2022
N 6-methyladenosine enhances post-transcriptional gene regulation by microRNAs
Kanoria S, Rennie WA, Carmack CS, Lu J, Ding Y. N 6-methyladenosine enhances post-transcriptional gene regulation by microRNAs. Bioinformatics Advances 2022, 2: vbab046. PMID: 35098135, PMCID: PMC8792947, DOI: 10.1093/bioadv/vbab046.Peer-Reviewed Original ResearchPost-transcriptional gene regulationMiRNA-binding sitesGene regulationMiRNA-mediated gene regulationEukaryotic messenger RNAsMiRNA-mediated regulationMiRNA-target bindingRNA-binding proteinMiRNA target sitesPost-transcriptional regulatorsPotential methylation sitesHigh GC contentHigh-throughput dataArgonaute proteinsEvolutionary conservationPrevalent modificationTarget mRNAsGC contentMethylation sitesTarget secondary structureGene expressionRNA structureSecondary structureMessenger RNAFunctional significance
2014
Effects of genetic variations on microRNA: target interactions
Liu C, Rennie WA, Carmack CS, Kanoria S, Cheng J, Lu J, Ding Y. Effects of genetic variations on microRNA: target interactions. Nucleic Acids Research 2014, 42: 9543-9552. PMID: 25081214, PMCID: PMC4150780, DOI: 10.1093/nar/gku675.Peer-Reviewed Original ResearchConceptsMiRNA binding sitesGenetic variationGene regulationGenetic variantsMiRNA-mediated gene regulationBinding sitesModulation of miRNAPotential of miRNARare variantsLow mutation frequencyFlanking regionsHuman diseasesVariant densityStructural accessibilityMiRNACommon variantsMutation frequencyMicroRNAsTarget interactionsRegulationStructure alterationsVariantsNew associationsTranscriptomeSites