On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy
Chen ZJ, Deng J, Roberts K, Nath R. On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy. International Journal Of Radiation Oncology • Biology • Physics 2007, 70: 303-310. PMID: 17980500, PMCID: PMC2289996, DOI: 10.1016/j.ijrobp.2007.09.007.Peer-Reviewed Original ResearchConceptsDose reductionProstate brachytherapyDose compensationLarge edemaBiochemical recurrence-free survivalRecurrence-free survivalSignificant dose reductionEffects of edemaSublethal damage repairAdditional irradiationPrescription doseProstate cancerIndividual patientsEdemaEdema evolutionPrescribed doseProstate edemaEffective doseRadiobiologic effectsBrachytherapyDoseProstate implantsDose responseImplantsTH‐E‐M100E‐07: The Impact of Procedure‐Induced Edema On Cell Survival and Tumor Control Probability in Permanent Prostate Brachytherapy Using 131Cs Radioactive Source
Chen Z, Deng J, Roberts K, Nath R. TH‐E‐M100E‐07: The Impact of Procedure‐Induced Edema On Cell Survival and Tumor Control Probability in Permanent Prostate Brachytherapy Using 131Cs Radioactive Source. Medical Physics 2007, 34: 2655-2655. DOI: 10.1118/1.2761777.Peer-Reviewed Original ResearchTumor control probabilityBiologically effective doseControl probabilityPermanent prostate brachytherapyRadioactive sourcesConcept of biologically effective doseProstate brachytherapyProstate edemaEdema magnitudeProtracted dose deliveryPotential doubling timeRepair half-timeCell survivalDose deliveryEffectiveness of cell killingCell killingTumor potential doubling timeSurviving fraction of cancer cellsEdema-induced increaseInitial tumor burdenFraction of cancer cellsRadiation-induced cell killingHalf-lifeDoubling timeTumor burden