High-dose chemotherapy: how resistant is breast cancer?
Pusztai L, Hortobagyi G. High-dose chemotherapy: how resistant is breast cancer? Drug Resistance Updates 1998, 1: 62-72. PMID: 17092798, DOI: 10.1016/s1368-7646(98)80216-1.Peer-Reviewed Original ResearchHigh-dose chemotherapyClinical drug resistanceBreast cancerDrug resistancePartial responseClinical patternResponse rateComplete response rateHigh-dose therapyInitial complete responseObjective response rateStandard-dose chemotherapyDifferent clinical patternsMajority of patientsPrimary drug resistanceStem cell supportHigh cure ratesDrug-resistant clonesInduction therapyInitial chemosensitivityPathologic resistanceStable diseaseCancer dieOverall survivalComplete response