2017
Interleukin-8 in cancer pathogenesis, treatment and follow-up
Alfaro C, Sanmamed MF, Rodríguez-Ruiz ME, Teijeira Á, Oñate C, González Á, Ponz M, Schalper KA, Pérez-Gracia JL, Melero I. Interleukin-8 in cancer pathogenesis, treatment and follow-up. Cancer Treatment Reviews 2017, 60: 24-31. PMID: 28866366, DOI: 10.1016/j.ctrv.2017.08.004.Peer-Reviewed Original ResearchConceptsSerum concentrationsInterleukin-8IL-8 serum concentrationsPro-tumoral functionsCancer stem cellsTumor burdenLeukocyte infiltrateCancer immunotherapyIL-8Pharmacodynamic biomarkersTherapeutic combinationsTherapeutic strategiesMyeloid cellsTumor progressionCancer pathogenesisTumor cellsGrowth factorImmunotherapySuch interventionsChemokinesStem cellsCellsInfiltratesCXCR1/2Pathogenesis
2014
Possible role of hemichannels in cancer
Schalper KA, Carvajal-Hausdorf D, Oyarzo MP. Possible role of hemichannels in cancer. Frontiers In Physiology 2014, 5: 237. PMID: 25018732, PMCID: PMC4073485, DOI: 10.3389/fphys.2014.00237.Peer-Reviewed Original ResearchDiverse cell processesPost-translational eventsCell proliferationPossible roleTumor suppressorMembrane transportInvolvement of hemichannelsHemichannelsCell processesCancer cellsCurrent technical limitationsTumor progressionTumor growthProliferationCellsPannexinsNeoplastic cellsSuppressorPanxsRoleConnexinsImmune responseProteinTechnical limitations
2008
Connexin Hemichannel Composition Determines the FGF-1–induced Membrane Permeability and Free [Ca2+]i Responses
Schalper K, Palacios-Prado N, Retamal M, Shoji K, Martínez A, Sáez J. Connexin Hemichannel Composition Determines the FGF-1–induced Membrane Permeability and Free [Ca2+]i Responses. Molecular Biology Of The Cell 2008, 19: 3501-3513. PMID: 18495870, PMCID: PMC2488314, DOI: 10.1091/mbc.e07-12-1240.Peer-Reviewed Original ResearchConceptsHeLa cellsC-terminusP38 MAP kinase-dependent pathwayMembrane permeabilityMAP kinase-dependent pathwayDifferent connexin typesKinase-dependent pathwayFGF-1HeLa transfectantsDiverse cellsRegulatory sitesCellular responsesCell surfaceCell permeabilizationHemichannelsConnexin typesSerum-free mediumCx26CellsPossible roleCell densityCx43Early intracellularPermeabilizationTransfectantsCurrently Used Methods for Identification and Characterization of Hemichannels
Schalper K, Palacios-Prado N, Orellana J, Sáez J. Currently Used Methods for Identification and Characterization of Hemichannels. Cell Communication & Adhesion 2008, 15: 207-218. PMID: 18649191, DOI: 10.1080/15419060802014198.Peer-Reviewed Original ResearchConceptsVertebrate cellsMammalian cellsTransmembrane proteinPlasma membraneFunctional hemichannelsMolecular identityPannexin hemichannelsConnexin hemichannelsHemichannelsCommunication pathwaysSmall moleculesConnexinsNew experimental approachExperimental approachCellsPannexinsBulk of informationProteinIdentificationPathwayParacrineMembraneVivoResponseFurther studies