2014
The docking protein FRS2α is a critical regulator of VEGF receptors signaling
Chen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M. The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 5514-5519. PMID: 24706887, PMCID: PMC3992672, DOI: 10.1073/pnas.1404545111.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCell MovementDNA PrimersEndothelial CellsGene Expression ProfilingGenetic VectorsHEK293 CellsHuman Umbilical Vein Endothelial CellsHumansImmunoblottingImmunohistochemistryImmunoprecipitationLaser-Doppler FlowmetryLentivirusMembrane ProteinsMiceReal-Time Polymerase Chain ReactionReceptors, Vascular Endothelial Growth FactorSignal TransductionX-Ray MicrotomographyConceptsLymphatic endothelial cell migrationFibroblast growth factor receptor substrate 2Growth factor receptor substrate 2Cognate receptor tyrosine kinasesFactor receptor substrate 2Receptor kinase signalingVascular endothelial growth factorPostnatal vascular developmentReceptor tyrosine kinasesEndothelial cell migrationKinase signalingEndothelial-specific deletionAdult angiogenesisVEGF receptorsTyrosine kinaseCritical regulatorVascular developmentFRS2αSubstrate 2Cell migrationDependent activationCritical roleUnidentified componentsGrowth factorEndothelial growth factor
1991
Epidermal Growth Factor (EGF) Stimulates Association and Kinase Activity of Raf-1 with the EGF Receptor
App H, Hazan R, Zilberstein A, Ullrich A, Schlessinger J, Rapp U. Epidermal Growth Factor (EGF) Stimulates Association and Kinase Activity of Raf-1 with the EGF Receptor. Molecular And Cellular Biology 1991, 11: 913-919. DOI: 10.1128/mcb.11.2.913-919.1991.Peer-Reviewed Original ResearchRaf-1Raf-1 kinaseEpidermal growth factorPhosphorylation of c-Raf-1Kinase activityKinase activity of Raf-1Activation of Raf-1Phosphorylation of Raf-1Sodium dodecyl sulfate gelsRaf-1 activationImmunocomplex kinase assayEGF signal transductionC-Raf-1Dodecyl sulfate gelsTyrosine kinase activityTyrosine phosphorylationSerine residuesHistone H1Kinase assaySignal transductionDownstream effectorsStimulated associationEGF receptorKinaseGrowth factor
1988
Chicken Epidermal Growth Factor (EGF) Receptor: cDNA Cloning, Expression in Mouse Cells, and Differential Binding of EGF and Transforming Growth Factor Alpha
Lax I, Johnson A, Howk R, Sap J, Bellot F, Winkler M, Ullrich A, Vennstrom B, Schlessinger J, Givol D. Chicken Epidermal Growth Factor (EGF) Receptor: cDNA Cloning, Expression in Mouse Cells, and Differential Binding of EGF and Transforming Growth Factor Alpha. Molecular And Cellular Biology 1988, 8: 1970-1978. DOI: 10.1128/mcb.8.5.1970-1978.1988.Peer-Reviewed Original ResearchHuman EGF receptorChicken EGF receptorEpidermal growth factorNIH 3T3 cellsEGF receptorCDNA clonesMammalian epidermal growth factorDifferential bindingTGF-aEndogenous EGF receptorsBinding of epidermal growth factorGrowth factorMurine epidermal growth factorCoding sequenceApparent molecular weightTransforming growth factor-alphaCDNA constructsAvian EGF receptorMouse cellsPrimary structureGrowth factor-alphaCDNAChicken receptorMammalian receptorsFactor-alpha