2013
EBI2 guides osteoclast precursors to bone niches and regulates osteoclastogenesis and bone mass homeostasis. (P5099)
Nevius E, Horowitz M, Insogna K, Ishii M, Pereira J. EBI2 guides osteoclast precursors to bone niches and regulates osteoclastogenesis and bone mass homeostasis. (P5099). The Journal Of Immunology 2013, 190: 129.14-129.14. DOI: 10.4049/jimmunol.190.supp.129.14.Peer-Reviewed Original ResearchOsteoclast precursorsMature osteoclastsBone nicheBone surfaceBone lining cellsEstrogen deficiencyBone marrow nicheBone disordersEBI2Osteoclast differentiationBone mass homeostasisMonocytic precursorsOsteoclastsMarrow nicheBone outgrowthsGuidance cuesSynthesis enzymesHomeostasisDifferentiationCH25HOsteoporosisCYP7B1OsteoclastogenesisMice
2012
LIM kinase 1 deficient mice have reduced bone mass
Kawano T, Zhu M, Troiano N, Horowitz M, Bian J, Gundberg C, Kolodziejczak K, Insogna K. LIM kinase 1 deficient mice have reduced bone mass. Bone 2012, 52: 70-82. PMID: 23017662, PMCID: PMC3688839, DOI: 10.1016/j.bone.2012.09.024.Peer-Reviewed Original ResearchConceptsLIM kinase 1Cytoskeletal remodelingRole of LIMK1Specialized cellular functionsActin cytoskeletal remodelingActin-severing proteinBone cell biologyNormal osteoblast differentiationCellular functionsCell biologyCell motilityCell shapeKinase 1Cell cycleF-actinOsteoblast differentiationPhospho-cofilinActin monomersSkeletal phenotypeOsteoblast coloniesOsteoblastsMetalloproteinase activityDifferentiationRemodelingRate of mineralization