for Prolactinoma. JAMA Ophthalmology 1988, 106: 1701-1705. PMID: 3196211, DOI: 10.1001/archopht.1988.01060140873031.Peer-Reviewed Original ResearchLate neurological changes following traumatic spinal cord injury.
Piepmeier J, Jenkins N. Late neurological changes following traumatic spinal cord injury. Journal Of Neurosurgery 1988, 69: 399-402. PMID: 3404238, DOI: 10.3171/jns.1988.69.3.0399.Peer-Reviewed Original ResearchConceptsSpinal cord injuryTraumatic spinal cord injuryCord injuryNeurological functionPatient's spinal cord injuryFunctional neurological statusFrankel scaleNeurological statusNeurological examinationSpinal traumaYears postinjuryNeurological changesPatient statusInjuryMajority of improvementsPatientsExaminationSignificant changesStatusYearsPostinjuryHospitalTraumaPrimary leptomeningeal sarcomatosis. Case report.
Thibodeau L, Ariza A, Piepmeier J. Primary leptomeningeal sarcomatosis. Case report. Journal Of Neurosurgery 1988, 68: 802-5. PMID: 3357038, DOI: 10.3171/jns.1988.68.5.0802.Peer-Reviewed Original ResearchConceptsCerebrospinal fluid examinationMultiple cranial nervesPrimary leptomeningeal sarcomatosisMeningeal diseaseFluid examinationSurgical explorationClinical evidenceOpen biopsyCase reportPathological diagnosisProgressive deficitsCranial nervesSpinal rootsInvasive methodBiopsyDiffuse processDiseaseDiagnosisReportSarcomatosisLeptomeningesPatientsNerve
1987
Observations on the current treatment of low-grade astrocytic tumors of the cerebral hemispheres.
Piepmeier J. Observations on the current treatment of low-grade astrocytic tumors of the cerebral hemispheres. Journal Of Neurosurgery 1987, 67: 177-81. PMID: 3598677, DOI: 10.3171/jns.1987.67.2.0177.Peer-Reviewed Original ResearchConceptsLow-grade astrocytic tumorsComputerized tomographyCerebral hemispheresAstrocytic tumorsPreoperative neurological examinationUse of CTCurrent treatment methodsTreatment methodsPatient ageNeurological examinationTotal resectionTumor locationCurrent treatmentIntravenous administrationCT scanEarly diagnosisSurvival timeTumor enhancementContrast materialOptimal managementOnly factorPatientsLesionsOutcome statisticsTumors