2005
Novel Tumor-Specific Isoforms of BEHAB/Brevican Identified in Human Malignant Gliomas
Viapiano MS, Bi WL, Piepmeier J, Hockfield S, Matthews RT. Novel Tumor-Specific Isoforms of BEHAB/Brevican Identified in Human Malignant Gliomas. Cancer Research 2005, 65: 6726-6733. PMID: 16061654, DOI: 10.1158/0008-5472.can-05-0585.Peer-Reviewed Original ResearchConceptsBEHAB/brevicanHigh-grade gliomasMalignant gliomasBrain tumorsNew potential therapeutic targetsPrimary brain tumorsNormal adult brainDeadly brain tumorCentral nervous systemPotential therapeutic targetLow-grade gliomasHuman malignant gliomasNew therapeutic strategiesPathologic courseSimilar histologyBenign gliomasAdult brainTherapeutic strategiesDiffuse invasionTherapeutic targetGlioma progressionNervous systemInvasive abilityBrain tissueGliomas
1996
BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines.
Jaworski D, Kelly G, Piepmeier J, Hockfield S. BEHAB (brain enriched hyaluronan binding) is expressed in surgical samples of glioma and in intracranial grafts of invasive glioma cell lines. Cancer Research 1996, 56: 2293-8. PMID: 8625302.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsBiomarkers, TumorBrain NeoplasmsBrevicanCarrier ProteinsChild, PreschoolChondroitin Sulfate ProteoglycansFemaleGliomaHumansHyaluronic AcidIn Situ HybridizationLectins, C-TypeMaleMiddle AgedNeoplasm InvasivenessNeoplasm ProteinsNeoplasm TransplantationNerve Tissue ProteinsRatsRats, Inbred LewRats, Sprague-DawleyTumor Cells, CulturedConceptsGlioma cell linesSurgical samplesIntracranial graftsCell linesAdult human cortexInvasive glioma cell linesBrain metastasesNonglial tumorsNoninvasive cell linesMalignant gliomasExtracellular brainNormal brainTumor invasionHyaluronan-binding proteinHuman cortexGliomasTumorsInvasive behaviorStandard cell culture conditionsGraftBrainBEHABCell culture conditionsSelective markerMetastasis