Functional germline variants as potential co-oncogenes
Agarwal D, Nowak C, Zhang NR, Pusztai L, Hatzis C. Functional germline variants as potential co-oncogenes. Npj Breast Cancer 2017, 3: 46. PMID: 29177190, PMCID: PMC5700137, DOI: 10.1038/s41523-017-0051-5.Peer-Reviewed Original ResearchRecent genome sequencing studiesFunction of proteinsDifferent oncogenic eventsGermline variantsGenome sequencing studiesSomatic mutationsDriver mutationsPhenotypic variationSpecific cancer subtypesLarge breast cancer cohortSomatic driver mutationsSequencing studiesFull malignant transformationFunctional germline variantsCancer biologyRecurrent driver mutationsOncogenic eventsSomatic eventsMutationsGermline aberrationsGermline polymorphismsFamilial cancerIndividual cancersMalignant transformationPolymorphism