1987
Early Onset (Under Age 30 Years) and Panic Disorder as Markers for Etiologic Homogeneity in Major Depression
Price R, Kidd K, Weissman M. Early Onset (Under Age 30 Years) and Panic Disorder as Markers for Etiologic Homogeneity in Major Depression. JAMA Psychiatry 1987, 44: 434-440. PMID: 3472494, DOI: 10.1001/archpsyc.1987.01800170048008.Peer-Reviewed Original ResearchConceptsEarly onsetMajor depressionPanic disorderLate-onset depressionPrevalence of depressionElevation of riskFamilies of probandsYale Family StudyEtiologic homogeneityHigh riskPatterns of transmissionOlder age cohortsRestriction of analysisDepressionPopulation ratesFamily studiesProbandsOnsetDisordersAge cohortsRiskGenetic modelsSample sizeCohortPrevalence
1986
Understanding the Clinical Heterogeneity of Major Depression Using Family Data
Weissman M, Merikangas K, Priya W, Kidd K, Prusoff B, Leckman J, Pauls D. Understanding the Clinical Heterogeneity of Major Depression Using Family Data. JAMA Psychiatry 1986, 43: 430-434. PMID: 3964021, DOI: 10.1001/archpsyc.1986.01800050028003.Peer-Reviewed Original ResearchConceptsMajor depressionSymptom patternsHistory of hospitalizationClinical presentationClinical severityRecurrent depressionSecondary alcoholismClinical heterogeneitySuicidal ideationAnxiety disordersDepressionFamilial aggregationEarly ageDisordersCombination of criteriaAgeSubgroupsRiskOnsetPutative subgroupsHospitalization
1984
Onset of Major Depression in Early Adulthood: Increased Familial Loading and Specificity
Weissman M, Wickramaratne P, Merikangas K, Leckman J, Prusoff B, Caruso K, Kidd K, Gammon G. Onset of Major Depression in Early Adulthood: Increased Familial Loading and Specificity. JAMA Psychiatry 1984, 41: 1136-1143. PMID: 6508504, DOI: 10.1001/archpsyc.1984.01790230022003.Peer-Reviewed Original ResearchConceptsAge of onsetMajor depressionNormal control subjectsRelatives of probandsFamilial loadingControl subjectsEarly-onset depressionFirst-degree relativesYears of ageHigh familial loadingHigh riskNormal subjectsSpecificity of transmissionEarly adulthoodDepressionProbandsAgeMore studiesFamily studiesYoung personOnsetLater ageHomogeneous disorderSubjectsInverse relationship