1999
Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg2+ Resorption
Simon D, Lu Y, Choate K, Velazquez H, Al-Sabban E, Praga M, Casari G, Bettinelli A, Colussi G, Rodriguez-Soriano J, McCredie D, Milford D, Sanjad S, Lifton R. Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg2+ Resorption. Science 1999, 285: 103-106. PMID: 10390358, DOI: 10.1126/science.285.5424.103.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceCalciumChromosomes, Human, Pair 3ClaudinsCloning, MolecularFemaleGenes, RecessiveHomeostasisHumansKidney DiseasesKidney TubulesLoop of HenleMagnesiumMagnesium DeficiencyMaleMembrane ProteinsMolecular Sequence DataMutationPedigreePhysical Chromosome MappingTight JunctionsConceptsParacellin-1Junction proteinsTight junction proteinsTight junctionsParacellular conductancePositional cloningHuman genesParacellular Mg2Regulated fluxHuman diseasesClaudin familyRenal tight junction proteinBasolateral surfaceProteinRenal Mg2Specific moleculesParacellular fluxParacellular permeabilityEssential componentCellsCloningTranscellular passageGenesConductanceThick ascending limb
1996
Specific Triggering of the Fas Signal Transduction Pathway in Normal Human Keratinocytes*
Freiberg R, Spencer D, Choate K, Peng P, Schreiber S, Crabtree G, Khavari P. Specific Triggering of the Fas Signal Transduction Pathway in Normal Human Keratinocytes*. Journal Of Biological Chemistry 1996, 271: 31666-31669. PMID: 8940187, DOI: 10.1074/jbc.271.49.31666.Peer-Reviewed Original ResearchConceptsFas signal transduction pathwaySignal transduction pathwaysCytoplasmic domainTransduction pathwaysReceptor cytoplasmic domainFas signal transductionSignal transductionConstitutive promoterPlasma membraneGenotoxic injuryHuman keratinocytesFK1012Membrane receptorsCell typesPoint mutationsFA effectsViability of keratinocytesPhorbol esterSpecific triggeringGrowth stimuliFKBPBinding stepCellular changesNormal human keratinocytesProtein