2007
Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor
Yuzawa S, Opatowsky Y, Zhang Z, Mandiyan V, Lax I, Schlessinger J. Structural Basis for Activation of the Receptor Tyrosine Kinase KIT by Stem Cell Factor. Cell 2007, 130: 323-334. PMID: 17662946, DOI: 10.1016/j.cell.2007.05.055.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBinding SitesCrystallography, X-RayDimerizationDiseaseEnzyme ActivationHumansLigandsModels, MolecularMolecular Sequence DataMutationProtein BindingProtein Structure, SecondaryProtein Structure, TertiaryProto-Oncogene Proteins c-kitStem Cell FactorStructure-Activity RelationshipConceptsStem cell factorReceptor dimerizationLigand-induced receptor dimerizationCell factorMultiple cellular responsesTyrosine kinase activationReceptor tyrosine kinase KITKIT dimerizationTyrosine kinase KITDomain D4Structural basisCritical residuesKinase activationSCF stimulationCellular responsesConformational changesOncogenic mutationsCultured cellsAmino acidsPoint mutationsKIT activationEntire ectodomainKinase KITKey hallmarksSole role
1992
Differential Effects of Carboxy-Terminal Sequence Deletions on Platelet-Derived Growth Factor Receptor Signaling Activities and Interactions with Cellular Substrates
Seedorf K, Millauer B, Kostka G, Schlessinger J, Ullrich A. Differential Effects of Carboxy-Terminal Sequence Deletions on Platelet-Derived Growth Factor Receptor Signaling Activities and Interactions with Cellular Substrates. Molecular And Cellular Biology 1992, 12: 4347-4356. DOI: 10.1128/mcb.12.10.4347-4356.1992.Peer-Reviewed Original ResearchNIH 3T3 cellsRas GTPase-activating proteinCarboxy-terminal amino acidsSignaling pathwayGTPase-activating proteinSignaling activityAmino acidsWild-type levelsPDGF-RSubstrates in vitroC-terminal truncationEGF-RReceptor signaling activityMitogenic activityPhosphotidylinositol 3-kinaseWild-type receptorBiological signaling activitiesSequence deletionsSubstrate phosphorylationCellular polypeptidesCellular proteinsCytoplasmic domainIntracellular sequencesSignaling potentialExtracellular domain