Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor-necrosis-factor-induced apoptosis
Miller-Jensen K, Janes KA, Wong YL, Griffith LG, Lauffenburger DA. Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor-necrosis-factor-induced apoptosis. Journal Of Cell Science 2006, 119: 3788-3798. PMID: 16940353, DOI: 10.1242/jcs.03102.Peer-Reviewed Original ResearchConceptsCellular responsesGrowth factor stimulationAnti-apoptotic signalsFactor-induced apoptosisAnti-apoptotic signalingCell fatePro-survival signalingSubstrate phosphorylationHuman epithelial cellsProtein kinaseCellular survivalAkt activityMK2 activityMolecular biologyAktAdenoviral vectorKinaseApoptosisEpithelial cellsTNF receptorE1/E3-deleted adenoviral vectorsSignalingGrowth factorRecombinant adenovirusClinical gene therapy