2023
THU302 Protective Effects Of Lactation On Maternal Metabolism
Hens J, Ding Y, Brown S, Song H, Wysolmerski J, De Aguiar R. THU302 Protective Effects Of Lactation On Maternal Metabolism. Journal Of The Endocrine Society 2023, 7: bvad114.737. PMCID: PMC10554876, DOI: 10.1210/jendso/bvad114.737.Peer-Reviewed Original ResearchNL miceGlucose metabolismL miceBody compositionEuglycemic hyperinsulinemic clamp techniquePlasma free fatty acidsHistory of lactationMaternal glucose metabolismTissue triglyceride levelsGlucose tolerance testType 2 diabetesEuglycemic hyperinsulinemic clampGlucose infusion rateAge-matched cohortNumber of isletsAge-matched virginsLiver triglyceridesInsulin levelsTriglyceride levelsLiver weightTolerance testInsulin secretionMaternal metabolismFree fatty acidsInfusion rate
2022
Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice.
Saleh FL, Joshi AA, Tal A, Xu P, Hens J, Wong SL, Flannery C. Hyperinsulinemia induces early and dyssynchronous puberty in lean female mice. Journal Of Endocrinology 2022, 254: 121-135. PMID: 35904489, PMCID: PMC9837806, DOI: 10.1530/joe-21-0447.Peer-Reviewed Original ResearchConceptsVaginal openingInsulin resistanceDay of VOIGF-1 levelsInsulin-like growth factor 1 receptorGreater insulin resistanceHigher insulin levelsEffect of hyperinsulinemiaGrowth factor 1 receptorGonadotropin-releasing hormoneLower body weightFactor 1 receptorReceptor isoform expressionMammary gland developmentLH levelsInsulin levelsInsulin receptor isoform expressionKisspeptin expressionChildhood obesityFemale miceHormone levelsEarly initiationHyperinsulinemiaBody weightOvarian follicles