2007
Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation
Lew ED, Bae JH, Rohmann E, Wollnik B, Schlessinger J. Structural basis for reduced FGFR2 activity in LADD syndrome: Implications for FGFR autoinhibition and activation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 19802-19807. PMID: 18056630, PMCID: PMC2148379, DOI: 10.1073/pnas.0709905104.Peer-Reviewed Original ResearchMeSH KeywordsAbnormalities, MultipleAdenosine TriphosphateAlanineCrystallography, X-RayHumansModels, MolecularMutationPhosphorylationProtein BindingProtein Structure, TertiaryReceptor, Fibroblast Growth Factor, Type 1Receptor, Fibroblast Growth Factor, Type 2Structural Homology, ProteinSubstrate SpecificitySyndromeConceptsFibroblast growth factor receptor 2Tyrosine kinase activityKinase activityStatic crystallographic snapshotsKinase hinge regionSevere skeletal disorderTyrosine kinase domainAutophosphorylation kineticsFGFR2 kinaseFGFR1 kinaseKinase domainKey residuesStructural basisMutation altersFGFR2 activityConformational dynamicsCrystallographic snapshotsStringent modeCatalytic pocketFGF receptorsFunction mutationsKinaseMultiple gainsMissense mutationsAutoinhibition
1991
Epidermal Growth Factor (EGF) Stimulates Association and Kinase Activity of Raf-1 with the EGF Receptor
App H, Hazan R, Zilberstein A, Ullrich A, Schlessinger J, Rapp U. Epidermal Growth Factor (EGF) Stimulates Association and Kinase Activity of Raf-1 with the EGF Receptor. Molecular And Cellular Biology 1991, 11: 913-919. DOI: 10.1128/mcb.11.2.913-919.1991.Peer-Reviewed Original ResearchRaf-1Raf-1 kinaseEpidermal growth factorPhosphorylation of c-Raf-1Kinase activityKinase activity of Raf-1Activation of Raf-1Phosphorylation of Raf-1Sodium dodecyl sulfate gelsRaf-1 activationImmunocomplex kinase assayEGF signal transductionC-Raf-1Dodecyl sulfate gelsTyrosine kinase activityTyrosine phosphorylationSerine residuesHistone H1Kinase assaySignal transductionDownstream effectorsStimulated associationEGF receptorKinaseGrowth factor