2014
Cell-Cell Adhesions and Cell Contractility Are Upregulated upon Desmosome Disruption
Sumigray K, Zhou K, Lechler T. Cell-Cell Adhesions and Cell Contractility Are Upregulated upon Desmosome Disruption. PLOS ONE 2014, 9: e101824. PMID: 25006807, PMCID: PMC4090201, DOI: 10.1371/journal.pone.0101824.Peer-Reviewed Original ResearchConceptsAdherens junctionsMyosin IIAAdhesion structuresAnti-Dsg3 antibodiesCell-cell adhesion structuresCell adhesion structuresCell-cell adhesionMyosin II activityDesmosomal protein desmoplakinDesmosome functionTransmembrane componentBarrier functionClaudin genesGenetic disordersSignificant increaseMouse keratinocytesCell contractilityDisruption resultsPosttranslational changesTight junctionsII activity
2012
Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation
Sumigray KD, Foote HP, Lechler T. Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation. Journal Of Cell Biology 2012, 199: 513-525. PMID: 23091070, PMCID: PMC3483132, DOI: 10.1083/jcb.201206143.Peer-Reviewed Original ResearchConceptsReorganization of microtubulesAdherens junctionsNoncentrosomal microtubulesCortical microtubulesCell adhesionCell-cell junctionsMyosin II recruitmentType II myosinMost cell typesDisruption of microtubulesMicrotubule cytoskeletonCell cortexEpidermal cell adhesionMyosin IITight junction functionMyosin IIAEpidermal cellsPhysiological roleBarrier activityCell typesMicrotubulesJunction functionDifferentiating epidermisChemical barrierCell sheets