The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe
Nouraie M, Lee J, Zhang Y, Kanias T, Zhao X, Xiong Z, Oriss T, Zeng Q, Kato G, Gibbs J, Hildesheim M, Sachdev V, Barst R, Machado R, Hassell K, Little J, Schraufnagel D, Krishnamurti L, Novelli E, Girgis R, Morris C, Rosenzweig E, Badesch D, Lanzkron S, Castro O, Goldsmith J, Gordeuk V, Gladwin M. The relationship between the severity of hemolysis, clinical manifestations and risk of death in 415 patients with sickle cell anemia in the US and Europe. Haematologica 2012, 98: 464-472. PMID: 22983573, PMCID: PMC3659937, DOI: 10.3324/haematol.2012.068965.Peer-Reviewed Original ResearchConceptsRisk of deathSickle cell diseaseSickle cell anemiaClinical outcomesHemolytic componentPulse pressureCell diseaseOxygen saturationCell anemiaDirect markerRed blood cell microparticlesCutaneous leg ulcerationTricuspid regurgitation velocityIndependent risk factorCell-free hemoglobin concentrationsPulmonary systolic pressureVentricular diastolic dimensionSerum lactate dehydrogenaseSystemic pulse pressureLowest oxygen saturationTwo-year followHemoglobin SS patientsTotal bilirubin concentrationCertain clinical complicationsHigh hemoglobin F