2020
Impact of radiation source activity on short- and long-term outcomes of cervical carcinoma patients treated with high-dose-rate brachytherapy: A retrospective cohort study
Li C, Li X, You J, Liang B, Su X, Huang Y, Chen Y, Hu Q, Deng J, Wang H, Pu Y, Liu H, Ma Y, Wang W, Wu H, Zhang Y. Impact of radiation source activity on short- and long-term outcomes of cervical carcinoma patients treated with high-dose-rate brachytherapy: A retrospective cohort study. Gynecologic Oncology 2020, 159: 365-372. PMID: 32933759, DOI: 10.1016/j.ygyno.2020.08.037.Peer-Reviewed Original ResearchConceptsMetastatic recurrence-free survivalLocal recurrence-free survivalCervical carcinoma patientsRecurrence-free survivalLong-term outcomesCarcinoma patientsPatient outcomesRetrospective cohort studyShort-term outcomesMedian followCohort studyIridium-192 sourceSubgroup analysisSurvival timeRate brachytherapyStage IDay 199Patients
2019
Predicting breast cancer risk using personal health data and machine learning models
Stark GF, Hart GR, Nartowt BJ, Deng J. Predicting breast cancer risk using personal health data and machine learning models. PLOS ONE 2019, 14: e0226765. PMID: 31881042, PMCID: PMC6934281, DOI: 10.1371/journal.pone.0226765.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast cancer risk predictionCancer riskCancer risk predictionGail modelBreast cancer risk prediction toolsCancer risk prediction toolsPositive breast cancer casesHormone replacement therapyRisk stratification toolRisk predictionRisk prediction toolsHealth dataBreast cancer casesPersonal health dataStratification toolReplacement therapyLeading causeBreast cancerCancer casesInvasive proceduresBCRATDeLong testLogistic regressionEarly breast cancer detectionScoring colorectal cancer risk with an artificial neural network based on self-reportable personal health data
Nartowt BJ, Hart GR, Roffman DA, Llor X, Ali I, Muhammad W, Liang Y, Deng J. Scoring colorectal cancer risk with an artificial neural network based on self-reportable personal health data. PLOS ONE 2019, 14: e0221421. PMID: 31437221, PMCID: PMC6705772, DOI: 10.1371/journal.pone.0221421.Peer-Reviewed Original ResearchConceptsNational Health Interview SurveyUnited States Preventative Services Task ForceColorectal cancerPredictive valueDiagnosis of CRCColorectal cancer riskHealth Interview SurveyHigh-risk categoryNegative predictive valuePositive predictive valueMultivariable prediction modelHealth dataUSPSTF guidelinesRisk score methodCRC riskFamily historyCancer riskHigh riskAge 50Individual prognosisLower riskPersonal health dataClinical applicabilityInterview SurveyCancer
2018
A multi-parameterized artificial neural network for lung cancer risk prediction
Hart GR, Roffman DA, Decker R, Deng J. A multi-parameterized artificial neural network for lung cancer risk prediction. PLOS ONE 2018, 13: e0205264. PMID: 30356283, PMCID: PMC6200229, DOI: 10.1371/journal.pone.0205264.Peer-Reviewed Original ResearchConceptsLung cancer risk predictionHistory of strokeNon-invasive clinical toolLung cancer riskHealth informationPersonal health informationNon-cancer casesCancer risk predictionRisk stratificationSmoking statusHeart diseaseExercise habitsHispanic ethnicityLung cancer detectionCancer riskClinical toolAdult dataRisk predictionModest sensitivityCancer detectionAUCHigh specificitySpecificityHypertensionAsthmaImaging Dose, Cancer Risk and Cost Analysis in Image-guided Radiotherapy of Cancers
Zhou L, Bai S, Zhang Y, Ming X, Zhang Y, Deng J. Imaging Dose, Cancer Risk and Cost Analysis in Image-guided Radiotherapy of Cancers. Scientific Reports 2018, 8: 10076. PMID: 29973695, PMCID: PMC6031630, DOI: 10.1038/s41598-018-28431-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBone Marrow CellsBrainChildChild, PreschoolCone-Beam Computed TomographyCost-Benefit AnalysisFemaleHumansInfantLungMaleMiddle AgedMonte Carlo MethodNeoplasmsPhantoms, ImagingRadiation DosageRadiotherapy DosageRadiotherapy, Image-GuidedRisk FactorsThoraxYoung AdultConceptsCancer riskAssociated cancer riskImage-guided radiotherapyImaging proceduresLifetime attributable riskImaging dosesAverage lifetime attributable riskRadiological imaging proceduresRed bone marrowRetrospective studyCancer patientsLung cancerAttributable riskCancer incidenceBilling codesIndividual patientsBone marrowBrain cancerImage guidance proceduresPelvic scanPatientsCancerOrgan dosesRadiotherapyDosesPredicting non-melanoma skin cancer via a multi-parameterized artificial neural network
Roffman D, Hart G, Girardi M, Ko CJ, Deng J. Predicting non-melanoma skin cancer via a multi-parameterized artificial neural network. Scientific Reports 2018, 8: 1701. PMID: 29374196, PMCID: PMC5786038, DOI: 10.1038/s41598-018-19907-9.Peer-Reviewed Original ResearchConceptsNon-melanoma skin cancerFamily historySkin cancerUVR exposureHistory of strokePotential predictive parametersNon-cancer casesFamily history informationUltraviolet radiation exposureDiabetic statusSmoking statusHeart diseaseRisk factorsExercise habitsHispanic ethnicityPredictive parametersAdult survey dataEarly detectionRadiation exposureROC curveHealth informationPersonal health informationNovel associationsCancerExposure
2016
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study
Zhang Y, Feng Y, Ming X, Deng J. Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study. BioMed Research International 2016, 2016: 7319843. PMID: 26977413, PMCID: PMC4763028, DOI: 10.1155/2016/7319843.Peer-Reviewed Original ResearchConceptsIMRT plansPediatric brain tumorsNovel treatment modalitiesNormal tissue sparingDifferent tumor sitesDosimetric gainLung cancerTreatment modalitiesIndividual patientsBrain tumorsTissue sparingIMRT techniqueTumor sitePersonalized carePhoton radiotherapyThyroid lesionsDose distributionIntegral doseRadiotherapy treatmentInverse planning systemPatientsRadiotherapyFeasibility studyModern radiotherapy treatmentsClinical IMRT plans
2015
Cardiac Exposure in the Dynamic Conformal Arc Therapy, Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy of Lung Cancer
Ming X, Feng Y, Liu H, Zhang Y, Zhou L, Deng J. Cardiac Exposure in the Dynamic Conformal Arc Therapy, Intensity-Modulated Radiotherapy and Volumetric Modulated Arc Therapy of Lung Cancer. PLOS ONE 2015, 10: e0144211. PMID: 26630566, PMCID: PMC4667972, DOI: 10.1371/journal.pone.0144211.Peer-Reviewed Original ResearchConceptsDynamic conformal arc therapyLung cancer patientsIntensity-modulated radiotherapyIrradiated heart volumeCardiac exposureHeart distanceConformal arc therapyCancer patientsHeart volumeArc therapyHeart doseCardiac diseaseLong-term cardiac toxicityMean heart doseMean heart dosesRight lung tumorLung cancer treatmentVolumetric Modulated Arc TherapyRadiotherapy treatment modalitiesInstitutional review boardLung cancer radiotherapyHeart dosesHeart sparingCardiac complicationsHodgkin's diseaseConcomitant Imaging Dose and Cancer Risk in Image Guided Thoracic Radiation Therapy
Zhang Y, Wu H, Chen Z, Knisely JP, Nath R, Feng Z, Bao S, Deng J. Concomitant Imaging Dose and Cancer Risk in Image Guided Thoracic Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 523-531. PMID: 26460994, DOI: 10.1016/j.ijrobp.2015.06.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAorta, ThoracicBody SizeBreastChildChild, PreschoolCone-Beam Computed TomographyFemaleHeartHumansLungMaleMiddle AgedMonte Carlo MethodOrgans at RiskPhantoms, ImagingPhotonsPrecision MedicineProtonsRadiation DosageRadiography, ThoracicRadiotherapy, Image-GuidedRisk AssessmentSex FactorsSpinal CordThoracic WallThoraxConceptsConcomitant imaging doseThoracic radiation therapyCancer riskRadiation therapyMean dosesCardiac substructuresKilovoltage cone-beamImaging doseAdverse eventsPediatric patientsMedian dosesCancer patientsRight ventricleExtra radiation doseSpinal cordHigh dosesPatientsCone beamPlanning CT imagesChest dimensionsDosesPatient sizeImaging guidanceTherapyDose
2012
CT scans in childhood and risk of leukaemia and brain tumours
Deng J, Zhang Y, Nath R, Bao S. CT scans in childhood and risk of leukaemia and brain tumours. The Lancet 2012, 380: 1735. PMID: 23158242, DOI: 10.1016/s0140-6736(12)61980-1.Peer-Reviewed Original ResearchPersonalized estimation of dose to red bone marrow and the associated leukaemia risk attributable to pelvic kilo-voltage cone beam computed tomography scans in image-guided radiotherapy
Zhang Y, Yan Y, Nath R, Bao S, Deng J. Personalized estimation of dose to red bone marrow and the associated leukaemia risk attributable to pelvic kilo-voltage cone beam computed tomography scans in image-guided radiotherapy. Physics In Medicine And Biology 2012, 57: 4599-4612. PMID: 22750636, DOI: 10.1088/0031-9155/57/14/4599.Peer-Reviewed Original ResearchConceptsKilo-voltage cone beamRed bone marrowLeukemia riskRBM doseImage-guided radiation therapyTomography scanBone marrowCone beamRadiogenic cancer riskRadiation therapy courseCancer patientsBone densityImage-guided radiotherapyRadiation therapyCancer riskHigh riskPersonalized estimationAnthropometric variablesTherapy courseDoseSubject groupsDosesBone dosesScansPatientsPersonalized Assessment of kV Cone Beam Computed Tomography Doses in Image-guided Radiotherapy of Pediatric Cancer Patients
Zhang Y, Yan Y, Nath R, Bao S, Deng J. Personalized Assessment of kV Cone Beam Computed Tomography Doses in Image-guided Radiotherapy of Pediatric Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2012, 83: 1649-1654. PMID: 22285667, DOI: 10.1016/j.ijrobp.2011.10.072.Peer-Reviewed Original ResearchAdolescentAge FactorsBody SizeBody WeightChildChild, PreschoolCone-Beam Computed TomographyFemaleHeadHumansMaleMonte Carlo MethodNeoplasmsOrgans at RiskPelvisPhantoms, ImagingRadiation DosageRadiation InjuriesRadiotherapy Planning, Computer-AssistedRadiotherapy, Image-GuidedRetrospective StudiesYoung Adult
2011
Kilovoltage Imaging Doses in the Radiotherapy of Pediatric Cancer Patients
Deng J, Chen Z, Roberts KB, Nath R. Kilovoltage Imaging Doses in the Radiotherapy of Pediatric Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2011, 82: 1680-1688. PMID: 21477943, DOI: 10.1016/j.ijrobp.2011.01.062.Peer-Reviewed Original ResearchConceptsPediatric cancer patientsCancer patientsTesticular shieldingSpinal cordKilovoltage cone-beamCBCT dosesMean dosesClinical conditionsDose reductionLarge dosesFemoral headPatientsCBCT scansCone beamDosesFull-fan modeOptical nerveCBCT fieldCordDose increaseImaging dosesScanning protocolOARsRadiotherapyHalf-fan mode
2000
Energy- and intensity-modulated electron beams for radiotherapy
Ma C, Pawlicki T, Lee MC, Jiang SB, Li JS, Deng J, Yi B, Mok E, Boyer AL. Energy- and intensity-modulated electron beams for radiotherapy. Physics In Medicine And Biology 2000, 45: 2293-2311. PMID: 10958195, DOI: 10.1088/0031-9155/45/8/316.Peer-Reviewed Original ResearchConceptsModulated electron radiotherapyIntensity-modulated electron beamElectron beamMultileaf collimatorElectron beam energyInter-leaf leakageDose distributionElectron intraMonte Carlo dose calculationsPencil beam algorithmLeaf endsBeam energyPhoton beamsElectron radiotherapyOblique incidencePatient surfaceMonte Carlo methodBeamBeam algorithmField shapeMonte Carlo simulationsDose calculationsSuperficial targetsCarlo methodCarlo simulations