Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1β
Pradhan A, Maji S, Bhoopathi P, Talukdar S, Mannangatti P, Guo C, Wang X, Cartagena L, Idowu M, Landry J, Sarkar D, Emdad L, Cavenee W, Das S, Fisher P. Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1β. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2103180118. PMID: 34016751, PMCID: PMC8166168, DOI: 10.1073/pnas.2103180118.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBreast NeoplasmsCell Line, TumorChemokine CCL11Chemokine CCL17FemaleGene Expression Regulation, NeoplasticHumansInterleukin-10Interleukin-1alphaInterleukin-1betaInterleukin-23 Subunit p19Interleukin-5Lung NeoplasmsMiceMice, Inbred BALB COxadiazolesPyrimidinesSignal TransductionSynteninsT-Lymphocytes, CytotoxicTumor BurdenXenograft Model Antitumor AssaysConceptsMDA-9/SynteninMyeloid-derived suppressor cell differentiationSuppressor cell differentiationCancer cellsAdvanced disease stageAggressive breast cancerCytotoxic T lymphocytesMetastatic nodule formationBreast cancer metastasisBreast cancer pathogenesisMda-9/syntenin expressionCancer cell metastasisDirect therapeutic targetsCancer cell linesDiverse cancer cell linesPatient survivalDisease stageIL-1βSyndecan binding proteinBreast cancerInvasive cancer cellsT lymphocytesTherapeutic targetSmall molecule inhibitorsAdvanced stage