Pharmacogenomic analysis of HER2 amplified breast cancer treated with preoperative trastuzumab and paclitaxel, 5-fluorouracil, epirubicin, cyclophosphamide (T/FEC) chemotherapy
Esteva F, Anderson K, Lin F, Nahta R, Mejia J, Altundag K, Buzdar A, Hortobagyi G, Symmans W, Pusztai L. Pharmacogenomic analysis of HER2 amplified breast cancer treated with preoperative trastuzumab and paclitaxel, 5-fluorouracil, epirubicin, cyclophosphamide (T/FEC) chemotherapy. Journal Of Clinical Oncology 2006, 24: 545-545. DOI: 10.1200/jco.2006.24.18_suppl.545.Peer-Reviewed Original ResearchBreast cancerOverall pathologic complete response ratePathologic complete response rateTrastuzumab-resistant cell linesAbsence of trastuzumabOnly preoperative chemotherapyComplete response rateReceptor mRNA expressionFine-needle aspirationConcomitant trastuzumabFEC chemotherapyPreoperative trastuzumabQuantitative estrogenCyclophosphamide chemotherapyPreoperative chemotherapyNodal statusResidual diseaseTumor sizeClinical variablesNuclear gradeNeedle aspirationPharmacogenomic predictorsMolecular predictorsResponse rateTrastuzumab