2012
Poxviral vectors for cancer immunotherapy
Kim JW, Gulley JL. Poxviral vectors for cancer immunotherapy. Expert Opinion On Biological Therapy 2012, 12: 463-478. PMID: 22413824, PMCID: PMC3482162, DOI: 10.1517/14712598.2012.668516.Peer-Reviewed Original ResearchConceptsAppropriate patient selectionClinical trial designPatient selectionTrial designMetastatic castration-resistant prostate cancerPlacebo-controlled clinical trialCastration-resistant prostate cancerNovel immunologic approachesPhase III randomizedScience of immunotherapyImmune-based therapiesMultiple costimulatory moleculesTumor-associated antigensEarly clinical studiesAppropriate end pointsPoxviral vaccinesPSA-TRICOMHormonal therapyNovel immunotherapiesPoxviral vectorsCancer vaccinesCostimulatory moleculesCancer immunotherapyTreatment modalitiesImmunologic approaches
2010
Chemoprevention of Head and Neck Cancer with Green Tea Polyphenols
Kim JW, Amin AR, Shin DM. Chemoprevention of Head and Neck Cancer with Green Tea Polyphenols. Cancer Prevention Research 2010, 3: 900-909. PMID: 20663981, PMCID: PMC2917478, DOI: 10.1158/1940-6207.capr-09-0131.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaGreen tea polyphenolsCell carcinomaNovel clinical trial designsTea polyphenolsChemoprevention of headHigh-risk patientsKey molecular signaling pathwaysClinical trial designNatural dietary compoundsUse of biomarkersMolecular signaling pathwaysNeck cancerChemoprevention researchChemopreventive agentsDietary compoundsTrial designCarcinomaChemopreventionSignaling pathwaysAdditive effectNatural compoundsEGCGMajor advancesPolyphenols
2006
Transferable anticancer innate immunity in spontaneous regression/complete resistance mice
Hicks AM, Riedlinger G, Willingham MC, Alexander-Miller MA, Von Kap-Herr C, Pettenati MJ, Sanders AM, Weir HM, Du W, Kim J, Simpson AJ, Old LJ, Cui Z. Transferable anticancer innate immunity in spontaneous regression/complete resistance mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 7753-7758. PMID: 16682640, PMCID: PMC1458507, DOI: 10.1073/pnas.0602382103.Peer-Reviewed Original ResearchConceptsNatural killer cellsKiller cellsCancer cellsInnate immunitySR/CR miceWT recipient miceSubsets of leukocytesBone marrow cellsFormation of rosettesEffector cellsWT miceRecipient miceCR miceHigh dosesLow dosesPeritoneal macrophagesKilling activityMarrow cellsMiceRapid cytolysisCancer challengesLeukocytesMacrophagesDistant sitesNeutrophils