2023
The New NCI Precision Medicine Trials
Harris L, Blanke C, Erba H, Ford J, Gray R, LeBlanc M, Hu-Lieskovan S, Litzow M, Luger S, Meric-Bernstam F, O'Dwyer P, Othus M, Politi K, Shepherd L, Allegra C, Chen H, Ivy S, Korde L, Little R, McShane L, Moscow J, Patton D, Thurin M, Yee L, Doroshow J. The New NCI Precision Medicine Trials. Clinical Cancer Research 2023, 29: of1-of5. PMID: 37531248, PMCID: PMC10690084, DOI: 10.1158/1078-0432.ccr-23-0917.Peer-Reviewed Original ResearchAutologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment
Chiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins K, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze L, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Goedegebuure S, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Kluger Y, Palucka K, Fields R, Flavell R. Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment. Journal For ImmunoTherapy Of Cancer 2023, 11: e006921. PMID: 37487666, PMCID: PMC10373695, DOI: 10.1136/jitc-2023-006921.Peer-Reviewed Original ResearchConceptsHuman tumor microenvironmentTumor microenvironmentTumor-immune interactionsSolid tumorsAdaptive immune activationAdaptive immune populationsIndividual tumor microenvironmentsPatient's hematopoietic systemPatient-derived xenograft tissuesVascular endothelial growth factorBone marrow hematopoietic stemBone marrow aspiratePreclinical drug testingEndothelial growth factorHematopoietic systemAutologous tumorPDX modelingPDX miceImmune activationImmune populationsMarrow aspiratesAutologous systemIndividual patientsLittermate controlsPreclinical predictionsChallenges and opportunities for modeling aging and cancer
Anczuków O, Airhart S, Chuang J, Coussens L, Kuchel G, Korstanje R, Li S, Lucido A, McAllister S, Politi K, Polyak K, Ratliff T, Ren G, Trowbridge J, Ucar D, Palucka K. Challenges and opportunities for modeling aging and cancer. Cancer Cell 2023, 41: 641-645. PMID: 37001528, PMCID: PMC10185379, DOI: 10.1016/j.ccell.2023.03.006.Peer-Reviewed Original Research
2005
Oncogenes Come of Age
VARMUS H, PAO W, POLITI K, PODSYPANINA K, DU Y. Oncogenes Come of Age. Cold Spring Harbor Symposia On Quantitative Biology 2005, 70: 1-9. PMID: 16869733, PMCID: PMC1791364, DOI: 10.1101/sqb.2005.70.039.Chapters