2014
Possible role of hemichannels in cancer
Schalper KA, Carvajal-Hausdorf D, Oyarzo MP. Possible role of hemichannels in cancer. Frontiers In Physiology 2014, 5: 237. PMID: 25018732, PMCID: PMC4073485, DOI: 10.3389/fphys.2014.00237.Peer-Reviewed Original ResearchDiverse cell processesPost-translational eventsCell proliferationPossible roleTumor suppressorMembrane transportInvolvement of hemichannelsHemichannelsCell processesCancer cellsCurrent technical limitationsTumor progressionTumor growthProliferationCellsPannexinsNeoplastic cellsSuppressorPanxsRoleConnexinsImmune responseProteinTechnical limitations
2013
Role of Gap Junctions and Hemichannels in Parasitic Infections
Vega JL, Subiabre M, Figueroa F, Schalper KA, Osorio L, González J, Sáez JC. Role of Gap Junctions and Hemichannels in Parasitic Infections. BioMed Research International 2013, 2013: 589130. PMID: 24236292, PMCID: PMC3819887, DOI: 10.1155/2013/589130.Peer-Reviewed Original ResearchConceptsForm gap junction channelsCell-cell interfaceDiverse physiologic processesGap junction channelsInvertebrate cellsVertebratesJunction channelsRole of CxsCell surfaceNew therapeutic designsPanx channelsHemichannelsGap junctionsTherapeutic designCellular communicationRecent findingsParasitic infectionsPhysiologic processesPathological statesPossible roleCxRecent evidenceInnexinsChannel typesPannexins
2012
Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels
Orellana J, Sánchez H, Schalper K, Figueroa V, Sáez J. Regulation of Intercellular Calcium Signaling Through Calcium Interactions with Connexin-Based Channels. Advances In Experimental Medicine And Biology 2012, 740: 777-794. PMID: 22453969, DOI: 10.1007/978-94-007-2888-2_34.Peer-Reviewed Original ResearchConceptsGap junction channelsConnexin-based channelsExtra-cellular milieuNumerous cellular eventsCell-cell interactionsMembrane proteinsMolecular basisCellular eventsIntercellular communicationJunction channelsRole of Ca2ConnexinsIntercellular calciumHemichannelsIntercellular propagationIntercellular Ca2RegulationCalcium wavesCalcium interactionCa2ProteinPathwayInteractionFamily
2010
Cell membrane permeabilization via connexin hemichannels in living and dying cells
Sáez J, Schalper K, Retamal M, Orellana J, Shoji K, Bennett M. Cell membrane permeabilization via connexin hemichannels in living and dying cells. Experimental Cell Research 2010, 316: 2377-2389. PMID: 20595004, DOI: 10.1016/j.yexcr.2010.05.026.Peer-Reviewed Original ResearchConceptsCell membrane permeabilityMembrane permeabilityComplex signaling cascadesConnexin hemichannelsDiverse cell typesCx HCsGap junction channelsVertebrate cellsCell membrane permeabilizationForm hemichannelsMembrane permeabilizationSignaling cascadesOpen probabilityJunction channelsCell typesCultured cellsExtracellular microenvironmentCell membraneHemichannelsMost cellsLow open probabilityStage dependencyUnitary conductanceSmall moleculesConnexins
2009
Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases.
Schalper K, Orellana J, Berthoud V, Sáez J. Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases. Current Vascular Pharmacology 2009, 7: 486-505. PMID: 19485891, DOI: 10.2174/157016109789043937.Peer-Reviewed Original ResearchConceptsHuman genetic diseasesNormal cell functioningHemichannel activityMost cell typesConnexin mutantsForm homoTransmembrane proteinMembrane permeabilizationPlasma membraneLethal stimuliMembrane pathwaysCell functioningHuman diseasesCell deathCell typesGenetic diseasesMost cellsHemichannelsPannexinsSmall moleculesConnexinsTransportersPathological conditionsPathwayVertebratesModulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration
Orellana JA, Sáez PJ, Shoji KF, Schalper KA, Palacios–Prado N, Velarde V, Giaume C, Bennett MV, Sáez JC. Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration. Antioxidants & Redox Signaling 2009, 11: 369-399. PMID: 18816186, PMCID: PMC2713807, DOI: 10.1089/ars.2008.2130.Peer-Reviewed Original ResearchConceptsGap junction channelsJunction channelsDiverse cell typesPro-inflammatory agentsAcute inflammatory responseActivity of hemichannelsGap junctional communicationGlial hemichannelsProtein subunitsCx43 hemichannel activityGlial activationAnomalous proteinInflammatory processMembrane channelsCell typesNeuronal viabilityInflammatory responseNeuronal Cx36Astroglial networksNormal brainHemichannel activityChannel disordersHemichannelsSubthreshold stimulationATP release
2008
Connexin Hemichannel Composition Determines the FGF-1–induced Membrane Permeability and Free [Ca2+]i Responses
Schalper K, Palacios-Prado N, Retamal M, Shoji K, Martínez A, Sáez J. Connexin Hemichannel Composition Determines the FGF-1–induced Membrane Permeability and Free [Ca2+]i Responses. Molecular Biology Of The Cell 2008, 19: 3501-3513. PMID: 18495870, PMCID: PMC2488314, DOI: 10.1091/mbc.e07-12-1240.Peer-Reviewed Original ResearchConceptsHeLa cellsC-terminusP38 MAP kinase-dependent pathwayMembrane permeabilityMAP kinase-dependent pathwayDifferent connexin typesKinase-dependent pathwayFGF-1HeLa transfectantsDiverse cellsRegulatory sitesCellular responsesCell surfaceCell permeabilizationHemichannelsConnexin typesSerum-free mediumCx26CellsPossible roleCell densityCx43Early intracellularPermeabilizationTransfectantsCurrently Used Methods for Identification and Characterization of Hemichannels
Schalper K, Palacios-Prado N, Orellana J, Sáez J. Currently Used Methods for Identification and Characterization of Hemichannels. Cell Communication & Adhesion 2008, 15: 207-218. PMID: 18649191, DOI: 10.1080/15419060802014198.Peer-Reviewed Original ResearchConceptsVertebrate cellsMammalian cellsTransmembrane proteinPlasma membraneFunctional hemichannelsMolecular identityPannexin hemichannelsConnexin hemichannelsHemichannelsCommunication pathwaysSmall moleculesConnexinsNew experimental approachExperimental approachCellsPannexinsBulk of informationProteinIdentificationPathwayParacrineMembraneVivoResponseFurther studies