2022
Enrollment Lessons from a Biological Assignment Study of Marrow Transplantation versus Standard Care for Adolescents and Young Adults with Sickle Cell Disease: Considerations for Future Gene and Cellular Therapy Trials
Krishnamurti L, Neuberg D, Sullivan K, Smith S, Eapen M, Walters M. Enrollment Lessons from a Biological Assignment Study of Marrow Transplantation versus Standard Care for Adolescents and Young Adults with Sickle Cell Disease: Considerations for Future Gene and Cellular Therapy Trials. Transplantation And Cellular Therapy 2022, 29: 217-221. PMID: 36270432, PMCID: PMC10539686, DOI: 10.1016/j.jtct.2022.10.008.Peer-Reviewed Original ResearchConceptsBone marrow transplantationSickle cell diseaseMarrow transplantationNonmalignant diseasesCell diseaseAdult sickle cell diseaseMyeloablative bone marrow transplantationSingle-arm feasibility studyYoung adultsCellular therapy trialsMulticenter National InstituteRegimen-related toxicitySingle-arm studyFrequency of HLACoronavirus disease 2019 (COVID-19) pandemicAcademic medical centerDisease 2019 pandemicShort-term endpointsBMT centersBMT regimenCare armPain episodesPrimary endpointStandard careCurative therapy
2018
Association of genetic variation in COMT gene with pain related to sickle cell disease in patients from the walk-PHaSST study
Zhang Y, Belfer I, Nouraie M, Zeng Q, Goel R, Chu Y, Krasiy I, Krishnamurti L. Association of genetic variation in COMT gene with pain related to sickle cell disease in patients from the walk-PHaSST study. Journal Of Pain Research 2018, 11: 537-543. PMID: 29559808, PMCID: PMC5856032, DOI: 10.2147/jpr.s149958.Peer-Reviewed Original ResearchVaso-occlusive pain episodesSickle cell diseasePain perceptionSCD patientsCell diseaseAfrican American SCD patientsVariability of painEmergency room visitsHealth care utilizationSelf-reported painPain episodesAcute painCare utilizationRoom visitsSS patientsFunctional variantsPainPatientsPsychological covariatesDisease biologyCOMT geneDiseaseRisk SNPsWomenCorresponding haplotypes
2011
Association of Genetic Variation in the Catechol-O-Methyl Transferase Gene with Pain and Six Minute Walk Distance in Sickle Cell Anemia Patients From the Walk-PHaSST Study
Zhang Y, Zeng Q, Belfer I, Goel R, Porter M, Chu Y, Barst R, Hassell K, Machado R, Goldsmith J, Gladwin M, Krishnamurti L. Association of Genetic Variation in the Catechol-O-Methyl Transferase Gene with Pain and Six Minute Walk Distance in Sickle Cell Anemia Patients From the Walk-PHaSST Study. Blood 2011, 118: 1075. DOI: 10.1182/blood.v118.21.1075.1075.Peer-Reviewed Original ResearchSickle cell diseaseAcute pain crisisChronic painPain crisisPain phenotypesPain rateSCD painSevere painPain sensitivitySingle nucleotide polymorphismsAG genotype carriersChronic pain ratesSickle cell anemia patientsType of painAfrican American patientsGenetic factorsDescription of painLogistic regression analysisLower pain sensitivityCOMT genetic variantsChi-square testMultinomial logistic regression analysisCatechol-O-methyl transferase (COMT) genePain episodesMild pain