Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
Hens JR, Sinha I, Perodin F, Cooper T, Sinha R, Plummer J, Perrone CE, Orentreich D. Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice. BMC Cancer 2016, 16: 349. PMID: 27255182, PMCID: PMC4891836, DOI: 10.1186/s12885-016-2367-1.Peer-Reviewed Original ResearchConceptsMethionine restrictionMR miceMR dietCell cycle inhibitorsNude micePlasma amino acid concentrationsBreast cancer xenograft modelCancer xenograft modelAthymic nude miceBreast cancer cell linesTumors of miceCycle inhibitorsMDA-MB-231 cellsConventional cancer therapiesAqueous One Solution Cell ProliferationCell Titer 96MDA-MB-231Cancer cell linesProgression of cancerInsulin sensitivityMammary gland tissuePlasma concentrationsMammary tumorsSmall tumorsAmino acid concentrationsMethionine restriction beyond life‐span extension
Ables GP, Hens JR, Nichenametla SN. Methionine restriction beyond life‐span extension. Annals Of The New York Academy Of Sciences 2016, 1363: 68-79. PMID: 26916321, DOI: 10.1111/nyas.13014.Peer-Reviewed Original ResearchConceptsMethionine restrictionLife span extensionPossible downstream effectorsMitochondrial oxidative stressAge-related diseasesCystathionine β-synthaseIntracellular regulatory mechanismsEpigenetic mechanismsNoncoding RNAsDownstream effectorsSpecific genesReactive oxygen speciesRegulatory mechanismsCell cycleBody sizeMethionine cycleEpigeneticsCancer progressionΒ-synthaseDietary methionine restrictionCell apoptosisFactor 1Fibroblast growth factor 21Hepatic glucose metabolismInsulin-like growth factor-1