Human PrimPol: A Novel Mechanism of Antiviral Toxicity
Mislak A, Anderson K. Human PrimPol: A Novel Mechanism of Antiviral Toxicity. The FASEB Journal 2015, 29 DOI: 10.1096/fasebj.29.1_supplement.710.23.Peer-Reviewed Original ResearchNucleoside reverse transcriptase inhibitorsAntiviral toxicityHIV-1HIV-1-infected patientsNRTI-associated mitochondrial toxicityDaily drug regimensHIV-1 infectionLife-long administrationReverse transcriptase inhibitorsReduced viral loadReverse transcriptasePrevent viral transmissionDrug regimensViral loadTranscriptase inhibitorsRelated morbidityInfected patientsSevere mitochondrial dysfunctionSide effectsPatient adherenceViral replicationMechanisms of toxicityMitochondrial toxicityViral transmissionPatients