2017
Functional germline variants as potential co-oncogenes
Agarwal D, Nowak C, Zhang NR, Pusztai L, Hatzis C. Functional germline variants as potential co-oncogenes. Npj Breast Cancer 2017, 3: 46. PMID: 29177190, PMCID: PMC5700137, DOI: 10.1038/s41523-017-0051-5.Peer-Reviewed Original ResearchRecent genome sequencing studiesFunction of proteinsDifferent oncogenic eventsGermline variantsGenome sequencing studiesSomatic mutationsDriver mutationsPhenotypic variationSpecific cancer subtypesLarge breast cancer cohortSomatic driver mutationsSequencing studiesFull malignant transformationFunctional germline variantsCancer biologyRecurrent driver mutationsOncogenic eventsSomatic eventsMutationsGermline aberrationsGermline polymorphismsFamilial cancerIndividual cancersMalignant transformationPolymorphism
2014
Combined analysis of gene expression, DNA copy number, and mutation profiling data to display biological process anomalies in individual breast cancers
Shi W, Balazs B, Györffy B, Jiang T, Symmans WF, Hatzis C, Pusztai L. Combined analysis of gene expression, DNA copy number, and mutation profiling data to display biological process anomalies in individual breast cancers. Breast Cancer Research And Treatment 2014, 144: 561-568. PMID: 24619174, DOI: 10.1007/s10549-014-2904-z.Peer-Reviewed Original ResearchConceptsDNA copy numberBiological processesIndividual molecular eventsCopy numberGene expressionMolecular eventsMulticellular organismal processGene Ontology databaseGO biological processesSignal transduction pathwaysOrganismal processesGO termsMolecular dataTransduction pathwaysSiRNA screenComplex genomic abnormalitiesIndividual cancersOntology databaseFunctional roleDriver eventsCell growthSequence abnormalitiesBreast cancer cell linesCancer cell linesGenomic abnormalities