2005
Pharmacogenomics and Clinical Biomarkers in Drug Discovery and Development
Ross JS, Symmans WF, Pusztai L, Hortobagyi GN. Pharmacogenomics and Clinical Biomarkers in Drug Discovery and Development. American Journal Of Clinical Pathology 2005, 124: s29-s41. PMID: 16468416, DOI: 10.1309/xyqafanapync6x59.Peer-Reviewed Original ResearchConceptsHuman genome sequenceGene expression profilesGenome sequenceEpigenetic eventsExpression profilesProteomics researchDrug discoveryRapid evolutionComputational biologyPharmaceutical industryMolecular diagnosticsDiscoveryFurther understandingBiosensorRNABiologyAnticancerSequenceClinical biomarkersAnti-inflammatory drugsDrug efficacyToxicityPrediction of responseDevelopmentContinuous technological advancements
2004
Pharmacogenomics
Ross JS, Schenkein DP, Kashala O, Linette GP, Stec J, Symmans WF, Pusztai L, Hortobagyi GN. Pharmacogenomics. Advances In Anatomic Pathology 2004, 11: 211-220. PMID: 15220824, DOI: 10.1097/01.pap.0000131825.77317.ee.Peer-Reviewed Original ResearchConceptsDisease pathway genesGene expression patternsWhole-genome technologiesHuman genomeTranscriptional profilingGenome technologyPathway genesMolecular basisGenomic microarraysSNP technologySolid Tumors (RECIST) classificationExpression patternsTarget discoveryProteomics researchDrug targetsGenetic variantsNon-genetic factorsAnti-cancer drugsComputational biologyVariety of diseasesField of pharmacogeneticsDrug metabolizing enzymesToxic responseLeukemia/lymphomaGroup of drugs