2011
Gene expression profiling in breast cancer: classification, prognostication, and prediction
Reis-Filho JS, Pusztai L. Gene expression profiling in breast cancer: classification, prognostication, and prediction. The Lancet 2011, 378: 1812-1823. PMID: 22098854, DOI: 10.1016/s0140-6736(11)61539-0.Peer-Reviewed Original ResearchConceptsBreast cancerER-negative breast cancerGene expression profilingER-positive diseasePrognosis of patientsDistinct molecular aberrationsMolecular classification systemPotential clinical useClinical behaviorHistological featuresClinical trialsMolecular subtypesProliferation-related genesMultigene classifiersClinical practiceMolecular aberrationsExpression profilingCancerDistinct diseasesMultigene predictorsClinical useMolecular classificationDiseaseHeterogeneous groupDifferent diseases
2006
Molecular classification of breast cancer: implications for selection of adjuvant chemotherapy
Andre F, Pusztai L. Molecular classification of breast cancer: implications for selection of adjuvant chemotherapy. Nature Reviews Clinical Oncology 2006, 3: 621-632. PMID: 17080180, DOI: 10.1038/ncponc0636.Peer-Reviewed Original ResearchConceptsAdjuvant chemotherapyMolecular classificationBreast cancerER-positive tumorsEarly-stage diseaseNew molecular classificationRoutine clinical useAdjuvant therapyNegative diseaseEstrogen receptorIndividual patientsChemotherapyClinical usePatientsCancerDiseaseMolecular characteristicsFuture promiseTherapyTumorsReceptorsMolecular Classification of Breast Cancer: Limitations and Potential
Pusztai L, Mazouni C, Anderson K, Wu Y, Symmans WF. Molecular Classification of Breast Cancer: Limitations and Potential. The Oncologist 2006, 11: 868-877. PMID: 16951390, DOI: 10.1634/theoncologist.11-8-868.Peer-Reviewed Original ResearchConceptsBreast cancerMolecular classificationNovel risk stratification methodsEstrogen receptor immunohistochemistryBreast cancer patientsRisk stratification methodsRoutine diagnostic workupTranscription-polymerase chain reactionNew molecular classificationReceptor immunohistochemistryCancer patientsDiagnostic workupPolymerase chain reactionBest therapyMolecular subsetsPredictive valueClinical researchCancerDiagnostic testsPredictive testChain reactionMedical decisions
2005
Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy
Rouzier R, Perou CM, Symmans WF, Ibrahim N, Cristofanilli M, Anderson K, Hess KR, Stec J, Ayers M, Wagner P, Morandi P, Fan C, Rabiul I, Ross JS, Hortobagyi GN, Pusztai L. Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy. Clinical Cancer Research 2005, 11: 5678-5685. PMID: 16115903, DOI: 10.1158/1078-0432.ccr-04-2421.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntineoplastic Combined Chemotherapy ProtocolsBiopsy, NeedleBreastBreast NeoplasmsCluster AnalysisDoxorubicinFemaleFluorouracilGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMiddle AgedMultivariate AnalysisOligonucleotide Array Sequence AnalysisPaclitaxelPredictive Value of TestsPreoperative CareReceptor, ErbB-2ConceptsPathologic complete responseComplete responsePreoperative chemotherapyBreast cancerEstrogen receptor-negative subtypesPathologic CR rateEstrogen receptor statusBasal-like groupDifferent molecular subtypesFine-needle aspirationAffymetrix U133A microarraysPreoperative paclitaxelCyclophosphamide chemotherapyReceptor statusCR rateLuminal tumorsDifferent prognosisNuclear gradeMolecular subtypesNeedle aspirationChemotherapy sensitivityChemotherapyCancerMolecular classificationHuman tumors
2003
Molecular profiles of invasive mucinous and ductal carcinomas of the breast a molecular case study
Pusztai L, Sotiriou C, Buchholz TA, Meric F, Symmans WF, Esteva FJ, Sahin A, Liu ET, Hortobagi GN. Molecular profiles of invasive mucinous and ductal carcinomas of the breast a molecular case study. Cancer Genetics 2003, 141: 148-153. PMID: 12606133, DOI: 10.1016/s0165-4608(02)00737-9.Peer-Reviewed Original ResearchConceptsExpression profilingComprehensive genetic analysisExpression of enzymesCDNA microarrayGenetic analysisMolecular case studyExpression profilesInhibitory genesNovel pathwayTumor phenotypeMolecular profileTherapeutic targetPhenotypeTarget therapeuticsBilateral cancerHistologic subclassificationDuctal carcinomaDifferent histologyProfilingHuman backgroundInvasive tumorsMucin productionCellular infiltrationMucinous phenotypeMolecular classification