1992
Differential Effects of Carboxy-Terminal Sequence Deletions on Platelet-Derived Growth Factor Receptor Signaling Activities and Interactions with Cellular Substrates
Seedorf K, Millauer B, Kostka G, Schlessinger J, Ullrich A. Differential Effects of Carboxy-Terminal Sequence Deletions on Platelet-Derived Growth Factor Receptor Signaling Activities and Interactions with Cellular Substrates. Molecular And Cellular Biology 1992, 12: 4347-4356. DOI: 10.1128/mcb.12.10.4347-4356.1992.Peer-Reviewed Original ResearchNIH 3T3 cellsRas GTPase-activating proteinCarboxy-terminal amino acidsSignaling pathwayGTPase-activating proteinSignaling activityAmino acidsWild-type levelsPDGF-RSubstrates in vitroC-terminal truncationEGF-RReceptor signaling activityMitogenic activityPhosphotidylinositol 3-kinaseWild-type receptorBiological signaling activitiesSequence deletionsSubstrate phosphorylationCellular polypeptidesCellular proteinsCytoplasmic domainIntracellular sequencesSignaling potentialExtracellular domain
1988
Release of a Phorbol Ester-Induced Mitogenic Block by Mutation at Thr-654 of the Epidermal Growth Factor Receptor
Livneh E, Dull T, Berent E, Prywes R, Ullrich A, Schlessinger J. Release of a Phorbol Ester-Induced Mitogenic Block by Mutation at Thr-654 of the Epidermal Growth Factor Receptor. Molecular And Cellular Biology 1988, 8: 2302-2308. DOI: 10.1128/mcb.8.6.2302-2308.1988.Peer-Reviewed Original ResearchThr-654Epidermal growth factorEpidermal growth factor receptorNIH 3T3 cellsTyr-654Ligand binding affinityIn vitro site-directed mutagenesisWild-type human EGF receptorMutant receptorsEGF receptor mutantKinase C phosphorylationPhosphorylation of serineSurface of NIH 3T3 cellsSite-directed mutagenesisHuman EGF receptorPhosphorylation of sitesStimulated receptor phosphorylationEGF-induced mitogenesisNegative control mechanismMouse NIH 3T3 fibroblastsWild-type receptorNIH 3T3 fibroblastsThreonine residuesC phosphorylationStimulate DNA synthesisChicken Epidermal Growth Factor (EGF) Receptor: cDNA Cloning, Expression in Mouse Cells, and Differential Binding of EGF and Transforming Growth Factor Alpha
Lax I, Johnson A, Howk R, Sap J, Bellot F, Winkler M, Ullrich A, Vennstrom B, Schlessinger J, Givol D. Chicken Epidermal Growth Factor (EGF) Receptor: cDNA Cloning, Expression in Mouse Cells, and Differential Binding of EGF and Transforming Growth Factor Alpha. Molecular And Cellular Biology 1988, 8: 1970-1978. DOI: 10.1128/mcb.8.5.1970-1978.1988.Peer-Reviewed Original ResearchHuman EGF receptorChicken EGF receptorEpidermal growth factorNIH 3T3 cellsEGF receptorCDNA clonesMammalian epidermal growth factorDifferential bindingTGF-aEndogenous EGF receptorsBinding of epidermal growth factorGrowth factorMurine epidermal growth factorCoding sequenceApparent molecular weightTransforming growth factor-alphaCDNA constructsAvian EGF receptorMouse cellsPrimary structureGrowth factor-alphaCDNAChicken receptorMammalian receptorsFactor-alpha