2008
Impact of Glucose‐Dependent Insulinotropic Peptide on Age‐Induced Bone Loss*
Ding K, Shi X, Zhong Q, Kang B, Xie D, Bollag WB, Bollag RJ, Hill W, Washington W, Mi Q, Insogna K, Chutkan N, Hamrick M, Isales CM. Impact of Glucose‐Dependent Insulinotropic Peptide on Age‐Induced Bone Loss*. Journal Of Bone And Mineral Research 2008, 23: 536-543. PMID: 18072880, PMCID: PMC2669161, DOI: 10.1359/jbmr.071202.Peer-Reviewed Original ResearchMeSH KeywordsAgingAnimalsGastric Inhibitory PolypeptideGlucoseMaleMiceMice, Inbred C57BLMice, TransgenicOsteoporosisConceptsGlucose-dependent insulinotropic peptideAge-induced bone lossBone marrow stromal cellsGIP receptor expressionBone lossBone massMo of ageGIP effectsInsulinotropic peptideReceptor expressionEffects of GIPBone strengthOsteoblastic activityAge-associated bone lossElevated GIP levelsFunctional GIP receptorsWildtype control miceBone histomorphometric dataC57BL/6 transgenic miceAge-dependent fashionAge-related decreaseAge-related lossDifferentiation of BMSCsAge-dependent mannerAge-related changes
2007
Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass
Xie D, Zhong Q, Ding KH, Cheng H, Williams S, Correa D, Bollag WB, Bollag RJ, Insogna K, Troiano N, Coady C, Hamrick M, Isales CM. Glucose-dependent insulinotropic peptide-overexpressing transgenic mice have increased bone mass. Bone 2007, 40: 1352-1360. PMID: 17321229, DOI: 10.1016/j.bone.2007.01.007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBody CompositionBone DensityBone ResorptionGastric Inhibitory PolypeptideGene Expression RegulationMiceMice, Inbred C57BLMice, TransgenicOrgan SpecificityReceptors, Gastrointestinal HormoneConceptsGlucose-dependent insulinotropic peptideBone massGIP receptorBone resorptionBone formationNutrient ingestionTransgenic miceGIP receptor knockout miceLow bone mass phenotypeReceptor knockout miceBone mass phenotypeSignificant increaseCollagen type I synthesisGIP levelsInsulinotropic peptideAnabolic hormonesOsteoclastic activityMouse modelDietary zincMass phenotypeKnockout miceReceptor signalingReceptors resultsMiceHormone
2006
Effects of glucose-dependent insulinotropic peptide on osteoclast function
Zhong Q, Itokawa T, Sridhar S, Ding KH, Xie D, Kang B, Bollag WB, Bollag RJ, Hamrick M, Insogna K, Isales CM. Effects of glucose-dependent insulinotropic peptide on osteoclast function. AJP Endocrinology And Metabolism 2006, 292: e543-e548. PMID: 17003233, DOI: 10.1152/ajpendo.00364.2006.Peer-Reviewed Original ResearchConceptsGlucose-dependent insulinotropic peptideBone resorptionNutrient ingestionGIP receptorOrgan culture systemBone breakdownEffects of GIPOsteoclast functionMature osteoclastsGlucose-induced insulin secretionGIP receptor transcriptsImmediate postprandial periodBone formationAnti-resorptive effectsGlucose-dependent insulinotropicIntestinal endocrine cellsOsteoclast resorptive activityPostprandial reductionIncretin hormonesInsulinotropic peptidePostprandial periodInsulin secretionResorptive activityOsteoclastic cellsReceptor transcripts