2014
PETIT and PETIT 2: Treatment with Eltrombopag in 171 Children with Chronic Immune Thrombocytopenia (ITP)
Bussel J, Grainger J, de Miguel P, Despotovic J, Locatelli F, Chotsampancharoen T, Donyush E, Navarro J, Pongtanakul B, Komvilaisak P, Sosothikul D, Blanchette V, Drelichman G, Krishnamurti L, Sirachainan N, Connor P, David M, Holzhauer S, Lebedev V, Lemons R, Pospisilova D, Ramenghi U, Boayue K, Matthews D, Marcello L, Iyengar M, Chan G, Chagin K, Theodore D, Bakshi K, Bailey C. PETIT and PETIT 2: Treatment with Eltrombopag in 171 Children with Chronic Immune Thrombocytopenia (ITP). Blood 2014, 124: 1450. DOI: 10.1182/blood.v124.21.1450.1450.Peer-Reviewed Original ResearchChronic immune thrombocytopeniaImmune thrombocytopeniaThrombopoietin receptor agonistsAdverse eventsPlatelet count responsePlatelet countStudy treatmentITP medicationsSerious AEsPBO groupRandomized periodX ULNReceptor agonistRandomized phaseTreatment groupsMedian average daily doseOral thrombopoietin receptor agonistUpper respiratory tract infectionMost subjectsAdvisory CommitteeDose of eltrombopagEfficacy of eltrombopagPediatric immune thrombocytopeniaPre-existing cataractCommon adverse events
2010
Platelet Transfusions In Patients with Immune Thrombocytopenic Purpura (ITP) – Evaluation of the Current Nationwide Inpatient Hospital Practices.
Tran L, Goel R, Krishnamurti L. Platelet Transfusions In Patients with Immune Thrombocytopenic Purpura (ITP) – Evaluation of the Current Nationwide Inpatient Hospital Practices. Blood 2010, 116: 3809. DOI: 10.1182/blood.v116.21.3809.3809.Peer-Reviewed Original ResearchImmune thrombocytopenic purpuraManagement of ITPMajor bleedsPlatelet transfusionsHospital dischargeMortality rateGastrointestinal bleedITP patientsIntracranial hemorrhageNationwide Inpatient Sample 2007Payer inpatient databasePlatelet transfusion practicesInternational consensus guidelinesImproved mortality ratesStratified probability sampleU.S. community hospitalsThrombocytopenic purpuraPlatelet countTransfusion practiceConsensus guidelinesInpatient DatabaseMean ageSevere hemorrhageCommunity hospitalPediatric discharges