2020
A general-purpose Monte Carlo particle transport code based on inverse transform sampling for radiotherapy dose calculation
Liang Y, Muhammad W, Hart GR, Nartowt BJ, Chen ZJ, Yu JB, Roberts KB, Duncan JS, Deng J. A general-purpose Monte Carlo particle transport code based on inverse transform sampling for radiotherapy dose calculation. Scientific Reports 2020, 10: 9808. PMID: 32555530, PMCID: PMC7300009, DOI: 10.1038/s41598-020-66844-7.Peer-Reviewed Original ResearchConceptsPhoton transportBoundary crossing algorithmMonte Carlo particle transport codeMonte Carlo methodTransport simulationsAcceptance-rejection samplingRadiotherapy dose calculationsPhoto-electric effectParticle transport codeEGSnrc simulationsCarlo methodBremsstrahlung eventsInelastic scatteringPair productionRayleigh scatteringThread divergenceMC simulationsTransport codeMC codeHistory schemeParticle transportCrossing algorithmInverseElectron transportSimulation accuracy
2019
Beam modeling and beam model commissioning for Monte Carlo dose calculation‐based radiation therapy treatment planning: Report of AAPM Task Group 157
Charlie C, Chetty IJ, Deng J, Faddegon B, Jiang SB, Li J, Seuntjens J, Siebers JV, Traneus E. Beam modeling and beam model commissioning for Monte Carlo dose calculation‐based radiation therapy treatment planning: Report of AAPM Task Group 157. Medical Physics 2019, 47: e1-e18. PMID: 31679157, DOI: 10.1002/mp.13898.Peer-Reviewed Original ResearchMeSH KeywordsModels, TheoreticalMonte Carlo MethodRadiation DosageRadiotherapy DosageRadiotherapy Planning, Computer-AssistedResearch ReportConceptsBeam modelElectron beam dose calculationsMonte Carlo methodRadiotherapy dose calculationsTreatment planning systemDose calculationsClinical beam modelCarlo methodBeam modelingRadiation therapy treatment planningMC simulationsTherapy treatment planningElectron beamTreatment headClinical photonRadiotherapy treatment planningGeneral approachCalculationsHigh accuracyPractical procedureAccuracyModelClinical physicistsAnalytical methodBeam delivery
2018
Imaging Dose, Cancer Risk and Cost Analysis in Image-guided Radiotherapy of Cancers
Zhou L, Bai S, Zhang Y, Ming X, Zhang Y, Deng J. Imaging Dose, Cancer Risk and Cost Analysis in Image-guided Radiotherapy of Cancers. Scientific Reports 2018, 8: 10076. PMID: 29973695, PMCID: PMC6031630, DOI: 10.1038/s41598-018-28431-9.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBone Marrow CellsBrainChildChild, PreschoolCone-Beam Computed TomographyCost-Benefit AnalysisFemaleHumansInfantLungMaleMiddle AgedMonte Carlo MethodNeoplasmsPhantoms, ImagingRadiation DosageRadiotherapy DosageRadiotherapy, Image-GuidedRisk FactorsThoraxYoung AdultConceptsCancer riskAssociated cancer riskImage-guided radiotherapyImaging proceduresLifetime attributable riskImaging dosesAverage lifetime attributable riskRadiological imaging proceduresRed bone marrowRetrospective studyCancer patientsLung cancerAttributable riskCancer incidenceBilling codesIndividual patientsBone marrowBrain cancerImage guidance proceduresPelvic scanPatientsCancerOrgan dosesRadiotherapyDoses
2017
A measurement-based generalized source model for Monte Carlo dose simulations of CT scans
Ming X, Feng Y, Liu R, Yang C, Zhou L, Zhai H, Deng J. A measurement-based generalized source model for Monte Carlo dose simulations of CT scans. Physics In Medicine And Biology 2017, 62: 1759-1776. PMID: 28079526, PMCID: PMC5857954, DOI: 10.1088/1361-6560/aa5911.Peer-Reviewed Original ResearchConceptsMonte Carlo dose simulationsGeneralized source modelEnergy spectrumFluence distributionDose profilesCentral axis percent depth dose curvePercent depth dose curvesDose simulationsDepth dose curvesMonte Carlo user codeSource distributionBeam inputDose curvesFilm measurementsCTDI phantomCT scannerOutput factorsAbsolute dose comparisonsMonte Carlo simulationsDose distributionSource modelCarlo simulationsCircular sourceGE LightspeedScanner specifications
2016
Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study
Zhang Y, Feng Y, Ming X, Deng J. Energy Modulated Photon Radiotherapy: A Monte Carlo Feasibility Study. BioMed Research International 2016, 2016: 7319843. PMID: 26977413, PMCID: PMC4763028, DOI: 10.1155/2016/7319843.Peer-Reviewed Original ResearchConceptsIMRT plansPediatric brain tumorsNovel treatment modalitiesNormal tissue sparingDifferent tumor sitesDosimetric gainLung cancerTreatment modalitiesIndividual patientsBrain tumorsTissue sparingIMRT techniqueTumor sitePersonalized carePhoton radiotherapyThyroid lesionsDose distributionIntegral doseRadiotherapy treatmentInverse planning systemPatientsRadiotherapyFeasibility studyModern radiotherapy treatmentsClinical IMRT plans
2015
Concomitant Imaging Dose and Cancer Risk in Image Guided Thoracic Radiation Therapy
Zhang Y, Wu H, Chen Z, Knisely JP, Nath R, Feng Z, Bao S, Deng J. Concomitant Imaging Dose and Cancer Risk in Image Guided Thoracic Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2015, 93: 523-531. PMID: 26460994, DOI: 10.1016/j.ijrobp.2015.06.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overAorta, ThoracicBody SizeBreastChildChild, PreschoolCone-Beam Computed TomographyFemaleHeartHumansLungMaleMiddle AgedMonte Carlo MethodOrgans at RiskPhantoms, ImagingPhotonsPrecision MedicineProtonsRadiation DosageRadiography, ThoracicRadiotherapy, Image-GuidedRisk AssessmentSex FactorsSpinal CordThoracic WallThoraxConceptsConcomitant imaging doseThoracic radiation therapyCancer riskRadiation therapyMean dosesCardiac substructuresKilovoltage cone-beamImaging doseAdverse eventsPediatric patientsMedian dosesCancer patientsRight ventricleExtra radiation doseSpinal cordHigh dosesPatientsCone beamPlanning CT imagesChest dimensionsDosesPatient sizeImaging guidanceTherapyDose
2012
Personalized Assessment of kV Cone Beam Computed Tomography Doses in Image-guided Radiotherapy of Pediatric Cancer Patients
Zhang Y, Yan Y, Nath R, Bao S, Deng J. Personalized Assessment of kV Cone Beam Computed Tomography Doses in Image-guided Radiotherapy of Pediatric Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2012, 83: 1649-1654. PMID: 22285667, DOI: 10.1016/j.ijrobp.2011.10.072.Peer-Reviewed Original ResearchAdolescentAge FactorsBody SizeBody WeightChildChild, PreschoolCone-Beam Computed TomographyFemaleHeadHumansMaleMonte Carlo MethodNeoplasmsOrgans at RiskPelvisPhantoms, ImagingRadiation DosageRadiation InjuriesRadiotherapy Planning, Computer-AssistedRadiotherapy, Image-GuidedRetrospective StudiesYoung Adult
2011
Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer
Deng J, Chen Z, Yu JB, Roberts KB, Peschel RE, Nath R. Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2011, 82: e39-e47. PMID: 21489702, DOI: 10.1016/j.ijrobp.2011.01.071.Peer-Reviewed Original ResearchConceptsImage-guided radiotherapyTesticular dosesFull-fan modeProstate cancerFemoral headLess doseCBCT scansHalf-fan modeProstate cancer patientsKilovoltage cone-beamCancer patientsIntensity-modulated radiotherapy (IMRT) treatmentKilovoltage CBCTSuperior-inferior directionCone beamDosesCBCT fieldProstate patientsRectumDoseProstateMore doseRadiotherapy treatmentPatientsRadiotherapyKilovoltage Imaging Doses in the Radiotherapy of Pediatric Cancer Patients
Deng J, Chen Z, Roberts KB, Nath R. Kilovoltage Imaging Doses in the Radiotherapy of Pediatric Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2011, 82: 1680-1688. PMID: 21477943, DOI: 10.1016/j.ijrobp.2011.01.062.Peer-Reviewed Original ResearchConceptsPediatric cancer patientsCancer patientsTesticular shieldingSpinal cordKilovoltage cone-beamCBCT dosesMean dosesClinical conditionsDose reductionLarge dosesFemoral headPatientsCBCT scansCone beamDosesFull-fan modeOptical nerveCBCT fieldCordDose increaseImaging dosesScanning protocolOARsRadiotherapyHalf-fan mode
2008
Clinical implementation of enhanced dynamic wedges into the Pinnacle treatment planning system: Monte Carlo validation and patient-specific QA
Ahmad M, Deng J, Lund MW, Chen Z, Kimmett J, Moran MS, Nath R. Clinical implementation of enhanced dynamic wedges into the Pinnacle treatment planning system: Monte Carlo validation and patient-specific QA. Physics In Medicine And Biology 2008, 54: 447-465. PMID: 19098353, DOI: 10.1088/0031-9155/54/2/018.Peer-Reviewed Original Research
2004
Modelling 6 MV photon beams of a stereotactic radiosurgery system for Monte Carlo treatment planning
Deng J, Guerrero T, Ma C, Nath R. Modelling 6 MV photon beams of a stereotactic radiosurgery system for Monte Carlo treatment planning. Physics In Medicine And Biology 2004, 49: 1689-1704. PMID: 15152924, DOI: 10.1088/0031-9155/49/9/007.Peer-Reviewed Original ResearchMeSH KeywordsModels, TheoreticalMonte Carlo MethodParticle AcceleratorsPhantoms, ImagingPhotonsRadiosurgeryRadiotherapy DosageConceptsMV photon beamMonte Carlo treatmentPhoton beamsPhase spaceEGS4/BEAM systemPercent depth dose curvesParticle phase spaceMonte Carlo treatment planningDepth dose curvesFull phase spaceDose calculationsStereotactic radiosurgery systemContaminant electronsCircular planar sourceMonte Carlo systemPrimary photonsMultiple source modelDose profilesSecondary collimatorDose curvesTotal maximum doseDose contributionBeamBeam systemOriginal phase space
2003
Commissioning 6 MV photon beams of a stereotactic radiosurgery system for Monte Carlo treatment planning
Deng J, Ma C, Hai J, Nath R. Commissioning 6 MV photon beams of a stereotactic radiosurgery system for Monte Carlo treatment planning. Medical Physics 2003, 30: 3124-3134. PMID: 14713079, DOI: 10.1118/1.1624753.Peer-Reviewed Original ResearchConceptsMonte Carlo dose calculationsMonte Carlo treatment planningBeam phase spaceOutput factorsCentral axis depth dose curvesDose profilesMonte Carlo treatmentMeasurement dataMultiple source modelCyberknife stereotactic radiosurgery systemPhase spaceMV photon beamDepth dose curvesDose calculationsSource modelStereotactic radiosurgery systemFluence distributionStandard measurement dataSource distributionPhoton beamsAxis distanceEnergy spectrumCollimator sizeDose curvesAveraging effect
2002
A Monte Carlo investigation of fluence profiles collimated by an electron specific MLC during beam delivery for modulated electron radiation therapy
Deng J, Lee MC, Ma C. A Monte Carlo investigation of fluence profiles collimated by an electron specific MLC during beam delivery for modulated electron radiation therapy. Medical Physics 2002, 29: 2472-2483. PMID: 12462711, DOI: 10.1118/1.1513160.Peer-Reviewed Original ResearchConceptsFluence profilesVarian Clinac 2100C linear acceleratorElectron radiation therapyElectron beamMonte Carlo methodBeam energyBeam deliveryMonte Carlo investigationElectron beam energyCarlo methodMonte CarloOff-axis locationBEAM codeSigmoid functionLeaf endsEnergy dependenceInverse planning algorithmLinear acceleratorVariable energyMLC aperturesOperatorsBeamField sizeDose distributionMultileaf collimatorA Monte Carlo dose calculation tool for radiotherapy treatment planning
Ma C, Li JS, Pawlicki T, Jiang SB, Deng J, Lee MC, Koumrian T, Luxton M, Brain S. A Monte Carlo dose calculation tool for radiotherapy treatment planning. Physics In Medicine And Biology 2002, 47: 1671-1689. PMID: 12069086, DOI: 10.1088/0031-9155/47/10/305.Peer-Reviewed Original Research
2001
Monte Carlo based treatment planning for modulated electron beam radiation therapy
Lee M, Deng J, Li J, Jiang S, Ma C. Monte Carlo based treatment planning for modulated electron beam radiation therapy. Physics In Medicine And Biology 2001, 46: 2177-2199. PMID: 11512618, DOI: 10.1088/0031-9155/46/8/310.Peer-Reviewed Original ResearchConceptsElectron multileaf collimatorIntensity mapsDose distributionElectron radiation therapyElectron beamletsElectron energyElectron beam radiation therapyAir scatteringMonte CarloBremsstrahlung contributionConformal dose distributionsMonte Carlo simulationsBeamletsScatter dosesTreatment planning systemElectronsMultileaf collimatorCarlo simulationsBreast plansIrregular targetsLeaf transportCarloScatteringMonte Carlo generationCollimatorDerivation of electron and photon energy spectra from electron beam central axis depth dose curves
Deng J, Jiang S, Pawlicki T, Li J, Ma C. Derivation of electron and photon energy spectra from electron beam central axis depth dose curves. Physics In Medicine And Biology 2001, 46: 1429-1449. PMID: 11384063, DOI: 10.1088/0031-9155/46/5/308.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsElectronsImage Processing, Computer-AssistedLeast-Squares AnalysisMonte Carlo MethodPhotonsRadiotherapy Planning, Computer-AssistedConceptsPhoton energy spectrumDepth dose curvesCentral axis depth dose curvesPhase-space simulationsElectron beamEnergy spectrumDose curvesElectron beam dose calculationsLinear accelerator treatment headCentral axis percentage depth-dose (PDD) curvesPercentage depth dose curvesDerivation of electronPhase space dataClinical electron beamsMeV electron beamSpace simulationTreatment headPDD curvesDose profilesElectronsBeamCorresponding spectraPhotonsDose calculationsSpectraThe MLC tongue-and-groove effect on IMRT dose distributions
Deng J, Pawlicki T, Chen Y, Li J, Jiang S, Ma C. The MLC tongue-and-groove effect on IMRT dose distributions. Physics In Medicine And Biology 2001, 46: 1039-1060. PMID: 11324950, DOI: 10.1088/0031-9155/46/4/310.Peer-Reviewed Original Research
2000
Validation of a Monte Carlo dose calculation tool for radiotherapy treatment planning
Li JS, Pawlicki T, Deng J, Jiang SB, Mok E, Ma C. Validation of a Monte Carlo dose calculation tool for radiotherapy treatment planning. Physics In Medicine And Biology 2000, 45: 2969-2985. PMID: 11049183, DOI: 10.1088/0031-9155/45/10/316.Peer-Reviewed Original ResearchMonte Carlo verification of IMRT dose distributions from a commercial treatment planning optimization system
Ma C, Pawlicki T, Jiang SB, Li JS, Deng J, Mok E, Kapur A, Xing L, Ma L, Boyer AL. Monte Carlo verification of IMRT dose distributions from a commercial treatment planning optimization system. Physics In Medicine And Biology 2000, 45: 2483-2495. PMID: 11008950, DOI: 10.1088/0031-9155/45/9/303.Peer-Reviewed Original ResearchConceptsMonte Carlo simulationsFinite-size pencil beam (FSPB) algorithmCorvus systemCarlo simulationsOptimization systemIMRT dose distributionsRadiotherapy dose calculationsMonte Carlo treatment planning systemPencil beam algorithmDose distributionMonte CarloBeam algorithmHeterogeneous phantomsMonte Carlo verificationHomogeneous phantomBeam energyCylindrical water phantomIMRT fieldsDose calculationsWater phantomTreatment planning systemField sizeTarget shapeAlgorithmSimulationsEnergy- and intensity-modulated electron beams for radiotherapy
Ma C, Pawlicki T, Lee MC, Jiang SB, Li JS, Deng J, Yi B, Mok E, Boyer AL. Energy- and intensity-modulated electron beams for radiotherapy. Physics In Medicine And Biology 2000, 45: 2293-2311. PMID: 10958195, DOI: 10.1088/0031-9155/45/8/316.Peer-Reviewed Original ResearchConceptsModulated electron radiotherapyIntensity-modulated electron beamElectron beamMultileaf collimatorElectron beam energyInter-leaf leakageDose distributionElectron intraMonte Carlo dose calculationsPencil beam algorithmLeaf endsBeam energyPhoton beamsElectron radiotherapyOblique incidencePatient surfaceMonte Carlo methodBeamBeam algorithmField shapeMonte Carlo simulationsDose calculationsSuperficial targetsCarlo methodCarlo simulations