2024
Emerging and re-emerging themes in co-transcriptional pre-mRNA splicing
Carrocci T, Neugebauer K. Emerging and re-emerging themes in co-transcriptional pre-mRNA splicing. Molecular Cell 2024, 84: 3656-3666. PMID: 39366353, PMCID: PMC11463726, DOI: 10.1016/j.molcel.2024.08.036.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression RegulationHumansRNA Polymerase IIRNA PrecursorsRNA Processing, Post-TranscriptionalRNA SplicingRNA, MessengerSpliceosomesTranscription, GeneticConceptsPre-mRNA splicingCo-transcriptional pre-mRNA splicingCo-transcriptional RNA foldingCo-transcriptional processesRNA polymerase IIPre-messenger RNAFunctional messenger RNAsCapping enzymePolymerase IIDelayed splicingPolyadenylation machinerySplicing eventsPre-mRNAGene regulationMacromolecular machinesRNA foldingRNA synthesisMRNA isoformsProtein productionGene expressionSplicingRNARegulatory importanceCross-regulationMessenger RNA
2018
Dynamics and Function of Nuclear Bodies during Embryogenesis
Escayola D, Neugebauer K. Dynamics and Function of Nuclear Bodies during Embryogenesis. Biochemistry 2018, 57: 2462-2469. PMID: 29473743, DOI: 10.1021/acs.biochem.7b01262.Peer-Reviewed Original ResearchMeSH KeywordsCell NucleolusCoiled BodiesEmbryonic DevelopmentGenomeHistonesHumansNuclear ProteinsRibonucleoproteins, Small NuclearRNARNA Processing, Post-TranscriptionalRNA SplicingTranscription, GeneticConceptsNuclear bodiesCajal bodiesRNA processingZygotic gene productsRNA-protein complexesEfficient RNA processingFunction of nucleoliNuclear body formationGene elementsVariety of organismsZygotic genomeZygotic transitionGenomic lociNascent RNAModel organismsNuclear stepsTranscriptional activationEarly embryosNuclear proteinsGene productsGene locusMembraneless organellesBody formationExcellent modelCell nuclei
1998
Regulation of Alternative Polyadenylation by U1 snRNPs and SRp20
Lou H, Neugebauer K, Gagel R, Berget S. Regulation of Alternative Polyadenylation by U1 snRNPs and SRp20. Molecular And Cellular Biology 1998, 18: 4977-4985. PMID: 9710581, PMCID: PMC109082, DOI: 10.1128/mcb.18.9.4977.Peer-Reviewed Original ResearchAnimalsBase SequenceCalcitoninCalcitonin Gene-Related PeptideConsensus SequenceEnhancer Elements, GeneticExonsHumansMetallothioneinMiceMolecular Sequence DataPoly ARatsRibonucleoprotein, U1 Small NuclearRNA PrecursorsRNA Processing, Post-TranscriptionalRNA-Binding ProteinsSequence AlignmentSequence Homology, Nucleic AcidSerine-Arginine Splicing FactorsThyroid GlandVertebrates
1997
Transcription units as RNA processing units
Neugebauer K, Roth M. Transcription units as RNA processing units. Genes & Development 1997, 11: 3279-3285. PMID: 9407022, DOI: 10.1101/gad.11.24.3279.Peer-Reviewed Original ResearchBinding SitesPhosphorylationRNA Polymerase IIRNA PrecursorsRNA Processing, Post-TranscriptionalRNA SplicingRNA, MessengerTranscription, Genetic