2024
Adjuvant imatinib in high‐risk resected gastrointestinal stromal tumors: Merely delaying the inevitable?
Sutton T, Billingsley K, Johnson A, Corless C, Blanke C, Heinrich M, Mayo S. Adjuvant imatinib in high‐risk resected gastrointestinal stromal tumors: Merely delaying the inevitable? Journal Of Surgical Oncology 2024, 130: 40-46. PMID: 38924626, DOI: 10.1002/jso.27654.Peer-Reviewed Original ResearchHigh-risk gastrointestinal stromal tumorsRecurrence-free survivalGastrointestinal stromal tumorsResected gastrointestinal stromal tumorsAdjuvant imatinibOverall survivalStromal tumorsAdjuvant therapyDuration of adjuvant imatinibBenefit of adjuvant therapyMonths of postsurgical follow-upMultivariate Cox proportional hazards modelPostsurgical follow-upKaplan-Meier analysisCox proportional hazards modelsProportional hazards modelRadiographic recurrenceImatinib resistanceReviewed patientsFollow-upImatinibOncological treatmentCytocidal effectCancer CenterPatients
2023
Impact of COVID-19 on the gastrointestinal surgical oncology patient population
Bakkila B, Marks V, Kerekes D, Kunstman J, Salem R, Billingsley K, Ahuja N, Laurans M, Olino K, Khan S. Impact of COVID-19 on the gastrointestinal surgical oncology patient population. Heliyon 2023, 9: e18459. PMID: 37534012, PMCID: PMC10391949, DOI: 10.1016/j.heliyon.2023.e18459.Peer-Reviewed Original ResearchGI cancer surgeryPreoperative chemotherapyCancer surgerySurgical careCOVID-19 pandemicCOVID-19Tertiary referral centerOncology patient populationFirst COVID-19 waveGI cancer casesCOVID-19 burdenHigh COVID-19 burdenEmergency surgeryReferral centerCOVID-19 waveOncology visitsGastrointestinal cancerGI cancersPatient populationStudy criteriaCancer careTreatment characteristicsCancer casesCase volumePatients
2021
ASO Visual Abstract: The Disease-Free Interval is Associated with Oncologic Outcomes in Patients with Recurrent Gastrointestinal Stromal Tumor
Sutton T, Walker B, Billingsley K, Sheppard B, Corless C, Heinrich M, Mayo S. ASO Visual Abstract: The Disease-Free Interval is Associated with Oncologic Outcomes in Patients with Recurrent Gastrointestinal Stromal Tumor. Annals Of Surgical Oncology 2021, 28: 426-427. DOI: 10.1245/s10434-021-10107-w.Peer-Reviewed Original Research
2020
Borderline Resectable Pancreatic Cancer Patients Have Superior Survival Following Neoadjuvant Therapy Compared to Upfront Resectable Patients
Deig C, Trone K, Beneville B, Stratton A, Liu A, Kanwar A, Grossblatt-Wait A, Sheppard B, Attia F, Bassale S, Chen Y, Keith D, Chen E, Lopez C, Gilbert E, Billingsley K, Nabavizadeh N, Thomas C, Grossberg A. Borderline Resectable Pancreatic Cancer Patients Have Superior Survival Following Neoadjuvant Therapy Compared to Upfront Resectable Patients. International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e581-e582. DOI: 10.1016/j.ijrobp.2020.07.1786.Peer-Reviewed Original ResearchPandemic Recovery Using a COVID-Minimal Cancer Surgery Pathway
Boffa DJ, Judson BL, Billingsley KG, Galetta D, Fontanez P, Odermatt C, Lindner K, Mitchell MR, Henderson CM, Carafeno T, Pinto J, Wagner J, Ancuta M, Beley P, Turner AL, Banack T, Laurans MS, Johnson DC, Yoo P, Morton JM, Zurich H, Davis K, Ahuja N. Pandemic Recovery Using a COVID-Minimal Cancer Surgery Pathway. The Annals Of Thoracic Surgery 2020, 110: 718-724. PMID: 32417195, PMCID: PMC7227551, DOI: 10.1016/j.athoracsur.2020.05.003.Peer-Reviewed Original ResearchConceptsSurgery pathwayHospital-acquired COVID-19 infectionLarge academic medical centerCOVID-19 patientsCoronavirus disease 2019 (COVID-19) pandemicCOVID-19 infectionPatient care pathwayAcademic medical centerDisease 2019 pandemicHealth care deliveryOnly surgerySurgery populationElective surgeryPatient survivalRisk of exposureProtection of patientsCare pathwayNosocomial infectionsMedical CenterCare deliverySurgical activityHospitalPatientsSurgeryMost hospitalsHepatic arterial infusion pump chemotherapy combined with systemic therapy for patients with advanced colorectal liver metastases: Outcomes in a newly established program
Walker B, Billingsley K, Sutton T, Zarour L, Kolbeck K, Korngold E, Chen E, Kardosh A, Herzig D, Tsikitis V, Nabavizadeh N, Dewey E, Lopez C, Mayo S. Hepatic arterial infusion pump chemotherapy combined with systemic therapy for patients with advanced colorectal liver metastases: Outcomes in a newly established program. Hepato Pancreato Biliary 2020, 22: s123-s124. DOI: 10.1016/j.hpb.2020.04.630.Peer-Reviewed Original Research
2018
Use of circulating cancer cell hybrids to monitor treatment response to hepatic arterial infusion in patients with colorectal cancer metastatic to the liver
Zarour L, Swain J, Billingsley K, Lopez C, Vaccaro G, Nabavizadeh N, Wong M, Mayo S. Use of circulating cancer cell hybrids to monitor treatment response to hepatic arterial infusion in patients with colorectal cancer metastatic to the liver. Hepato Pancreato Biliary 2018, 20: s352. DOI: 10.1016/j.hpb.2018.06.2584.Peer-Reviewed Original Research
2017
Colorectal Cancer Liver Metastasis: Evolving Paradigms and Future Directions
Zarour LR, Anand S, Billingsley KG, Bisson WH, Cercek A, Clarke MF, Coussens LM, Gast CE, Geltzeiler CB, Hansen L, Kelley KA, Lopez CD, Rana SR, Ruhl R, Tsikitis VL, Vaccaro GM, Wong MH, Mayo SC. Colorectal Cancer Liver Metastasis: Evolving Paradigms and Future Directions. Cellular And Molecular Gastroenterology And Hepatology 2017, 3: 163-173. PMID: 28275683, PMCID: PMC5331831, DOI: 10.1016/j.jcmgh.2017.01.006.Peer-Reviewed Original ResearchColorectal cancerHigh-risk patient cohortEarly detectionEffective prognostic indicatorTreatment of patientsTumor immune therapyNew therapeutic regimensColorectal tumor biologyCurative resectionIntrahepatic recurrenceRecurrent diseaseSystemic therapyTreatment toxicityLiver metastasesImmune therapyTreatment regimensPrognostic indicatorTherapeutic regimensCancer carePatient cohortMetastatic spreadTreatment responseHigh riskPrognostic studiesPatients
2015
Malignancy does not dictate the hypercoagulable state following liver resection
Gordon N, Riha G, Billingsley K, Schreiber M. Malignancy does not dictate the hypercoagulable state following liver resection. The American Journal Of Surgery 2015, 209: 870-874. PMID: 25805455, DOI: 10.1016/j.amjsurg.2014.12.022.Peer-Reviewed Original ResearchConceptsRelative hypercoagulable stateLiver resectionHypercoagulable stateMalignant diseaseTEG valuesMalignancy statusCause of hypercoagulabilityPostoperative coagulopathyCoagulation profileRetrospective reviewResectionNormal rangePatientsDiseaseSignificant differencesMalignancyMedian valueR timeStatusCoagulopathyHypercoagulabilityGroup
2014
The international normalized ratio overestimates coagulopathy in patients after major hepatectomy
Louis S, Barton J, Riha G, Orloff S, Sheppard B, Pommier R, Underwood S, Differding J, Schreiber M, Billingsley K. The international normalized ratio overestimates coagulopathy in patients after major hepatectomy. The American Journal Of Surgery 2014, 207: 723-727. PMID: 24791634, DOI: 10.1016/j.amjsurg.2013.12.021.Peer-Reviewed Original ResearchConceptsInternational normalized ratioMajor hepatectomyNormalized ratioPatient populationElevated international normalized ratioUse of thrombelastographyPostoperative day 1Postoperative time pointsHypercoagulable statePreoperative valuesDecreased incidenceProcoagulant factorsTEG measurementsCoagulation factorsDay 1ThrombelastographyHepatectomyFactor VIIISubsequent normalizationPatientsTime pointsHypocoagulabilityTherapyProtein C.
2011
Predicting malignant intraductal papillary mucinous neoplasm: a single-center review
Cone M, Rea J, Diggs B, Douthit M, Billingsley K, Sheppard B. Predicting malignant intraductal papillary mucinous neoplasm: a single-center review. The American Journal Of Surgery 2011, 201: 575-579. PMID: 21545902, DOI: 10.1016/j.amjsurg.2011.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, MucinousAdultAgedAged, 80 and overCarcinoma, Pancreatic DuctalCarcinoma, PapillaryDiagnosis, DifferentialEndosonographyFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedPancreatectomyPancreatic NeoplasmsPrognosisRetrospective StudiesSurvival RateTime FactorsTomography, X-Ray ComputedUnited StatesConceptsIntraductal papillary mucinous neoplasmInternational consensus guidelinesMalignant intraductal papillary mucinous neoplasmPapillary mucinous neoplasmConsensus guidelinesMucinous neoplasmsInvasive cancerMain duct intraductal papillary mucinous neoplasmPancreatic intraductal papillary mucinous neoplasmsPercent of patientsSingle-center reviewHigh-grade dysplasiaMayo criteriaWorse survivalPatient groupFemale sexSingle institutionMayo ClinicLower riskPatientsMultivariate analysisCancerResectionMain ductNeoplasmsSafety and Efficacy of Preoperative Portal Vein Embolization in Patients at Risk for Postoperative Liver Failure
Massimino K, Kolbeck K, Enestvedt C, Orloff S, Billingsley K. Safety and Efficacy of Preoperative Portal Vein Embolization in Patients at Risk for Postoperative Liver Failure. Gastroenterology 2011, 140: s-1018. DOI: 10.1016/s0016-5085(11)64230-3.Peer-Reviewed Original Research
2010
Endoscopic ultrasound may be unnecessary in the preoperative evaluation of intraductal papillary mucinous neoplasm
Cone M, Rea J, Diggs B, Billingsley K, Sheppard B. Endoscopic ultrasound may be unnecessary in the preoperative evaluation of intraductal papillary mucinous neoplasm. Hepato Pancreato Biliary 2010, 13: 112-116. PMID: 21241428, PMCID: PMC3044345, DOI: 10.1111/j.1477-2574.2010.00254.x.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiopsy, Fine-NeedleCarcinoma, Pancreatic DuctalCarcinoma, PapillaryChi-Square DistributionEndosonographyFemaleHumansLogistic ModelsMaleNeoplasms, Cystic, Mucinous, and SerousOdds RatioOregonPancreatic NeoplasmsPredictive Value of TestsPreoperative CareRetrospective StudiesTomography, X-Ray ComputedUnnecessary ProceduresConceptsIntraductal papillary mucinous neoplasmHigh-grade dysplasiaFine needle aspiratesPapillary mucinous neoplasmEndoscopic ultrasoundComputed tomographyCT scanMucinous neoplasmsCarcinoembryonic antigenPancreatic intraductal papillary mucinous neoplasmsDuct diameterLesion diameterPancreatic duct diameterPreoperative computed tomographyHigh-resolution CT scanningPreoperative evaluationInvasive cancerMedical recordsRadiographic criteriaStudy groupPatientsLesion sizeNeedle aspiratesMultivariate analysisCT scanning
2008
Response: Re: Residual Treatment Disparities After Oncology Referral for Rectal Cancer
Morris A, Billingsley K, Hayanga A, Matthews B, Baldwin L, Birkmeyer J. Response: Re: Residual Treatment Disparities After Oncology Referral for Rectal Cancer. Journal Of The National Cancer Institute 2008, 100: 1740-1740. PMID: 18477800, PMCID: PMC2766763, DOI: 10.1093/jnci/djn396.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBlack or African AmericanChemotherapy, AdjuvantConfidence IntervalsDecision MakingFemaleHealth Services AccessibilityHealthcare DisparitiesHumansLogistic ModelsMaleMedical OncologyMedical Record LinkageMedicareNeoplasm StagingPractice Patterns, Physicians'Radiation OncologyRadiotherapy, AdjuvantRectal NeoplasmsReferral and ConsultationSEER ProgramUnited StatesWhite PeopleConceptsRectal cancerAdjuvant therapyBlack patientsWhite patientsRadiation oncologistsAdjuvant treatmentMedical oncologistsEnd Results-Medicare dataProvider decision makingPatient-provider interactionsFrequency of consultationsLow treatment ratesClinical characteristicsElderly patientsConsultation ratesOncology referralTreatment disparitiesPatient preferencesProvider characteristicsRadiation therapyPatientsOncologistsTherapyStage IITreatment ratesDiagnostic Laparoscopy for Patients with Potentially Resectable Pancreatic Adenocarcinoma: Is It Cost-Effective in the Current Era?
Enestvedt C, Mayo S, Diggs B, Mori M, Austin D, Shipley D, Sheppard B, Billingsley K. Diagnostic Laparoscopy for Patients with Potentially Resectable Pancreatic Adenocarcinoma: Is It Cost-Effective in the Current Era? Journal Of Gastrointestinal Surgery 2008, 12: 1177-1184. PMID: 18470572, DOI: 10.1007/s11605-008-0514-y.Peer-Reviewed Original ResearchConceptsDiagnostic laparoscopyPancreatic cancerPancreatic adenocarcinomaUtilization of laparoscopyResectable pancreatic cancerResectable pancreatic adenocarcinomaPancreatic cancer databaseUse of laparoscopyState Cancer RegistryMedical record dataBiliary bypassPreoperative laparoscopyResectable patientsUnderwent laparoscopyUnresectable diseaseLaparoscopic explorationPeritoneal metastasisCancer RegistryStaging modalitiesCancer DatabaseAverage hospitalLaparoscopyMedicare dataPhysician chargesPatients
2006
Complications and Antireflux Medication Use After Antireflux Surgery
Dominitz J, Dire C, Billingsley K, Todd–Stenberg J. Complications and Antireflux Medication Use After Antireflux Surgery. Clinical Gastroenterology And Hepatology 2006, 4: 299-305. PMID: 16527692, DOI: 10.1016/j.cgh.2005.12.019.Peer-Reviewed Original ResearchConceptsAntireflux medication useAntireflux surgeryMedication useAntireflux medicationVeterans Affairs administrative databasesPredictors of complicationsGastroesophageal reflux diseaseMore outpatient visitsSurgical mortality rateHealth care useH2-receptor antagonistsPostoperative complicationsPromotility agentsReflux diseasePharmacy recordsOutpatient visitsEsophageal cancerReceptor antagonistCare useAdministrative databasesMultiple prescriptionsComplicationsPatientsMortality rateSurgeryCurrent Status of Colorectal Cancer Therapy
Strother J, Billingsley K, Hung A, Blanke C. Current Status of Colorectal Cancer Therapy. 2006, 273-285. DOI: 10.1007/978-1-59745-172-7_23.Peer-Reviewed Original Research
2005
Clinical utility and cost-effectiveness of routine preoperative computed tomography scanning in patients with colon cancer
Mauchley D, Lynge D, Langdale L, Stelzner M, Mock C, Billingsley K. Clinical utility and cost-effectiveness of routine preoperative computed tomography scanning in patients with colon cancer. The American Journal Of Surgery 2005, 189: 512-517. PMID: 15862487, DOI: 10.1016/j.amjsurg.2005.01.027.Peer-Reviewed Original ResearchConceptsPreoperative CT scanningRoutine preoperative CT scanningColon cancer patientsCT scanningCancer patientsCT scanClinical utilityPreoperative computed tomography scanningMode of treatmentComputed tomography scanningNontherapeutic operationsConsecutive patientsClinical managementAlters treatmentPatientsColon cancerTomography scanningTreatment planningInstitutional costsScansTreatmentCost savingsCancer
2002
The utility of routine preoperative computed tomography scanning in the management of veterans with colon cancer
Barton J, Langdale L, Cummins J, Stelzner M, Lynge D, Mock C, Nason K, Billingsley K. The utility of routine preoperative computed tomography scanning in the management of veterans with colon cancer. The American Journal Of Surgery 2002, 183: 499-503. PMID: 12034380, DOI: 10.1016/s0002-9610(02)00841-3.Peer-Reviewed Original ResearchConceptsPreoperative computed tomography scanningComputed tomography scanningColon cancerClinical managementPreoperative CTRoutine preoperative CT scanningTomography scanningCT scanningRoutine preoperative studiesPreoperative CT scanningPreoperative CT scanManagement of veteransIntraperitoneal colonPreoperative studiesMedical recordsOperative notesCT scanClinical utilityPatientsPreoperative scansCancerAdditional studiesHealthcare systemTreatment planningCTThe Development of a Telemedical Cancer Center within the Veterans Affairs Health Care System: A Report of Preliminary Clinical Results
Billingsley K, Schwartz D, Lentz S, Vallires E, Montgomery R, Schubach W, Penson D, Yueh B, Chansky H, Zink C, Parayno D, Starkebaum G. The Development of a Telemedical Cancer Center within the Veterans Affairs Health Care System: A Report of Preliminary Clinical Results. Telemedicine Journal And E-Health 2002, 8: 123-130. PMID: 12020412, DOI: 10.1089/15305620252933464.Peer-Reviewed Original ResearchConceptsVeterans Affairs Health Care SystemMultidisciplinary cancer careRegional Cancer CentreCancer CenterPreliminary clinical resultsTumor boardClinical resultsHealth care systemCancer careVeterans Integrated Service Network 20Outlying facilitiesCare systemAdditional diagnostic studiesEntire clinical spectrumEarly clinical resultsMultidisciplinary consultationTreatment delayClinical spectrumMalignant diseaseClinical detailsReferral processPatient travelPatient diagnosisTelemedicine linkPatients