2023
Identifying treatment heterogeneity in atrial fibrillation using a novel causal machine learning method
Ngufor C, Yao X, Inselman J, Ross J, Dhruva S, Graham D, Lee J, Siontis K, Desai N, Polley E, Shah N, Noseworthy P, MN; New Haven C. Identifying treatment heterogeneity in atrial fibrillation using a novel causal machine learning method. American Heart Journal 2023, 260: 124-140. PMID: 36893934, PMCID: PMC10615250, DOI: 10.1016/j.ahj.2023.02.015.Peer-Reviewed Original ResearchConceptsOral anticoagulantsAtrial fibrillationPatient subgroupsComposite outcomeIschemic strokeEffect of OACsLifelong oral anticoagulationNonvitamin K antagonistNew oral anticoagulantsNonvalvular atrial fibrillationPrimary composite outcomeGlomerular filtration rateFuture prospective studiesOptumLabs Data WarehousePopulation-level effectivenessOAC useOral anticoagulationVASc scoreCause mortalityK antagonistsPrimary endpointWarfarin usersRenal functionAF patientsEntire cohort
2022
A Different Case of Penumbra—Reply
Kadakia KT, Ross JS, Krumholz HM. A Different Case of Penumbra—Reply. JAMA Internal Medicine 2022, 182: 570-571. PMID: 35285863, DOI: 10.1001/jamainternmed.2022.0105.Commentaries, Editorials and Letters
2019
Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials
Brennan JM, Wruck L, Pencina MJ, Clare RM, Lopes RD, Alexander JH, O'Brien S, Krucoff M, Rao SV, Wang TY, Curtis LH, Newby LK, Granger CB, Patel M, Mahaffey K, Ross JS, Normand SL, Eloff BC, Caños DA, Lokhnygina YV, Roe MT, Califf RM, Marinac-Dabic D, Peterson ED. Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials. American Heart Journal 2019, 218: 110-122. PMID: 31726314, DOI: 10.1016/j.ahj.2019.09.002.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomedical ResearchCardiovascular DiseasesCoronary Artery BypassData AccuracyDatabases, FactualFee-for-Service PlansFemaleFollow-Up StudiesHumansInpatientsInsurance Claim ReviewKaplan-Meier EstimateMaleMedical Record LinkageMedicareMulticenter Studies as TopicMyocardial InfarctionMyocardial RevascularizationRandomized Controlled Trials as TopicRetrospective StudiesStrokeUnited StatesConceptsCardiovascular clinical trialsMyocardial infarctionEvent ratesClinical researchRandomized cardiovascular clinical trialsClinical trialsTrial participantsClinical events committee’s adjudicationsOverall cardiovascular event ratesTreatment effectsAnnual event rateCardiovascular event ratesMedicare inpatient claimsClinical trial dataOutcomes of interestSite-reported eventsCase concordanceCardiovascular outcomesRetrospective studyHigher event ratesInpatient claimsClinical dataMedicare claimsClaims dataDuke Database
2015
Physician and other healthcare personnel responses to hospital stroke quality of care performance feedback: a qualitative study
Ross JS, Williams L, Damush TM, Matthias M. Physician and other healthcare personnel responses to hospital stroke quality of care performance feedback: a qualitative study. BMJ Quality & Safety 2015, 25: 441. PMID: 26253122, DOI: 10.1136/bmjqs-2015-004197.Peer-Reviewed Original ResearchConceptsStroke qualityVHA hospitalsCare measuresHealthcare personnelVeterans Health Administration hospitalsStroke care processesPublic reportingQuality improvement effortsAdministration HospitalCare processesHospitalPhysiciansRelevant physiciansHospital administratorsYears of experienceHospital performanceCliniciansNursesQualitative studyInterview transcriptsPersonnel responsesImprovement effortsIdentified areasFeedback initiativeQualitative interviews
2014
National trends in stroke after acute myocardial infarction among Medicare patients in the United States: 1999 to 2010
Wang Y, Lichtman JH, Dharmarajan K, Masoudi FA, Ross JS, Dodson JA, Chen J, Spertus JA, Chaudhry SI, Nallamothu BK, Krumholz HM. National trends in stroke after acute myocardial infarction among Medicare patients in the United States: 1999 to 2010. American Heart Journal 2014, 169: 78-85.e4. PMID: 25497251, PMCID: PMC4824179, DOI: 10.1016/j.ahj.2014.06.011.Peer-Reviewed Original Research
2012
The Use and Misuse of Thrombolytic Therapy Within the Veterans Health Administration
Keyhani S, Arling G, Williams LS, Ross JS, Ordin DL, Myers J, Tyndall G, Vogel B, Bravata DM. The Use and Misuse of Thrombolytic Therapy Within the Veterans Health Administration. Medical Care 2012, 50: 66-73. PMID: 22182924, DOI: 10.1097/mlr.0b013e3182294092.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAged, 80 and overBrain IschemiaFemaleFibrinolytic AgentsHealth Services MisuseHealth Status IndicatorsHumansMaleMiddle AgedRetrospective StudiesSocioeconomic FactorsStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorUnited StatesUnited States Department of Veterans AffairsConceptsVHA medical centersTissue plasminogen activatorVeterans Health AdministrationAcute ischemic strokeEligible patientsStroke patientsIschemic strokeSymptom onsetThrombolytic therapyHealth AdministrationStroke symptom onsetAcute stroke patientsIschemic stroke patientsEligible stroke patientsMedical record reviewLow annual volumeThrombolysis deliveryRecord reviewWrong doseVHA systemClinical conditionsMedical CenterEligible veteransEligibility criteriaPatients
2011
Estimating and Reporting on the Quality of Inpatient Stroke Care by Veterans Health Administration Medical Centers
Arling G, Reeves M, Ross J, Williams LS, Keyhani S, Chumbler N, Phipps MS, Roumie C, Myers LJ, Salanitro AH, Ordin DL, Myers J, Bravata DM. Estimating and Reporting on the Quality of Inpatient Stroke Care by Veterans Health Administration Medical Centers. Circulation Cardiovascular Quality And Outcomes 2011, 5: 44-51. PMID: 22147888, PMCID: PMC3261327, DOI: 10.1161/circoutcomes.111.961474.Peer-Reviewed Original ResearchConceptsVeterans Health Administration medical centersStroke care qualityEligible patientsMedical CenterInpatient stroke care qualityDeep vein thrombosis prophylaxisEvidence-based quality indicatorsCare qualityInpatient stroke carePressure ulcer risk assessmentUlcer risk assessmentStudy patientsThrombosis prophylaxisEarly ambulationIschemic strokeLipid managementRetrospective cohortDysphagia screeningStroke careMedian numberPatientsFiscal year 2007Interfacility variationQuality indicatorsQI ratesCorrelation of Inpatient and Outpatient Measures of Stroke Care Quality Within Veterans Health Administration Hospitals
Ross JS, Arling G, Ofner S, Roumie CL, Keyhani S, Williams LS, Ordin DL, Bravata DM. Correlation of Inpatient and Outpatient Measures of Stroke Care Quality Within Veterans Health Administration Hospitals. Stroke 2011, 42: 2269-2275. PMID: 21719771, PMCID: PMC3144276, DOI: 10.1161/strokeaha.110.611913.Peer-Reviewed Original ResearchConceptsDefect-free careInternational normalized ratioDischarge care qualityStroke care qualityLow-density lipoproteinBlood pressureNormalized ratioCare qualityVeterans Health Administration medical centersLow-density lipoprotein goalsVeterans Health Administration hospitalsComposite rateChart-abstracted dataHemoglobin target levelsTobacco cessation counselingAcute ischemic strokeVeterans Health AdministrationComposite measureIntegrated health systemQuality of careAmbulatory care qualityHemoglobin goalLipoprotein goalsPostdischarge ratesCessation counselingPrevalence of Inadequate Blood Pressure Control Among Veterans After Acute Ischemic Stroke Hospitalization
Roumie CL, Ofner S, Ross JS, Arling G, Williams LS, Ordin DL, Bravata DM. Prevalence of Inadequate Blood Pressure Control Among Veterans After Acute Ischemic Stroke Hospitalization. Circulation Cardiovascular Quality And Outcomes 2011, 4: 399-407. PMID: 21693725, PMCID: PMC3140571, DOI: 10.1161/circoutcomes.110.959809.Peer-Reviewed Original ResearchConceptsBP controlBlood pressureIschemic strokeStroke patientsLower oddsAcute ischemic stroke hospitalizationsInadequate blood pressure controlHistory of hypertensionPercent of patientsBlood pressure controlElevated blood pressureSystolic blood pressureIschemic stroke hospitalizationsYears of ageHypertension careHypertension historyDischarge dispositionStroke eventsIndex eventStroke hospitalizationsBlack raceBP valuesCardiovascular diseaseNational guidelinesPatients
2009
Use of Stroke Secondary Prevention Services
Ross JS, Halm EA, Bravata DM. Use of Stroke Secondary Prevention Services. Stroke 2009, 40: 1811-1819. PMID: 19265044, PMCID: PMC2768116, DOI: 10.1161/strokeaha.108.539619.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAspirinCross-Sectional StudiesData Interpretation, StatisticalDelivery of Health CareEthnicityFemaleGeographyHealth BehaviorHealth Care SurveysHealth StatusHealthcare DisparitiesHumansLife StyleMaleMiddle AgedPlatelet Aggregation InhibitorsRisk FactorsSex FactorsSocioeconomic FactorsStrokeUnited StatesYoung AdultConceptsSecondary prevention servicesOutpatient rehabilitationPrevention servicesRegular exerciseService useHealth care access characteristicsBehavior Risk Factor Surveillance SystemRisk Factor Surveillance SystemSmoking cessation counselingHistory of strokeMultivariable logistic regressionStroke Belt statesNon-Hispanic blacksOverall service useLow useState residenceSex-based differencesRace-based differencesPneumococcal vaccinationAntihypertensive medicationsCessation counselingStroke outcomeSelf-reported useAge 80Stroke Belt