2013
Response
Yu JB, Soulos PR, Herrin J, Cramer LD, Roberts KB, Gross CP. Response. Journal Of The National Cancer Institute 2013, 105: 748-749. PMID: 23814886, DOI: 10.1093/jnci/djt076.Peer-Reviewed Original Research
2012
Proton Versus Intensity-Modulated Radiotherapy for Prostate Cancer: Patterns of Care and Early Toxicity
Yu JB, Soulos PR, Herrin J, Cramer LD, Potosky AL, Roberts KB, Gross CP. Proton Versus Intensity-Modulated Radiotherapy for Prostate Cancer: Patterns of Care and Early Toxicity. Journal Of The National Cancer Institute 2012, 105: 25-32. PMID: 23243199, PMCID: PMC3536640, DOI: 10.1093/jnci/djs463.Peer-Reviewed Original ResearchConceptsIntensity-modulated radiotherapyProstate cancerMedicare beneficiariesGenitourinary toxicityEarly toxicityProton radiotherapyMultivariable logistic regressionPatterns of careMain outcome measuresType of radiotherapyMedicare reimbursementClinical benefitRetrospective studyPRT patientsOutcome measuresComprehensive cohortPRT useIMRT patientsPatientsSociodemographic characteristicsRadiotherapyCancerLogistic regressionMonthsSignificant differences
2011
The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers
Chen Z, Roberts K, Decker R, Pathare P, Rockwell S, Nath R. The impact of prostate edema on cell survival and tumor control after permanent interstitial brachytherapy for early stage prostate cancers. Physics In Medicine And Biology 2011, 56: 4895-4912. PMID: 21772076, PMCID: PMC3154133, DOI: 10.1088/0031-9155/56/15/016.Peer-Reviewed Original ResearchMeSH KeywordsBrachytherapyCell SurvivalEdemaHumansMaleNeoplasm StagingProstateProstatic NeoplasmsRadioisotopesRadiotherapy DosageTreatment OutcomeConceptsPermanent interstitial brachytherapyProstate edemaProstate cancerEffects of edemaTumor control probabilityImpact of edemaInterstitial brachytherapyCell survivalEarly-stage prostate cancerControl probabilityStage prostate cancerCurrent clinical practiceProstate cancer cellsTumor cell proliferationInterstitial brachytherapy treatmentSublethal damage repairDose variationTumor cell survivalTumor characteristicsTumor controlClinical impactEdemaEdema evolutionClinical practiceProstate glandTesticular Doses in Image-Guided Radiotherapy of Prostate Cancer
Deng J, Chen Z, Yu JB, Roberts KB, Peschel RE, Nath R. Testicular Doses in Image-Guided Radiotherapy of Prostate Cancer. International Journal Of Radiation Oncology • Biology • Physics 2011, 82: e39-e47. PMID: 21489702, DOI: 10.1016/j.ijrobp.2011.01.071.Peer-Reviewed Original ResearchConceptsImage-guided radiotherapyTesticular dosesFull-fan modeProstate cancerFemoral headLess doseCBCT scansHalf-fan modeProstate cancer patientsKilovoltage cone-beamCancer patientsIntensity-modulated radiotherapy (IMRT) treatmentKilovoltage CBCTSuperior-inferior directionCone beamDosesCBCT fieldProstate patientsRectumDoseProstateMore doseRadiotherapy treatmentPatientsRadiotherapy
2010
Integrated Prostate Cancer Centers and Over-Utilization of IMRT: A Close Look at Fee-for-Service Medicine in Radiation Oncology
Falit BP, Gross CP, Roberts KB. Integrated Prostate Cancer Centers and Over-Utilization of IMRT: A Close Look at Fee-for-Service Medicine in Radiation Oncology. International Journal Of Radiation Oncology • Biology • Physics 2010, 76: 1285-1288. PMID: 20338470, DOI: 10.1016/j.ijrobp.2009.10.060.Commentaries, Editorials and LettersMeSH KeywordsCancer Care FacilitiesConflict of InterestDisclosureEconomic CompetitionFee-for-Service PlansFees and ChargesHealth ResourcesHumansMaleOwnershipPhysician Self-ReferralProstatic NeoplasmsProvider-Sponsored OrganizationsRadiation OncologyRadiotherapy, Intensity-ModulatedTreatment OutcomeUnited StatesUrology
2007
On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy
Chen ZJ, Deng J, Roberts K, Nath R. On the Need to Compensate for Edema-Induced Dose Reductions in Preplanned 131Cs Prostate Brachytherapy. International Journal Of Radiation Oncology • Biology • Physics 2007, 70: 303-310. PMID: 17980500, PMCID: PMC2289996, DOI: 10.1016/j.ijrobp.2007.09.007.Peer-Reviewed Original ResearchConceptsDose reductionProstate brachytherapyDose compensationLarge edemaBiochemical recurrence-free survivalRecurrence-free survivalSignificant dose reductionEffects of edemaSublethal damage repairAdditional irradiationPrescription doseProstate cancerIndividual patientsEdemaEdema evolutionPrescribed doseProstate edemaEffective doseRadiobiologic effectsBrachytherapyDoseProstate implantsDose responseImplants
2006
Potential impact of prostate edema on the dosimetry of permanent seed implants using the new (model CS‐1) seeds
Chen Z, Deng J, Roberts K, Nath R. Potential impact of prostate edema on the dosimetry of permanent seed implants using the new (model CS‐1) seeds. Medical Physics 2006, 33: 968-975. PMID: 16696473, DOI: 10.1118/1.2179170.Peer-Reviewed Original Research
2000
Dosimetric effects of edema in permanent prostate seed implants: a rigorous solution
Chen Z, Yue N, Wang X, Roberts K, Peschel R, Nath R. Dosimetric effects of edema in permanent prostate seed implants: a rigorous solution. International Journal Of Radiation Oncology • Biology • Physics 2000, 47: 1405-1419. PMID: 10889396, DOI: 10.1016/s0360-3016(00)00549-6.Peer-Reviewed Original Research
1999
Long‐term complications with prostate implants: Iodine‐125 vs. palladium‐103
Peschel R, Chen Z, Roberts K, Nath R. Long‐term complications with prostate implants: Iodine‐125 vs. palladium‐103. International Journal Of Cancer 1999, 7: 278-288. PMID: 10580897, DOI: 10.1002/(sici)1520-6823(1999)7:5<278::aid-roi3>3.0.co;2-3.Peer-Reviewed Original ResearchMeSH KeywordsActuarial AnalysisBrachytherapyCell DeathFollow-Up StudiesForecastingHumansIodine RadioisotopesLongitudinal StudiesMaleModels, BiologicalNeoplasm StagingPalladiumProbabilityProstatic NeoplasmsRadioisotopesRadiopharmaceuticalsRadiotherapy DosageRelative Biological EffectivenessRetrospective StudiesTreatment OutcomeConceptsLong-term complicationsMinimum tumor dosesComplication ratePd-103Lower overall complication ratePalladium-103Long-term complication rateIodine-125Overall complication rateHigh complication rateProstate cancer patientsProstate implantsActuarial probabilityGrade IIILog10 cell killCancer patientsVs. 6Tumor dosesClinical practiceCell killProstate cancer brachytherapyEffective doseNormal tissuesPatientsTissue beds
1998
Correlation of medical dosimetry quality indicators to the local tumor control in patients with prostate cancer treated with iodine‐125 interstitial implants
Nath R, Roberts K, Ng M, Peschel R, Chen Z. Correlation of medical dosimetry quality indicators to the local tumor control in patients with prostate cancer treated with iodine‐125 interstitial implants. Medical Physics 1998, 25: 2293-2307. PMID: 9874821, DOI: 10.1118/1.598440.Peer-Reviewed Original ResearchConceptsSurvival rateProstate cancerInterstitial implantsLocal recurrence-free survival rateRecurrence-free survival ratesLocal control rateLocal tumor controlExcellent clinical resultsProstate cancer patientsUnfavorable groupClinical efficacyCancer patientsControl rateTumor controlClinical resultsFavorable groupDose coveragePatientsDosimetric parametersDosimetry parametersIsodose surfaceSignificant differencesVirginia studyUnfavorable parametersCancer