1996
In vitro inhibition of cell proliferation, viability, and invasiveness in U87MG human glioblastoma cells by estramustine phosphate.
Yoshida D, Piepmeier J, Teramoto A. In vitro inhibition of cell proliferation, viability, and invasiveness in U87MG human glioblastoma cells by estramustine phosphate. Neurosurgery 1996, 39: 360-6. PMID: 8832674, DOI: 10.1097/00006123-199608000-00025.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, AlkylatingBrain NeoplasmsCell DivisionCell LineCell MovementCell SurvivalDose-Response Relationship, DrugEstramustineGlioblastomaHumansNeoplasm InvasivenessTumor Cells, CulturedConceptsEstramustine phosphateMumol/LGlioblastoma cell linesCell proliferationRelative survival ratesTreatment of glioblastomaCell linesTime-dependent depressionAnti-invasive abilityDevelopment of agentsHuman glioblastoma cell linesU87MG human glioblastoma cellsHuman glioblastoma cellsSurvival rateTumor proliferationDrug concentrationsMonotetrazolium assayAntiproliferative capacityCell invasivenessGlioblastoma cellsNon-DNA targetsBasement membraneInvasion indexInvasive potentialSelective antiproliferative activity
1994
Selective antimitotic effects of estramustine correlate with its antimicrotubule properties on glioblastoma and astrocytes.
Yoshida D, Cornell-Bell A, Piepmeier J. Selective antimitotic effects of estramustine correlate with its antimicrotubule properties on glioblastoma and astrocytes. Neurosurgery 1994, 34: 863-7; discussion 867-8. PMID: 8052384, DOI: 10.1227/00006123-199405000-00012.Peer-Reviewed Original ResearchConceptsAntimitotic effectHuman glioblastoma cellsGlioma cellsGlioblastoma cellsEstramustine binding proteinModest antiproliferative effectsConcentration-dependent cytotoxic effectConcentration-dependent inhibitionEstramustine treatmentImmunohistochemical analysisAstrocyte viabilityEstramustineAstrocyte culturesAntiproliferative effectsMonoclonal antibodiesAstrocytesHuman glioblastomaTumor culturesCytotoxic effectsDimethylthiazol-2Diphenyltetrazolium bromideAntimicrotubule activityDeoxyribonucleic acid synthesis
1993
Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells.
Piepmeier J, Keefe D, Weinstein M, Yoshida D, Zielinski J, Lin T, Chen Z, Naftolin F. Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells. Neurosurgery 1993, 32: 422-30; discussion 430-1. PMID: 8384327, DOI: 10.1227/00006123-199303000-00014.Peer-Reviewed Original Research