2013
First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease
George M, Novelli E, Shigemura N, Simon M, Feingold B, Krishnamurti L, Morrell M, Gries C, Haider S, Johnson B, Crespo M, Bhama J, Bermudez C, Yousem S, Toyoda Y, Champion H, Pilewski J, Gladwin M. First Successful Lung Transplantation for Sickle Cell Disease with Severe Pulmonary Arterial Hypertension and Pulmonary Veno‐Occlusive Disease. Pulmonary Circulation 2013, 3: 952-958. PMID: 25006411, PMCID: PMC4070828, DOI: 10.1086/674749.Peer-Reviewed Original ResearchPulmonary veno-occlusive diseaseVeno-occlusive diseasePulmonary arterial hypertensionLung transplantationArterial hypertensionFirst successful lung transplantationSevere pulmonary arterial hypertensionBilateral lung transplantationPulmonary vascular complicationsSuccessful lung transplantSuccessful lung transplantationSickle cell diseaseFirst successful outcomeLung transplantVascular complicationsPathological dataMultidisciplinary planningCell diseaseTransplantationSuccessful outcomePatientsDiseaseHypertensionFirst caseComplications
2011
Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity
Machado R, Barst R, Yovetich N, Hassell K, Kato G, Gordeuk V, Gibbs J, Little J, Schraufnagel D, Krishnamurti L, Girgis R, Morris C, Rosenzweig E, Badesch D, Lanzkron S, Onyekwere O, Castro O, Sachdev V, Waclawiw M, Woolson R, Goldsmith J, Gladwin M. Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. Blood 2011, 118: 855-864. PMID: 21527519, PMCID: PMC3148167, DOI: 10.1182/blood-2010-09-306167.Peer-Reviewed Original ResearchConceptsTricuspid regurgitation velocitySickle cell diseaseLower exercise capacityExercise capacityCell diseaseN-terminal pro-brain natriuretic peptideElevated tricuspid regurgitation velocityPro-brain natriuretic peptideSerious adverse eventsPulmonary arterial hypertensionSildenafil trialArterial hypertensionAdverse eventsWalk distanceDoppler echocardiographySCD patientsHospitalization ratesNatriuretic peptidePatientsSildenafilPredominant causePainHospitalizationTreatment effectsDisease