2023
Concurrent carboplatin and paclitaxel definitive radiation therapy for locally advanced head and neck cancer
Han J, Zakeri K, Raab G, Hesse J, Shamseddine A, Chen L, Yu Y, Kang J, McBride S, Riaz N, Tsai C, Gelblum D, Sherman E, Wong R, Michel L, Lee N. Concurrent carboplatin and paclitaxel definitive radiation therapy for locally advanced head and neck cancer. Head & Neck 2023, 45: 2207-2216. PMID: 37439286, PMCID: PMC10981461, DOI: 10.1002/hed.27456.Peer-Reviewed Original ResearchConceptsLocoregional recurrenceDistant metastasisOverall survivalHNSCC patientsConcurrent carboplatinDefinitive chemoradiationConsecutive HNSCC patientsDefinitive radiation therapyMedian radiation doseKaplan-Meier methodCumulative incidence functionFree survivalAdvanced headMedian ageMedian dosesNeck cancerAUC 1Radiation therapyCarboplatinPatientsChemoradiationPaclitaxelRadiation doseExcellent optionIncidence function
2022
Peer Review of Head and Neck Cancer Planning Target Volumes in Radiation Oncology
Hesse J, Zakeri K, Chen L, Yu Y, Kang J, Riaz N, Tsai C, McBride S, Gelblum D, Lee N. Peer Review of Head and Neck Cancer Planning Target Volumes in Radiation Oncology. International Journal Of Radiation Oncology • Biology • Physics 2022, 114: e472-e473. DOI: 10.1016/j.ijrobp.2022.07.1729.Peer-Reviewed Original ResearchStart of RTTarget volumeFurther workupNeck cancerTreatment planPositive findingsNeck radiation oncologistMinority of patientsOverall treatment planTreatment planningPlanning target volumeProspective peer reviewTumor board discussionMATERIAL/METHODSNeck cancer casesRadiation treatment plansFurther surgeryUnderwent biopsyAdditional surgeryAdditional workupOncology servicesSignificant changesCancer casesPatientsRadiation oncologistsNasal Cavity and Paranasal Sinus Tumors
Fan M, Yu Y, Kang J, Lee N. Nasal Cavity and Paranasal Sinus Tumors. Practical Guides In Radiation Oncology 2022, 87-98. DOI: 10.1007/978-3-030-99590-4_7.Peer-Reviewed Original ResearchParanasal sinusesNasal cavityTumor typesTarget delineationExperienced multidisciplinary teamSquamous cell carcinomaParanasal sinus tumorsDifferent natural historyCentral nervous systemMedical oncologistsSinus tumorAccurate target delineationCell carcinomaOptimal careNeck surgeonsCystic carcinomaNervous systemDiverse tumor typesMultidisciplinary teamRadiation oncologistsSkull baseNatural historyPatientsCarcinomaOncologistsPeer Review of Head and Neck Cancer Planning Target Volumes in Radiation Oncology
Hesse J, Chen L, Yu Y, Kang J, Riaz N, Tsai C, McBride S, Gelblum D, Zakeri K, Lee N. Peer Review of Head and Neck Cancer Planning Target Volumes in Radiation Oncology. Advances In Radiation Oncology 2022, 7: 100917. PMID: 35647395, PMCID: PMC9133360, DOI: 10.1016/j.adro.2022.100917.Peer-Reviewed Original ResearchStart of RTAdditional workupTarget volumeAdditional surgeryNeck cancerTreatment planPositive findingsNeck radiation oncologistMinority of patientsOverall treatment planTreatment planningPlanning target volumeProspective peer reviewTumor board discussionNeck cancer casesRadiation treatment plansUnderwent biopsyMedical oncologistsSignificant changesCancer casesAdditional consultationPatientsRadiation oncologistsRadiation therapy planningTreatment volume
2021
The effect of short radiation treatment breaks on chemo‐radiotherapy for oropharyngeal cancers
Rybkin A, Kang JJ, Lee A, Kitpanit S, Fan M, Mohamed N, Cartano O, Zakeri K, Gelblum D, Sherman E, Dunn L, Boyle J, Wong R, Chen L, Yu Y, McBride SM, Tsai CJ, Riaz N, Lee NY. The effect of short radiation treatment breaks on chemo‐radiotherapy for oropharyngeal cancers. Head & Neck 2021, 43: 3796-3809. PMID: 34585792, PMCID: PMC9414892, DOI: 10.1002/hed.26879.Peer-Reviewed Original ResearchConceptsRadiation treatment breaksOropharyngeal squamous cell carcinomaOverall treatment timeTreatment breaksClinical outcomesDefinitive concurrent chemoradiotherapySquamous cell carcinomaConcurrent chemoradiotherapyOPSCC patientsOropharyngeal cancerDisease failureCell carcinomaNeck cancerCancer recurrenceConsecutive cohortMultivariate analysisSignificant associationPatientsCancerFurther investigationProlongationDaysOutcomesNumerous studiesChemoradiotherapyProton radiotherapy for recurrent or metastatic sarcoma with palliative quad shot
Lee A, Kang J, Bernstein H, Marqueen K, Neal B, Kelly C, Dickson M, Tsai C, Tap W, Singer S, Alektiar K, Lee N. Proton radiotherapy for recurrent or metastatic sarcoma with palliative quad shot. Cancer Medicine 2021, 10: 4221-4227. PMID: 34085781, PMCID: PMC8267151, DOI: 10.1002/cam4.3646.Peer-Reviewed Original ResearchConceptsLocal progression-free survivalMetastatic sarcomaSystemic therapyQUAD ShotOverall survivalUnivariate analysisPalliative responseMedian local progression-free survivalGrade 3 acute toxicityFurther systemic therapyProgression-free survivalConcurrent systemic therapyProton therapyCommon histologyMedian followProton RTTreatment optionsRadiation therapyPatientsLocal controlSarcomaTherapyRegimenProton radiotherapyAcute toxicityOutcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy
Zakeri K, Wang H, Kang JJ, Lee A, Romesser P, Mohamed N, Gelblum D, Sherman E, Dunn L, Boyle J, Wong R, Chen L, Yu Y, Tsai CJ, McBride SM, Riaz N, Lee N. Outcomes and prognostic factors of major salivary gland tumors treated with proton beam radiation therapy. Head & Neck 2021, 43: 1056-1062. PMID: 33606323, PMCID: PMC9371938, DOI: 10.1002/hed.26563.Peer-Reviewed Original ResearchConceptsMajor salivary gland tumorsProton beam radiation therapyBeam radiation therapySalivary gland tumorsRadiation therapyLocoregional controlGland tumorsProgression-free survivalPhoton radiation therapyOverall survivalPrognostic factorsCommon siteCystic carcinomaLarge cohortDosimetric advantagesParotid glandTherapyPatientsTumorsTherapy CenterSurvivalTreatmentProton Therapy CenterCarcinomaCohortImpact of Telemedicine on Patient Satisfaction and Perceptions of Care Quality in Radiation Oncology.
Shaverdian N, Gillespie EF, Cha E, Kim SY, Benvengo S, Chino F, Kang JJ, Li Y, Atkinson TM, Lee N, Washington CM, Cahlon O, Gomez DR. Impact of Telemedicine on Patient Satisfaction and Perceptions of Care Quality in Radiation Oncology. Journal Of The National Comprehensive Cancer Network 2021, 19: 1174-1180. PMID: 33395627, PMCID: PMC8254817, DOI: 10.6004/jnccn.2020.7687.Peer-Reviewed Original ResearchConceptsOffice visitsQuality of carePatient satisfactionRadiation oncology practiceOncology practiceTelemedicine consultationsGood performance statusPatient Experience QuestionnaireHigh patient satisfactionComprehensive cancer centerPatient-oncologist communicationImpact of telemedicineSurvey response ratePerformance statusTelemedicine visitsCancer CenterCancer careVisit typePhysicians' concernsPatient experiencePhysicians' explanationsPatientsResponse rateTreatment planSatisfaction scores
2020
Beyond reirradiation: Efficacy and safety of three or more courses of radiation for head and neck malignancies
Xu AJ, Luo L, Leeman JE, Romesser PB, Spielsinger D, Sabol C, Waldenberg T, Brinkman T, Riaz N, McBride S, Kang J, Lee N, Tsai CJ. Beyond reirradiation: Efficacy and safety of three or more courses of radiation for head and neck malignancies. Clinical And Translational Radiation Oncology 2020, 23: 30-34. PMID: 32382663, PMCID: PMC7200775, DOI: 10.1016/j.ctro.2020.04.009.Peer-Reviewed Original ResearchCourse of radiationMedian local recurrence-free survivalNeck regionLocal recurrence-free survivalGrade 5 toxicityMedian overall survivalRecurrence-free survivalSingle-institution databaseFree survivalOverall survivalSelect patientsSystemic therapyNeck malignanciesRecurrent headSignificant morbiditySubsequent therapyNeck cancerMulti-disciplinary teamGrade 3Institution's databasePatientsLocal controlReirradiationTreatment planMultiple coursesClinical Outcomes and Toxicities in Oropharyngeal Cancer (OPC) Patients Treated with Proton Therapy: A Single Institutional Experience
Kitpanit S, Lee A, Fan D, Fan M, Wang H, Mohamed N, Spielsinger D, Gelblum D, Sherman E, Dunn L, Boyle J, Wong R, Cohen M, Kang J, Tsai C, McBride S, Zakeri K, Chen L, Yu Y, Riaz N, Lee N. Clinical Outcomes and Toxicities in Oropharyngeal Cancer (OPC) Patients Treated with Proton Therapy: A Single Institutional Experience. International Journal Of Radiation Oncology • Biology • Physics 2020, 106: 1152-1153. DOI: 10.1016/j.ijrobp.2019.11.231.Peer-Reviewed Original ResearchTemporal Lobe Necrosis in Head and Neck Cancer Patients after Proton Therapy to the Skull Base
Kitpanit S, Lee A, Pitter KL, Fan D, Chow JCH, Neal B, Han Z, Fox P, Sine K, Mah D, Dunn LA, Sherman EJ, Michel L, Ganly I, Wong RJ, Boyle JO, Cohen MA, Singh B, Brennan CW, Gavrilovic IT, Hatzoglou V, O'Malley B, Zakeri K, Yu Y, Chen L, Gelblum DY, Kang JJ, McBride SM, Tsai CJ, Riaz N, Lee NY. Temporal Lobe Necrosis in Head and Neck Cancer Patients after Proton Therapy to the Skull Base. International Journal Of Particle Therapy 2020, 6: 17-28. PMID: 32582816, PMCID: PMC7302730, DOI: 10.14338/ijpt-20-00014.1.Peer-Reviewed Original ResearchMagnetic resonance imagingRadiation-naïve patientsDose-volume parametersSkull baseNeck cancerTemporal lobeCutoff valueMaximum doseProton therapyAdverse Events v5.0Common Terminology CriteriaTemporal lobe necrosisNeck cancer patientsDose-volume factorsTerminology CriteriaMedian followBrain necrosisMedian timeClinical parametersCancer patientsMedical recordsGrade 3Necrosis rateField of radiationPatientsOutcomes and toxicities of definitive radiotherapy and reirradiation using 3‐dimensional conformal or intensity‐modulated (pencil beam) proton therapy for patients with nasal cavity and paranasal sinus malignancies
Fan M, Kang JJ, Lee A, Fan D, Wang H, Kitpanit S, Fox P, Sine K, Mah D, McBride SM, Tsai CJ, Riaz N, Dunn LA, Sherman EJ, Michel L, Singh B, Ganly I, Wong RJ, Boyle JO, Cohen MA, Lee NY. Outcomes and toxicities of definitive radiotherapy and reirradiation using 3‐dimensional conformal or intensity‐modulated (pencil beam) proton therapy for patients with nasal cavity and paranasal sinus malignancies. Cancer 2020, 126: 1905-1916. PMID: 32097507, PMCID: PMC7304541, DOI: 10.1002/cncr.32776.Peer-Reviewed Original ResearchConceptsGrade 3 toxicityRadiation-naive patientsIntensity-modulated proton therapyLate grade 3 toxicityParanasal sinus cancerLocal controlNasal cavitySinus cancerAcute grade 3 toxicityGray relative biological effectivenessProton therapyMore grade 1Paranasal sinus malignanciesRemarkable local controlDisease-free survivalInferior local controlOverall survival rateDefinitive radiotherapyConsecutive patientsSinus malignanciesMedian dosesHigher complicationsDistant controlTherapeutic ratioPatients
2019
Timing of surgery and adjuvant radiation therapy for sinonasal malignancies: Effect of surgical approach
Xiao R, Joshi RR, Husain Q, Cracchiolo JR, Lee N, Tsai J, Yu Y, Chen L, Kang JJ, McBride S, Riaz N, Roman BR, Ganly I, Tabar V, Gray ST, Cohen MA. Timing of surgery and adjuvant radiation therapy for sinonasal malignancies: Effect of surgical approach. Head & Neck 2019, 41: 3551-3563. PMID: 31294897, PMCID: PMC6742559, DOI: 10.1002/hed.25873.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCarcinoma, Squamous CellCombined Modality TherapyDatabases, FactualDisease-Free SurvivalEndoscopyFemaleHumansKaplan-Meier EstimateLinear ModelsMaleMiddle AgedOtorhinolaryngologic Surgical ProceduresParanasal Sinus NeoplasmsPropensity ScoreRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentSurvival AnalysisTime FactorsConceptsSquamous cell carcinomaRadiation therapyEndoscopic surgeryPropensity score-matched analysisAdjuvant radiation therapyNational Cancer DatabasePostoperative radiation therapyKaplan-Meier methodTiming of surgeryDay of surgeryShorter postoperative timeMultivariable linear regressionOverall survivalPostoperative timeSinonasal malignanciesCell carcinomaSurgical approachNeck cancerCancer DatabaseParanasal sinusesSurvival advantageNasal cavitySurgeryPatientsExtended OS