2019
Improved Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Forceps Biopsies: A Retrospective Analysis
Ray AS, Li C, Murphy TE, Cai G, Araujo KLB, Bramley K, DeBiasi EM, Pisani MA, Cortopassi IO, Puchalski JT. Improved Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Forceps Biopsies: A Retrospective Analysis. The Annals Of Thoracic Surgery 2019, 109: 894-901. PMID: 31593653, PMCID: PMC9376016, DOI: 10.1016/j.athoracsur.2019.08.106.Peer-Reviewed Original ResearchConceptsStandard of careTransbronchial needle aspirationDiagnostic yieldHilar lymphadenopathyEndobronchial ultrasound transbronchial needle aspirationMediastinal/hilar lymphadenopathySolid organ malignanciesHigh diagnostic yieldGood tissue qualitySpecimen qualityForceps biopsyEBUS-TBNAParenchymal findingsPreprocedural imagingEndobronchial ultrasoundNeedle aspirationRetrospective analysisLymphadenopathyDiagnostic criteriaPatient basisDisease processTissue acquisitionPatientsClinical scenariosSarcoidosisSafety and Tolerability of Vacuum Versus Manual Drainage During Thoracentesis
Senitko M, Ray AS, Murphy TE, Araujo KLB, Bramley K, DeBiasi EM, Pisani MA, Cameron K, Puchalski JT. Safety and Tolerability of Vacuum Versus Manual Drainage During Thoracentesis. Journal Of Bronchology & Interventional Pulmonology 2019, 26: 166-171. PMID: 30433893, PMCID: PMC6517094, DOI: 10.1097/lbr.0000000000000556.Peer-Reviewed Original ResearchConceptsCause complicationsVacuum groupGreater painSelf-reported painAcademic medical centerShorter drainage timeManual drainageEarly terminationPain scoresRefractory symptomsRespiratory failurePain levelsSecondary outcomesPatient characteristicsPrimary outcomePleural effusionPleural manometryPulmonary edemaVacuum aspirationManual aspirationMedical CenterPatient comfortThoracentesisSubsequent deathDrainage time
2017
Indications for invasive mediastinal staging in patients with early non-small cell lung cancer staged with PET-CT
Gao SJ, Kim AW, Puchalski JT, Bramley K, Detterbeck FC, Boffa DJ, Decker RH. Indications for invasive mediastinal staging in patients with early non-small cell lung cancer staged with PET-CT. Lung Cancer 2017, 109: 36-41. PMID: 28577947, DOI: 10.1016/j.lungcan.2017.04.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungClinical Decision-MakingDiagnostic ImagingFemaleHumansLung NeoplasmsMaleMediastinumMiddle AgedNeoplasm MetastasisNeoplasm StagingPatient SelectionPositron Emission Tomography Computed TomographyPractice Guidelines as TopicRetrospective StudiesConceptsOccult N2 diseaseOccult N2 metastasesGround-glass componentInvasive mediastinal stagingCurative-intent therapyT2 tumorsN2 metastasisPET-CTInvasive stagingN2 diseaseT1 tumorsNegative predictive valueMediastinal stagingEarly non-small cell lung cancerExact testPredictive valueSolid tumorsNon-small cell lung cancerClinical stage I NSCLCN2 lymph nodesNode-negative NSCLCOccult nodal involvementPure-solid tumorsStage I NSCLCT1-2N0 disease
2016
Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration
Bramley K, Pisani MA, Murphy TE, Araujo KL, Homer RJ, Puchalski JT. Endobronchial Ultrasound-Guided Cautery-Assisted Transbronchial Forceps Biopsies: Safety and Sensitivity Relative to Transbronchial Needle Aspiration. The Annals Of Thoracic Surgery 2016, 101: 1870-1876. PMID: 26912301, PMCID: PMC4861078, DOI: 10.1016/j.athoracsur.2015.11.051.Peer-Reviewed Original ResearchConceptsTransbronchial needle aspirationTransbronchial forceps biopsyForceps biopsyClinical trialsEndobronchial ultrasoundNeedle aspirationConvex probe EBUSSignificant adverse eventsDiagnosis of sarcoidosisExcellent diagnostic yieldSelect clinical scenariosSequential useTBNA samplesSecondary outcomesUnselected patientsAdverse eventsLymph nodesThoracic lymphadenopathyEBUS guidanceGranulomatous inflammationCore biopsyGranulomatous diseaseAdequate specimensNeedle biopsyDiagnostic yield
2013
Patterns of Opiate, Benzodiazepine, and Antipsychotic Drug Dosing in Older Patients in a Medical Intensive Care Unit
Pisani MA, Bramley K, Vest MT, Akgün KM, Araujo KL, Murphy TE. Patterns of Opiate, Benzodiazepine, and Antipsychotic Drug Dosing in Older Patients in a Medical Intensive Care Unit. American Journal Of Critical Care 2013, 22: e62-e69. PMID: 23996429, PMCID: PMC4309662, DOI: 10.4037/ajcc2013835.Peer-Reviewed Original ResearchConceptsMedical intensive care unitIntensive care unitOlder patientsCare unitNursing shiftsHigh dosesEvening shiftsNight shiftsYale-New Haven HospitalEvening nursing shiftsPatients 60 yearsRoute of administrationImportant clinical covariatesMean ageClinical covariatesPsychoactive medicationsDrug dosingRandom effects Poisson modelDose levelsPatientsHaloperidolTotal dosesLorazepamSleep deprivationFentanyl