2021
An Unanticipated Role for Sphingosine Kinase-2 in Bone and in the Anabolic Effect of Parathyroid Hormone
Walker JM, Yao GQ, Siu E, Zhu M, Sun BH, Simpson C, Insogna KL. An Unanticipated Role for Sphingosine Kinase-2 in Bone and in the Anabolic Effect of Parathyroid Hormone. Endocrinology 2021, 162: bqab042. PMID: 33640975, PMCID: PMC8095390, DOI: 10.1210/endocr/bqab042.Peer-Reviewed Original ResearchConceptsSphk2-/- miceParathyroid hormoneAnabolic responseFemoral trabecular BV/TVLower spinal bone mineral densityTrabecular BV/TVSpinal bone mineral densityDaily parathyroid hormoneFemoral bone volumeSuppression of sclerostinEnd of treatmentNormal bone massBone mineral densityNormal bone remodelingRole of SphK1BV/TVFemale control animalsSphingosine kinase 2Sphingosine kinaseControl miceLow BMDAnabolic effectsBone massMineral densityControl animals
1984
Biochemical and Histomorphometric Characterization of a Rat Model for Humoral Hypercalcemia of Malignancy*
INSOGNA K, STEWART A, VIGNERY A, WEIR E, NAMNUM P, BARON R, KIRKWOOD J, DEFTOS L, BROADUS A. Biochemical and Histomorphometric Characterization of a Rat Model for Humoral Hypercalcemia of Malignancy*. Endocrinology 1984, 114: 888-896. PMID: 6546543, DOI: 10.1210/endo-114-3-888.Peer-Reviewed Original ResearchConceptsTumor-bearing animalsBone-resorbing activityHumoral hypercalcemiaDay 13Dihydroxyvitamin D valuesFractional phosphorus excretionQuantitative bone histomorphometryAction of PTHImmunoreactive PTH levelsTumor-bearing groupLeydig cell tumorMale Fisher ratsBone cell functionPTH levelsNephrogenous cAMPDihydroxyvitamin DTumor transplantationCell tumorsBone resorptionBone histomorphometryRat modelTumor groupControl animalsFisher ratsMarked suppression